{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:56:14Z","timestamp":1774497374075,"version":"3.50.1"},"reference-count":52,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100009024","name":"Exploratory Research for Advanced Technology","doi-asserted-by":"crossref","award":["JPMJER2102"],"award-info":[{"award-number":["JPMJER2102"]}],"id":[{"id":"10.13039\/501100009024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Japan Society for Promotion of Science (JSPS) KAKENHI Grant-in Aid for Scientific Research","award":["24 K10773"],"award-info":[{"award-number":["24 K10773"]}]},{"name":"the Japan Society of Medical Physics"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2025,1,19]]},"abstract":"Abstract<\/jats:title>\n \n Objective.<\/jats:italic> The tumor microenvironment characterized by heterogeneously organized vasculatures causes intra-tumoral heterogeneity of oxygen partial pressure \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> at the cellular level, which cannot be measured by current imaging techniques. The intra-tumoral cellular \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> heterogeneity may lead to a reduction of therapeutic effects of radiation. The purpose of this study was to investigate the effects of the heterogeneity on biological effectiveness of H-, He-, C-, O-, and Ne-ion beams for different oxygenation levels, prescribed dose levels, and cell types. Approach.<\/jats:italic> The intra-tumoral cellular \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> distributions were simulated with a numerical tumor model for average oxygen pressures \n \n \n \n \n \n \n \n p<\/mml:mi>\n \u00af<\/mml:mo>\n <\/mml:mover>\n <\/mml:mrow>\n \n t<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> ranging from 2.5 to 15 mmHg. The relative biological effectiveness (RBE)-weighted dose distributions of 3\u201315 Gy prescribed doses were planned for a cuboid target with the five ion species for constant \n \n \n \n \n \n \n \n p<\/mml:mi>\n \u00af<\/mml:mo>\n <\/mml:mover>\n <\/mml:mrow>\n \n t<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> values. Radiosensitivities of human salivary gland tumor (HSG) and Chinese hamster ovary (CHO) cells were investigated. The planned dose distributions were then recalculated by taking the \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> heterogeneity into account. Main results.<\/jats:italic> As \n \n \n \n \n \n \n \n p<\/mml:mi>\n \u00af<\/mml:mo>\n <\/mml:mover>\n <\/mml:mrow>\n \n t<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> decreased and prescribed dose increased, the biological effectiveness of the ion beams decreased due to the \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> heterogeneity. The reduction in biological effectiveness was pronounced for lighter H- and He-ion beams compared to heavier C-, O-, and Ne-ion beams. The RBE-weighted dose in the target for HSG (CHO) cells decreased by 41.2% (44.3%) for the H-ion beam, while it decreased by 16.7% (14.7%) for the Ne-ion beam at a prescribed dose of 15 Gy under a \n \n \n \n \n \n \n \n p<\/mml:mi>\n \u00af<\/mml:mo>\n <\/mml:mover>\n <\/mml:mrow>\n \n t<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> of 2.5 mmHg. Significance.<\/jats:italic> The intra-tumoral cellular \n \n \n \n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula> heterogeneity causes a significant reduction in biological effectiveness of ion beams. These effects should be considered in estimation of therapeutic outcomes.<\/jats:p>","DOI":"10.1088\/1361-6560\/ada5a5","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T22:55:27Z","timestamp":1735944927000},"page":"025008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams"],"prefix":"10.1088","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-4004","authenticated-orcid":true,"given":"Taku","family":"Inaniwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-764X","authenticated-orcid":true,"given":"Takamitsu","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-9933","authenticated-orcid":true,"given":"Nobuyuki","family":"Kanematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"pmbada5a5bib1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/jrr\/rrs070","article-title":"Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions","volume":"54","author":"Antonovic","year":"2013","journal-title":"J. Radiat. Res."},{"key":"pmbada5a5bib2","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1093\/jrr\/rru020","article-title":"Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes","volume":"55","author":"Antonovic","year":"2014","journal-title":"J. Radiat. Res."},{"key":"pmbada5a5bib3","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3109\/0284186X.2010.510640","article-title":"Dose- and LET-painting with particle therapy","volume":"49","author":"Bassler","year":"2010","journal-title":"Acta Oncol."