{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:43:06Z","timestamp":1788172986593,"version":"build-2803163510"},"reference-count":53,"publisher":"IOP Publishing","issue":"15","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"National Cancer Institute","award":["R01CA298804"],"award-info":[{"award-number":["R01CA298804"]}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R21NS125089"],"award-info":[{"award-number":["R21NS125089"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","award":["R01EB03122"],"award-info":[{"award-number":["R01EB03122"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Many applications of magnetic nanoparticles (MNPs) require accumulation at target organs that can be challenging to achieve and to characterize. Magnetic particle imaging (MPI) enables sensitive and quantitative detection of MNPs, however the proximity of target signals to high accumulation organs hinders accurate quantification due to signal spillover effects. Specifically, we sought to systematically evaluate MPI quantification strategies under conditions mimicking pre-clinical animal studies and account for spillover.\n                    <jats:italic>Approach.<\/jats:italic>\n                    We developed an anatomically accurate 3D-printed mouse phantom with a fillable liver cavity, brain and lung ports and a hind flank cavity. By emulating high liver MNP uptake alongside low MNP concentrations in target locations at varying distances, we compared quantification from threshold-based and constant-volume segmentations, as well as a subtraction approach, both for 2D and 3D MPI scans.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Thresholding was reliable for isolated high-signal regions but overestimated signal near the liver or at low signal-to-noise ratios. Constant-volume segmentation improved signal separation, and subtraction strategies mitigated spillover overestimation, enhancing the limit of quantification. With the subtraction approach we were able to quantify as low a signal as 0.05 and 0.25% of the total dose in the phantom in the brain\/lung and hind flank of the mouse phantom with 3D MPI, respectively.\n                    <jats:italic>Significance.<\/jats:italic>\n                    These results underscore the importance of accounting for superimposed signals in quantitative MPI and highlight anatomically correct phantoms as essential tools for refining biodistribution assessment methods in nanomedicine using MPI.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ae91c7","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:55:43Z","timestamp":1785279343000},"page":"155024","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Systematic evaluation of magnetic particle imaging quantification strategies in biologically relevant scenarios using anatomically correct 3D printed mouse phantoms"],"prefix":"10.1088","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-1856","authenticated-orcid":true,"given":"Daniela P","family":"Vald\u00e9s","sequence":"first","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5084-7587","authenticated-orcid":true,"given":"Sarah N","family":"Zammataro","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Melnyk","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambar C","family":"Velazquez-Albino","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sk","family":"Rajab Ali","sequence":"additional","affiliation":[{"name":"University of Florida"},{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8886-5612","authenticated-orcid":true,"given":"Carlos M","family":"Rinaldi-Ramos","sequence":"additional","affiliation":[{"name":"University of Florida"},{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"pmbae91c7bib1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.2967\/jnumed.108.060442","type":"journal-article","article-title":"Identification of a shine-through artifact in the trachea with 124I PET\/CT","volume":"50","author":"Abdul-Fatah","year":"2009","journal-title":"J. Nucl. Med."},{"key":"pmbae91c7bib2","doi-asserted-by":"publisher","first-page":"4042","DOI":"10.1021\/nl902212q","type":"journal-article","article-title":"Ultrastable iron oxide nanoparticle colloidal suspensions using dispersants with catechol-derived anchor groups","volume":"9","author":"Amstad","year":"2009","journal-title":"Nano Lett."},{"key":"pmbae91c7bib3","article-title":"Standard test method for iron in trace quantities using the 1, 10-phenanthroline method","author":"ASTM Committee E15 on Industrial and Speciality","year":"2004","type":"other"},{"key":"pmbae91c7bib4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1177\/02611929241241187","type":"journal-article","article-title":"It\u2019s time to review the three Rs, to make them more fit for purpose in the 21st century","volume":"52","author":"Bailey","year":"2024","journal-title":"Altern. Lab. Anim."