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Collagen deposition is directly included in the computational model, while composite material theory is used to convert fat content to the microscopic mechanical properties, which in turn is included in the computational model. The results illustrate the model\u2019s ability to capture the effect of both fat and collagen deposition on the viscoelastic moduli and represents a step towards linking histopathological changes in the liver to its bulk mechanical properties, which can eventually provide insights for accurate diagnosis with elastography.<\/jats:p>","DOI":"10.1088\/1361-6560\/adaad3","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T22:59:26Z","timestamp":1736981966000},"page":"045005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Towards linking histological changes to liver viscoelasticity: a hybrid analytical-computational micromechanics approach"],"prefix":"10.1088","volume":"70","author":[{"given":"Haritya","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-3435","authenticated-orcid":true,"given":"Murthy N","family":"Guddati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"pmbadaad3bib1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/hep4.1446","article-title":"Multiparametric magnetic resonance elastography improves the detection of NASH regression following bariatric surgery","volume":"4","author":"Allen","year":"2020a","journal-title":"Hepatol. 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