},{"key":"pmbada5a5bib4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/0284186X.2013.832835","article-title":"LET-painting increases tumor control probability in hypoxic tumor","volume":"53","author":"Bassler","year":"2014","journal-title":"Acta Oncol."},{"key":"pmbada5a5bib5","doi-asserted-by":"publisher","first-page":"i77","DOI":"10.1093\/jrr\/rrt050","article-title":"A Monte Carlo-based treatment-planning tool for ion beam therapy","volume":"54","author":"B\u00f6hlen","year":"2013","journal-title":"J. Radiat. Res."},{"key":"pmbada5a5bib6","doi-asserted-by":"publisher","first-page":"7983","DOI":"10.1088\/0031-9155\/57\/23\/7983","article-title":"Investigating the robustness of ion beam therapy treatment plans to uncertainties in biological treatment parameters","volume":"57","author":"B\u00f6hlen","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib7","doi-asserted-by":"publisher","first-page":"7586","DOI":"10.1088\/0031-9155\/61\/21\/7586","article-title":"Adaptation of the microdosimetric kinetic model to hypoxia","volume":"61","author":"Bopp","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0360-3016(95)00544-9","article-title":"A convenient expression of the linear-quadratic model to include redistribution and reoxygenation","volume":"32","author":"Brenner","year":"1995","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbada5a5bib9","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.ijrobp.2010.10.007","article-title":"Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia","volume":"79","author":"Carlson","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbada5a5bib10","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1118\/1.2229427","article-title":"A effects of oxygen on intrinsic radiation sensitivity: a test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters","volume":"33","author":"Carlson","year":"2006","journal-title":"Med. Phys."},{"key":"pmbada5a5bib11","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1088\/0031-9155\/48\/17\/307","article-title":"Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia","volume":"48","author":"Dasu","year":"2003","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib12","doi-asserted-by":"publisher","DOI":"10.1118\/1.4812431","article-title":"A model to simulate the oxygen distribution in hypoxic tumors for different vascular architectures","volume":"40","author":"Espinoza","year":"2013","journal-title":"Med. Phys."},{"key":"pmbada5a5bib13","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1667\/0033-7587(2000)154[0485:IOAAHC]2.0.CO;2","article-title":"Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated He-, C- and Ne-ion beams","volume":"154","author":"Furusawa","year":"2000","journal-title":"Radiat. Res."},{"key":"pmbada5a5bib14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1667\/RRXX41.1","article-title":"Corrections: in the article \u201cinactivation of aerobic and hypoxic cells from three different cell lines by accelerated He-, C- and Ne-ion beams\u201d","volume":"177","author":"Furusawa","year":"2012","journal-title":"Radiat. Res."},{"key":"pmbada5a5bib15","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/abde99","article-title":"Application of lung substitute material as ripple filter for multi-ion therapy with helium-, carbon-, oxygen-, and neon-ion beams","volume":"66","author":"Inaniwa","year":"2021a","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib16","doi-asserted-by":"publisher","first-page":"N542","DOI":"10.1088\/0031-9155\/61\/20\/N542","article-title":"Effective particle energies for stopping power calculation in radiotherapy treatment planning with protons and helium, carbon, and oxygen ions","volume":"61","author":"Inaniwa","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib17","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aabede","article-title":"Adaptation of stochastic microdosimetric kinetic model for charged-particle therapy treatment planning","volume":"63","author":"Inaniwa","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib18","doi-asserted-by":"publisher","first-page":"64685","DOI":"10.1093\/jrr\/rrad049","article-title":"Event-by-event approach to the oxygen-effect-incorporated stochastic microdosimetric kinetic model for hypofractionated multi-ion therapy","volume":"64","author":"Inaniwa","year":"2023","journal-title":"J. Radiat. Res."