},{"key":"pmbae91c7bib5","article-title":"3D Slicer image computing platform","author":"BWH and 3D Slicer contributors","type":"other"},{"key":"pmbae91c7bib6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.23736\/S1824-4785.17.02969-7","type":"journal-article","article-title":"Radiolabeled inorganic nanoparticles for positron emission tomography imaging of cancer: an overview","volume":"61","author":"Chakravarty","year":"2017","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"pmbae91c7bib7","doi-asserted-by":"publisher","first-page":"19810","DOI":"10.1021\/acsnano.3c04037","type":"journal-article","article-title":"Meta-analysis of nanoparticle distribution in tumors and major organs in tumor-bearing mice","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"pmbae91c7bib8","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1021\/acsnano.9b08142","type":"journal-article","article-title":"Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach","volume":"14","author":"Cheng","year":"2020","journal-title":"ACS Nano"},{"key":"pmbae91c7bib9","doi-asserted-by":"publisher","first-page":"164-209","DOI":"10.1007\/s13167-010-0001-x","type":"journal-article","article-title":"Drug delivery systems: advanced technologies potentially applicable in personalized treatments","volume":"1","author":"Coelho","year":"2010","journal-title":"EPMA J."},{"key":"pmbae91c7bib10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00259-020-04984-8","type":"journal-article","article-title":"Sentinel lymph node detection in oral cancer: a within-patient comparison between [Tc]Tc-tilmanocept and [Tc]Tc-nanocolloid","volume":"48","author":"den Toom","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"pmbae91c7bib11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1088\/0031-9155\/52\/3\/003","type":"journal-article","article-title":"Digimouse: a 3D whole body mouse atlas from CT and cryosection data","volume":"52","author":"Dogdas","year":"2007","journal-title":"Phys. Med. Biol."},{"key":"pmbae91c7bib12","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.ejrad.2013.11.023","type":"journal-article","article-title":"Hepatic hemangiomas: factors associated with T2 shine-through effect on diffusion-weighted MR sequences","volume":"83","author":"Duran","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"pmbae91c7bib13","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.2147\/ijn.s76501","type":"journal-article","article-title":"Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents","volume":"10","author":"Estelrich","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"pmbae91c7bib14","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.18416\/IJMPI.2024.2411001","type":"journal-article","article-title":"Focused small field of view magnetic particle imaging for the isolation and quantification of MPI signal in tumours","volume":"10","author":"Fernando","year":"2024","journal-title":"Int. J. Magn. Part. Imaging"},{"key":"pmbae91c7bib15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s41747-023-00359-4","type":"journal-article","article-title":"In vivo tracking of adenoviral-transduced iron oxide-labeled bone marrow-derived dendritic cells using magnetic particle imaging","volume":"7","author":"Fink","year":"2023","journal-title":"Eur. Radiol. Exp."},{"key":"pmbae91c7bib16","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1002\/jmri.25044","type":"journal-article","article-title":"Apparent diffusion coefficient-dependent voxelwise computed diffusion-weighted imaging: an approach for improving SNR and reducing T 2 shine-through effects: Contrast optimization in dwi","volume":"43","author":"Gatidis","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"pmbae91c7bib17","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409117","type":"journal-article","article-title":"Responsive magnetic particle imaging tracer: overcoming \u201calways-on\u201d limitation, eliminating interference and ensuring safety in adaptive therapy","volume":"36","author":"Guan","year":"2024","journal-title":"Adv. Mater."},{"key":"pmbae91c7bib18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s11307-020-01533-5","type":"journal-article","article-title":"Artificial intelligence analysis of magnetic particle imaging for islet transplantation in a mouse model","volume":"23","author":"Hayat","year":"2020","journal-title":"Mol. Imaging Biol."},{"key":"pmbae91c7bib19","doi-asserted-by":"publisher","first-page":"83170R","DOI":"10.1117\/12.916097","type":"conference-proceedings","article-title":"In vivo imaging and quantification of iron oxide nanoparticle uptake and biodistribution","volume":"8317","author":"Hoopes","year":"2012"},{"key":"pmbae91c7bib20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/978-1-4614-7657-319","type":"book","article-title":"3D Slicer: A Platform for Subject-Specific Image Analysis, Visualization and Clinical Support","author":"Kikinis","year":"2013"},{"key":"pmbae91c7bib21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-3-642-04199-02","type":"book","article-title":"How Magnetic Particle Imaging Works","author":"Knopp","year":"2012"},{"key":"pmbae91c7bib22","doi-asserted-by":"publisher","first-page":"951","DOI":"10.2967\/jnumed.114.147637","type":"journal-article","article-title":"Shine-through in PET\/MR imaging: effects of the magnetic field on positron range and subsequent image artifacts","volume":"56","author":"Kolb","year":"2015","journal-title":"J. Nucl. Med."