{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:58:37Z","timestamp":1773388717229,"version":"3.50.1"},"reference-count":25,"publisher":"IOP Publishing","issue":"19","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018985","name":"Waalse Gewest","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018985","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective<\/jats:italic>. The FLASH effect, characterized by potential sparing of organs at risk (OARs) through ultra-high dose rate (DR) irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional DRs with hypofractionated schemes. While considerable biological research is needed to understand the FLASH effect and determine the FLASH modifying factors (FMF) for individual OARs, treatment planning studies have also emerged. This study evaluates the feasibility of achieving FLASH conditions in proton stereotactic body radiotherapy for spine metastases and establishes the required FMFs under different fractionation regimens. <jats:italic>Approach<\/jats:italic>. A conformal FLASH Proton SBRT plan was generated for a patient with spine metastasis in a research version of RayStation11B (RaySearch laboratories AB, Stockholm) on an IBA Proteus Plus system. Two oblique posterior beams were used in the plan. The prescribed dose to the CTV was set according to 3 different fractionation regimens: 5 fractions (fx) of 7\u2009Gy, 8\u2009fx of 5\u2009Gy, and 10\u2009fx of 4.2\u2009Gy. Spot filtering and sorting techniques were applied to maximize the 5% pencil beam scanning DR in the spinal cord (SC). The FLASH effect was assumed to be observed within irradiated regions above 40\u2009Gy\u2009s<jats:sup>\u22121<\/jats:sup> and 4\u2009Gy per fraction. <jats:italic>Main results<\/jats:italic>. The generated plans successfully ensure robust target coverage in each fraction. The volume of SC that does not comply with the clinical goal adheres to the FLASH effect conditions in each fraction. Depending on the aforementioned fractionation schemes used, a FMF of approximately 0.6 to 0.8 is necessary to enable such treatment in FLASH conditions. <jats:italic>Significance<\/jats:italic>. This study indicates that treating challenging spine metastases with protons using FLASH delivery is technically feasible. However, clinical viability depends on optimistic parameters to trigger the FLASH effect and FMF values below 0.8, which are not yet guaranteed given current research.<\/jats:p>","DOI":"10.1088\/1361-6560\/ae023c","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:48:17Z","timestamp":1756856897000},"page":"19NT01","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["FLASH-enabled proton SBRT for a challenging case of spine metastasis"],"prefix":"10.1088","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-7213","authenticated-orcid":false,"given":"Sophie","family":"Wuyckens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena Chocan","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6693-2443","authenticated-orcid":true,"given":"Viktor","family":"Wase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7997-3865","authenticated-orcid":true,"given":"Dario","family":"Di Perri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Geets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-546X","authenticated-orcid":true,"given":"Edmond","family":"Sterpin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"pmbae023cbib1","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.ijrobp.2022.05.038","type":"journal-article","article-title":"Normal tissue sparing by FLASH as a function of single-fraction dose: a quantitative analysis","volume":"114","author":"B\u00f6hlen","year":"2022","journal-title":"Int. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-09-10","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-09-01","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-09-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}