},{"key":"pmbada5a5bib19","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ad4085","article-title":"Biological dose optimization incorporating intra-tumoral cellular radiosensitivity heterogeneity in ion-beam therapy treatment planning","volume":"69","author":"Inaniwa","year":"2024a","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib20","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ad3dbb","article-title":"Modeling of the resensitization effect on carbon-ion radiotherapy for stage I non-small cell lung cancer","volume":"69","author":"Inaniwa","year":"2024b","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib21","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1088\/1361-6560\/aa68d7","article-title":"Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization","volume":"62","author":"Inaniwa","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib22","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ac29cc","article-title":"Adaptation of stochastic microdosimetric kinetic model to hypoxia for hypo-fractionated multi-ion therapy treatment planning","volume":"66","author":"Inaniwa","year":"2021b","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib23","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab5fee","article-title":"Nuclear interaction correction for patient dose calculations in treatment planning of helium-, carbon-, oxygen-, and neon-ion beams","volume":"65","author":"Inaniwa","year":"2020a","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib24","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab6eba","article-title":"Experimental validation of stochastic microdosimetric kinetic model for multi-ion therapy treatment planning with helium-, carbon-, oxygen-, and neon-ion beams","volume":"65","author":"Inaniwa","year":"2020b","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib25","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12194-023-00721-6","article-title":"Stopping-power ratio of body tissues with updated effective energies and elemental I values for treatment planning of proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions","volume":"16","author":"Inaniwa","year":"2023","journal-title":"Radiol. Phys. Technol."},{"key":"pmbada5a5bib26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0360-3016(98)00544-6","article-title":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiotherapy","volume":"44","author":"Kanai","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"pmbada5a5bib27","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110180","article-title":"Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers","volume":"194","author":"Koto","year":"2024","journal-title":"Radiother. Oncol."},{"key":"pmbada5a5bib28","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1140\/epjd\/e2014-40843-x","article-title":"Overview of recent advances in treatment planning for ion beam radiotherapy","volume":"68","author":"Kr\u00e4mer","year":"2014","journal-title":"Eur. Phys. J. D"},{"key":"pmbada5a5bib29","doi-asserted-by":"publisher","first-page":"5017","DOI":"10.1088\/0031-9155\/57\/15\/5017","article-title":"First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg ion-beam therapy center","volume":"57","author":"Kurz","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib30","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/abd66f","article-title":"Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters","volume":"66","author":"Lee","year":"2021","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/1748-717X-9-149","article-title":"Treatment fractionation for stereotactic radiotherapy of lung tumours: a modeling study of the influence of chronic and acute hypoxia on tumour control probability","volume":"9","author":"Lindblom","year":"2014a","journal-title":"Radiat. Oncol."},{"key":"pmbada5a5bib32","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3109\/0284186X.2014.925582","article-title":"Survival and tumor control probability in tumours with heterogeneous oxygenation: a comparison between the linear-quadratic and the universal survival curve models for high doses","volume":"53","author":"Lindblom","year":"2014b","journal-title":"Acta Oncol."},{"key":"pmbada5a5bib33","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.1088\/0031-9155\/51\/19\/012","article-title":"Adapting radiotherapy to hypoxic tumors","volume":"51","author":"Malinen","year":"2006","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib34","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ad1f87","article-title":"Effects of cellular radioresponse on therapeutic helium-, carbon-, oxygen-, and neon-ion beams: a simulation study","volume":"69","author":"Masuda","year":"2024","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib35","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20130676","article-title":"Defining normoxia, physoxia and hypoxia in tumors\u2014implications for treatment response","volume":"87","author":"McKeown","year":"2014","journal-title":"Br. J. Radiol."},{"key":"pmbada5a5bib36","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1088\/0031-9155\/57\/6\/1675","article-title":"Modeling and simulation of the influence of acute and chronic hypoxia on 18F fluoromisonidazole PET imaging","volume":"57","author":"M\u00f6nnich","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.radonc.2012.09.015","article-title":"FAZA PET\/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial","volume":"105","author":"Mortensen","year":"2012","journal-title":"Radiat. Oncol."