{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:40:02Z","timestamp":1745480402589,"version":"3.40.4"},"reference-count":17,"publisher":"IOP Publishing","issue":"9","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Yorkshire Cancer Research","award":["L389AA"],"award-info":[{"award-number":["L389AA"]}]},{"name":"Region Nordjyllands Sundhedsvidenskabelige Forskningsfond 2020"},{"name":"DCCC Radiotherapy - The Danish National Research Center for Radiotherapy"},{"DOI":"10.13039\/501100010344","name":"Aage og Johanne Louis-Hansens Fond","doi-asserted-by":"crossref","award":["19-2B-5625"],"award-info":[{"award-number":["19-2B-5625"]}],"id":[{"id":"10.13039\/501100010344","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Direkt\u00f8r Jens Aage S\u00f8rensen og Hustru Edith Ingeborg S\u00f8rensens Mindefond"},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["C19942\/A28832"],"award-info":[{"award-number":["C19942\/A28832"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"name":"T\u00f8mrermester J\u00f8rgen Holm og hustru Elisa f. Hansens Mindefond","award":["20006-1979"],"award-info":[{"award-number":["20006-1979"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2025,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective.<\/jats:italic> To quantify interfraction shape and positional variations of primary tumor volumes for rectal cancer patients receiving long course radiotherapy by comparing two quantification strategies: a center-of-mass (COM) method and a surface-based metric that captures local deformations. <jats:italic>Approach.<\/jats:italic> This study utilized repeat MRI scans before and during radiotherapy (RT) for rectal cancer to investigate the positional variation of the primary gross tumor volume (GTVp). Sixteen patients underwent six MRI exams, with the initial three before the RT course and the subsequent three at one, two, and four weeks into the RT course. GTVp\u2019s were delineated on 3D T2-weighted MRIs, and positional variation analyzed using both COM and point-based surface displacements against the initial scan. Surface displacements were quantified using a bidirectional local distance measure, analyzing 3D displacement vectors. Additionally, the study examined local right\u2013left (RL) and anterior\u2013posterior (AP) surface variations relative to tumor height in the rectum by mapping baseline GTVp volumes onto a reference rectum structure. <jats:italic>Main results.<\/jats:italic> Systematic error for COM measurements were 1.7, 1.3 and 2.0 mm for AP, RL, and cranial\u2013caudal (CC) direction, respectively. Random errors were 2.1, 1.2 and 2.2 mm, while the GM errors were \u22120.3, 0.5 and \u22120.3 mm for AP, RL, and CC directions, respectively. An increase in systematic and random errors were observed when comparing 95th percentile surface displacements to the COM measurements, indicating local displacements which the COM did not detect. Additionally, a general tendency for higher-located tumors to experience larger left\u2013right and AP surface variations were seen when evaluating the 95th percentile. <jats:italic>Significance.<\/jats:italic> COM-based analysis might underestimate local deformations. Consequently, surface-based methods might provide more robust estimations of systematic, random and group mean errors for planning target volume-margin calculation. The surface variations tend to increase for tumors located in the upper part of the rectum.<\/jats:p>","DOI":"10.1088\/1361-6560\/adcaf8","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T22:52:01Z","timestamp":1744239121000},"page":"095004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating primary tumor position variation for rectal cancer patients treated with long course radiotherapy"],"prefix":"10.1088","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7980-5539","authenticated-orcid":true,"given":"Dennis Tideman","family":"Arp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-9218","authenticated-orcid":true,"given":"Ane L","family":"Appelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasa","family":"Mikalone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3955-7266","authenticated-orcid":true,"given":"Martin Skovmos","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-976X","authenticated-orcid":true,"given":"Laurids \u00d8stergaard","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"pmbadcaf8bib1","doi-asserted-by":"publisher","first-page":"S76","DOI":"10.1016\/S0167-8140(21)00186-9","article-title":"PH-0162: is there a radiation dose-response relationship for non-operative management of rectal cancer?","volume":"152","author":"Appelt","year":"2020","journal-title":"Radiother. 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