},{"key":"pmbae91c7bib23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10334-017-0637-9","type":"journal-article","article-title":"Assessment of MRI contrast agent concentration by quantitative susceptibility mapping (QSM): application to estimation of cerebral blood volume during steady state","volume":"30","author":"Lind","year":"2017","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"pmbae91c7bib24","doi-asserted-by":"publisher","first-page":"348","DOI":"10.7150\/ntno.58548","type":"journal-article","article-title":"Long circulating tracer tailored for magnetic particle imaging","volume":"5","author":"Liu","year":"2021","journal-title":"Nanotheranostics"},{"key":"pmbae91c7bib25","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1007\/s11095-012-0818-1","type":"journal-article","article-title":"Biodistribution studies of nanoparticles using fluorescence imaging: a qualitative or quantitative method?","volume":"29","author":"Liu","year":"2012","journal-title":"Pharm. Res."},{"key":"pmbae91c7bib26","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1109\/TMI.2013.2257177","type":"journal-article","article-title":"Linearity and shift invariance for quantitative magnetic particle imaging","volume":"32","author":"Lu","year":"2013","journal-title":"IEEE Trans. Med. Imaging"},{"key":"pmbae91c7bib27","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116989","type":"journal-article","article-title":"Nanobiotechnology-based strategies in alleviation of chemotherapy-mediated cardiotoxicity","volume":"238","author":"Luo","year":"2023","journal-title":"Environ. Res."},{"key":"pmbae91c7bib28","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114517002227","type":"journal-article","article-title":"The 3Rs in research: a contemporary approach to replacement, reduction and refinement","volume":"120","author":"MacArthur Clark","year":"2017","journal-title":"Br. J. Nutr."},{"key":"pmbae91c7bib29","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-8825005\/v1","type":"preprint","article-title":"Magnetic particle imaging in human subjects","author":"Mason","year":"2026"},{"key":"pmbae91c7bib30","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1021\/acsnano.8b02881","type":"journal-article","article-title":"Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited","volume":"12","author":"Meng","year":"2018","journal-title":"ACS Nano"},{"key":"pmbae91c7bib31","doi-asserted-by":"publisher","first-page":"8515","DOI":"10.1016\/S0040-4020(01)86599-6","type":"journal-article","article-title":"A new oxidation pathway of the neurotoxin 6-aminodopamine. Isolation and characterisation of a dimer with a tetrahydro[3, 4a]iminoethanophenoxazine ring system","volume":"48","author":"Napolitano","year":"1992","journal-title":"Tetrahedron"},{"key":"pmbae91c7bib32","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114238","type":"journal-article","article-title":"Why nanoparticles prefer liver macrophage cell uptake in vivo","volume":"185","author":"Ngo","year":"2022","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"pmbae91c7bib33","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s11547-015-0519-z","type":"journal-article","article-title":"T2 shine-through phenomena in diffusion-weighted MR imaging of lumbar discs after oxygen\u2013ozone discolysis: a randomized, double-blind trial with steroid and O2\u2013O3 discolysis versus steroid only","volume":"120","author":"Perri","year":"2015","journal-title":"Radiol. Med."},{"key":"pmbae91c7bib34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jmmm.2016.11.008","type":"journal-article","article-title":"Design and characterization of a device to quantify the magnetic drug targeting efficiency of magnetic nanoparticles in a tube flow phantom by magnetic particle spectroscopy","volume":"427","author":"Radon","year":"2017","journal-title":"J. Magn. Magn. Mater."},{"key":"pmbae91c7bib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18416\/IJMPI.2025.2503045","type":"journal-article","article-title":"A study of flow dynamics in a realistic aneurysm phantom using MPI, MRI and OT","volume":"11","author":"Reichl","year":"2025","journal-title":"Int. J. Magn. Part. Imaging"},{"key":"pmbae91c7bib36","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2025.1664209","type":"journal-article","article-title":"Revisiting 3Rs: rethinking replacement and new approach methodologies","volume":"7","author":"Rosolowski","year":"2025","journal-title":"Front. Toxicol."},{"key":"pmbae91c7bib37","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1109\/TMI.2025.3530316","type":"journal-article","article-title":"A physics-based computational forward model for efficient image reconstruction in magnetic particle imaging","volume":"44","author":"Sanders","year":"2025","journal-title":"IEEE Trans. Med. Imaging"},{"key":"pmbae91c7bib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmro.2023.100138","type":"journal-article","article-title":"MR based magnetic susceptibility measurements of 3D printing materials at 3 Tesla","volume":"16-17","author":"Sangal","year":"2023","journal-title":"J. Magn. Reson. Open"},{"key":"pmbae91c7bib39","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10299","type":"journal-article","article-title":"An anatomically correct 3D-printed mouse phantom for magnetic particle imaging studies","volume":"7","author":"Sarna","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"pmbae91c7bib40","doi-asserted-by":"publisher","first-page":"umae024","DOI":"10.1093\/radadv\/umae024","type":"journal-article","article-title":"Magnetic particle imaging enables nonradioactive quantitative sentinel lymph node identification: feasibility proof in murine models","volume":"1","author":"Sehl","year":"2024","journal-title":"Radiol. Adv."