{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:33:27Z","timestamp":1787045607301,"version":"build-2736575974"},"reference-count":35,"publisher":"IOP Publishing","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"National Science Foundation CAREER","award":["1943937"],"award-info":[{"award-number":["1943937"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Although commercial and native extracellular matrices (ECM) are studied as ultrasound-responsive materials, the influence of their viscoelastic properties on ultrasound responses remains unclear. This study examines how focused ultrasound (FUS) peak negative pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u2212) and pulse length affect acoustic cavitation probability and dynamics in commercial and native ECM (nECM).\n                    <jats:italic>Approach<\/jats:italic>\n                    . A 3.68 MHz single element FUS transducer (f# = 1) delivered 100\u2013600\n                    <jats:italic>\u03bc<\/jats:italic>\n                    s pulses at 1 Hz with\n                    <jats:italic>p<\/jats:italic>\n                    \u2212\u2a7d 6.2 MPa in commercial ECM scaffolds (PureCol EZ-Gel and Cultrex Ultimatrix) as well as nECM derived from decellularized porcine kidney and liver. A 3.68 MHz FUS transducer (f# = 1) delivered 100\u2013600\n                    <jats:italic>\u03bc<\/jats:italic>\n                    s pulses at 1 Hz PRF with\n                    <jats:italic>p<\/jats:italic>\n                    \u2212\u2a7d 6.2 MPa. Cavitation events were captured using brightfield microscopy and high-speed imaging at 20 000 fps. A viscoelasticity corrected Rayleigh\u2013Plesset based bubble model was compared with the experimental results.\n                    <jats:italic>Main Results<\/jats:italic>\n                    . The nECM derived from decellularized porcine kidney and liver, having higher elastic moduli compared to PureCol and Cultrex, consistently exhibited higher cavitation thresholds. Increasing the pulse length from 200 to 600\n                    <jats:italic>\u03bc<\/jats:italic>\n                    s reduced cavitation thresholds in liver (5.6\u20134.2 MPa,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003) and kidney (5.5\u20134.1 MPa,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.005) nECM, whereas in commercial scaffolds EZ-Gel and Cultrex, thresholds showed minimal change beyond 300\n                    <jats:italic>\u03bc<\/jats:italic>\n                    s. Experimentally, the largest bubble radii were observed in PureCol EZ-Gel (14.8 \u00b1 3.6\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m) and the smallest were observed in Cultrex (6.8 \u00b1 1.3\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m). The computational model qualitatively matched the experimental results for the smallest observed radius and indicated that viscosity was the primary factor in damping bubble expansion compared to elastic modulus. As Cultrex had the highest viscosity of all tested materials, it also showed the minimum radial expansion of\n                    <jats:italic>r<\/jats:italic>\n                    = 5.4\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m.\n                    <jats:italic>Significance<\/jats:italic>\n                    . Results suggest that medium elasticity influences cavitation threshold and maximum bubble expansion is predominantly affected by both elasticity and viscosity of the medium, which may help interpret cavitation behavior across different ECM conditions.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ae95d5","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:57:49Z","timestamp":1785970669000},"page":"165006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of acoustic cavitation from focused ultrasound in commercial and native extracellular matrices"],"prefix":"10.1088","volume":"71","author":[{"given":"Ferdousi Sabera","family":"Rawnaque","sequence":"first","affiliation":[{"name":"The Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-9939","authenticated-orcid":true,"given":"Julianna C","family":"Simon","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"pmbae95d5bib1","article-title":"Viscosity of PureCol\u00ae, Nutragen\u00ae, and FibriCol\u00ae collagen","author":"Advanced BioMatrix","year":"2016","type":"web-resource"},{"key":"pmbae95d5bib2","article-title":"Hydrogel stiffness of diluted PureCol","author":"Advanced BioMatrix","year":"2019","type":"web-resource"},{"key":"pmbae95d5bib3","article-title":"PureCol\u00ae","author":"Advanced BioMatrix","year":"2026","type":"web-resource"},{"key":"pmbae95d5bib4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/boc.201600078","type":"journal-article","article-title":"Are cancer cells really softer than normal cells?","volume":"109","author":"Alibert","year":"2017","journal-title":"Biol. 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