},{"key":"pmbada5a5bib38","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1158\/1078-0432.CCR-05-1907","article-title":"Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia","volume":"12","author":"Nakano","year":"2006","journal-title":"Clin. Cancer. Res."},{"key":"pmbada5a5bib39","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1158\/1078-0432.CCR-16-1209","article-title":"Noninvasive imaging of cycling hypoxia in head and neck cancer using intrinsic susceptibility MRI","volume":"23","author":"Panek","year":"2017","journal-title":"Clin. Cancer. Res."},{"key":"pmbada5a5bib40","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ac8968","article-title":"Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter","volume":"67","author":"Sakata","year":"2022","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib41","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1088\/0031-9155\/58\/11\/3871","article-title":"Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification","volume":"58","author":"Scifoni","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib42","doi-asserted-by":"publisher","first-page":"7798","DOI":"10.1088\/1361-6560\/aa88a0","article-title":"Oxygen beams for therapy: advanced biological treatment planning and experimental verification","volume":"62","author":"Sokol","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib43","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aafe40","article-title":"Kill painting of hypoxic tumors with multiple ion beams","volume":"64","author":"Sokol","year":"2019","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib44","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aa89ae","article-title":"Tumor control in ion beam radiotherapy with different ions in the presence of hypoxia: an oxygen enhancement ratio model based on the microdosimetric kinetic model","volume":"63","author":"Strigari","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib45","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ad5d49","article-title":"Method for fabricating a mesh ripple filter for charged-particle therapy","volume":"69","author":"Tanaka","year":"2024","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib46","doi-asserted-by":"publisher","first-page":"13NT01","DOI":"10.1088\/1361-6560\/ac762d","article-title":"Development of ripple filter composed of metal mesh for charged-particle therapy","volume":"67","author":"Tanaka","year":"2022","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib47","doi-asserted-by":"publisher","DOI":"10.1038\/srep17016","article-title":"Kill-painting of hypoxic tumors in charged particle therapy","volume":"5","author":"Tinganelli","year":"2015","journal-title":"Sci. Rep."},{"key":"pmbada5a5bib48","doi-asserted-by":"publisher","first-page":"i23","DOI":"10.1093\/jrr\/rrt065","article-title":"Influence of acute hypoxia and radiation quality on cell survival","volume":"54","author":"Tinganelli","year":"2013","journal-title":"J. Radiat. Res."},{"key":"pmbada5a5bib49","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1088\/0031-9155\/53\/17\/001","article-title":"An imaging-based tumour growth and treatment response model: investigating the effect of tumour oxygenation on radiation therapy response","volume":"53","author":"Titz","year":"2008","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib50","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.1088\/0031-9155\/49\/19\/002","article-title":"The relationship between temporal variation of hypoxia, polarographic measurements and predictions of tumor response to radiation","volume":"49","author":"Toma-Dasu","year":"2004","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib51","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1088\/0031-9155\/56\/11\/006","article-title":"Modeling of the oxygen enhancement ratio for ion beam radiation therapy","volume":"56","author":"Wenzl","year":"2011a","journal-title":"Phys. Med. Biol."},{"key":"pmbada5a5bib52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/1748-717X-6-171","article-title":"Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical application","volume":"6","author":"Wenzl","year":"2011b","journal-title":"Radiat. Oncol."}],"container-title":["Physics in Medicine & Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:32:23Z","timestamp":1737023543000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ada5a5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,16]]},"published-print":{"date-parts":[[2025,1,19]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ada5a5","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"Effects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-10-03","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-01-03","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-01-16","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}