},{"key":"pmbae91c7bib41","doi-asserted-by":"publisher","DOI":"10.18416\/IJMPI.2022.2208002","type":"conference-proceedings","article-title":"MPI region of interest (ROI) analysis and quantification of iron in different volumes","volume":"8","author":"Sehl","year":"2022"},{"key":"pmbae91c7bib42","doi-asserted-by":"publisher","first-page":"tfae044","DOI":"10.1093\/toxres\/tfae044","type":"journal-article","article-title":"New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption","volume":"13","author":"Sewell","year":"2024","journal-title":"Toxicol. Res."},{"key":"pmbae91c7bib43","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s44303-025-00084-0","type":"journal-article","article-title":"Spillover can limit accurate signal quantification in MPI","volume":"3","author":"Shakeri-Zadeh","year":"2025","journal-title":"npj Imaging"},{"key":"pmbae91c7bib44","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114326","type":"journal-article","article-title":"Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: possibilities and challenges","volume":"186","author":"Skotland","year":"2022","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"pmbae91c7bib45","doi-asserted-by":"publisher","first-page":"13913","DOI":"10.1021\/acsnano.0c06326","type":"journal-article","article-title":"Monitoring intracranial cerebral hemorrhage using multicontrast real-time magnetic particle imaging","volume":"14","author":"Szwargulski","year":"2020","journal-title":"ACS Nano"},{"key":"pmbae91c7bib46","doi-asserted-by":"publisher","DOI":"10.5061\/dryad.59zw3r2pz","type":"dataset","article-title":"Systematic evaluation of magnetic particle imaging quantification strategies in biologically relevant scenarios using anatomically correct 3D printed mouse phantoms","author":"Vald\u00e9s","year":"2026","unstructured":"Vald\u00e9s D P Zammataro S N Melnyk A Velazquez-Albino A C Ali S R Rinaldi-Ramos C M 2026 Systematic evaluation of magnetic particle imaging quantification strategies in biologically relevant scenarios using anatomically correct 3D printed mouse phantoms Dryad 10.5061\/dryad.59zw3r2pz"},{"key":"pmbae91c7bib47","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1039\/D5NR03157E","type":"journal-article","article-title":"Esterification synthesis of iron oxide nanoparticle tracers for magnetic particle imaging (MPI)","volume":"18","author":"Velazquez-Albino","year":"2026","journal-title":"Nanoscale"},{"key":"pmbae91c7bib48","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2603.12010","type":"preprint","article-title":"First in-vivo human magnetic particle imaging","author":"Vogel","year":"2026"},{"key":"pmbae91c7bib49","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.procir.2023.03.154","type":"journal-article","article-title":"Classification of phantoms for medical imaging","volume":"119","author":"Wegner","year":"2023","journal-title":"Proc. CIRP"},{"key":"pmbae91c7bib50","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14","type":"journal-article","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"pmbae91c7bib51","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3390\/bioengineering11101034","type":"journal-article","article-title":"Advances in medical image segmentation: a comprehensive review of traditional, deep learning and hybrid approaches","volume":"11","author":"Xu","year":"2024","journal-title":"Bioengineering"},{"key":"pmbae91c7bib52","doi-asserted-by":"publisher","first-page":"12067","DOI":"10.1021\/acsnano.7b04844","type":"journal-article","article-title":"Magnetic particle imaging for highly sensitive, quantitative and safe in vivo gut bleed detection in a murine model","volume":"11","author":"Yu","year":"2017","journal-title":"ACS Nano"},{"key":"pmbae91c7bib53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2025.173365","type":"journal-article","article-title":"On the effect of reference and sample volume on magnetic particle imaging quantification","volume":"630","author":"Zammataro","year":"2025","journal-title":"J. Magn. Magn. Mater."}],"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:45:03Z","timestamp":1786103103000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/ae91c7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":53,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8,7]]},"published-print":{"date-parts":[[2026,8,14]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/ae91c7","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"Systematic evaluation of magnetic particle imaging quantification strategies in biologically relevant scenarios using anatomically correct 3D printed mouse phantoms","name":"article_title","label":"Article Title"},{"value":"Physics in Medicine & Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2026-03-28","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-07","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}