{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:23:44Z","timestamp":1787210624152,"version":"build-2736575974"},"reference-count":26,"publisher":"IOP Publishing","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["12405380"],"award-info":[{"award-number":["12405380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Traditional radiotherapy dosimetric analyses are often limited by cone-beam CT artifacts and correlated longitudinal data mismanagement. This study uses artifact-free fan-beam CT (FBCT) and a generalized linear mixed Lasso (glmmLasso) model to decouple interfraction setup errors and anatomical deformations within a simulated image-guided radiotherapy workflow, providing quantitative support for future site-specific ART research.\n                    <jats:italic>Approach.<\/jats:italic>\n                    We retrospectively analyzed 84 patients (head and neck [H&amp;N], thorax, pelvis; n = 28 each). Weekly diagnostic-quality FBCTs served as ground truth. To isolate error sources, we recalculated 1 260 dose distributions under three scenarios: isolated setup errors, isolated deformations, and combined effects. A glmmLasso model, using patient-specific random intercepts and\n                    <jats:bold>\n                      <jats:italic>L1<\/jats:italic>\n                    <\/jats:bold>\n                    penalization, identified the primary geometric drivers of dosimetric variation.\n                    <jats:italic>Main Results.<\/jats:italic>\n                    H&amp;N exhibited minimal setup deviations (&lt; 2.0 mm); dosimetric variance was driven by inter-patient baseline heterogeneity (ICC &gt; 0.73) rather than interfraction deformations. Thoracic setup uncertainties (mean\u22484.0 mm) reduced minimum target dose up to 50% for displacements \u2a7e 5 mm, but overall variance was primarily governed by non-rigid deformations (marginal\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.423). Pelvic anatomy demonstrated pronounced variability due to bladder filling (DSC: 0.2\u20130.9), and the coupled scenario further amplified relative deviations in bladder and femoral-head dose metrics.\n                    <jats:italic>Significance.<\/jats:italic>\n                    Utilizing FBCT and high-dimensional feature selection, we decoupled site-specific drivers of dosimetric variation. Quantifying these coupled effects establishes a robust, validated foundation for tailored potential factors to inform ART decision-making.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ae95aa","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:54:51Z","timestamp":1785970491000},"page":"165014","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoupling the dosimetric impact of setup errors and anatomical deformations in image-guided radiotherapy using diagnostic-quality FBCT and glmmLasso regularization"],"prefix":"10.1088","volume":"71","author":[{"given":"Lianzi","family":"Zhao","sequence":"first","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5887-3694","authenticated-orcid":true,"given":"Yuanshuai","family":"Di","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Yang","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louzheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadi","family":"Gao","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Hu","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-1479","authenticated-orcid":true,"given":"Yang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center"},{"name":"Fudan University"},{"name":"Shanghai Clinical Research Center for Radiation Oncology"},{"name":"Shanghai Key Laboratory of Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"pmbae95aabib1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.25122\/jml-2022-0241","type":"journal-article","article-title":"Assessing setup errors and shifting margins for planning target volume in head, neck, and breast","volume":"16","author":"Alabedi","year":"2023","journal-title":"Cancer J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-05-25","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-20","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}