{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:19:53Z","timestamp":1787660393273,"version":"build-2736575974"},"reference-count":19,"publisher":"IOP Publishing","issue":"16","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The history of optimization in radiation oncology is closely intertwined with the history of\n                    <jats:italic>Physics in Medicine &amp; Biology<\/jats:italic>\n                    (\n                    <jats:italic>PMB<\/jats:italic>\n                    ). Over the past four decades, many of the conceptual advances that transformed radiotherapy\u2014from forward planning to inverse planning, from physical to biological optimization, and from treatment planning to treatment strategy optimization\u2014were first reported in the pages of this journal. Looking back from the perspective of PMB\u2019s seventieth anniversary, one can trace a remarkably consistent intellectual trajectory: the progressive expansion of optimization from the design of radiation dose distributions to the optimization of entire cancer treatment pathways.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/ae9a29","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:52:59Z","timestamp":1786747979000},"page":"162001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From optimization of radiation dose distributions to optimal cancer treatments"],"prefix":"10.1088","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-0398","authenticated-orcid":true,"given":"Thomas","family":"Bortfeld","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Webb","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research and Royal Marsden NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"pmbae9a29bib1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aab4b6","type":"journal-article","article-title":"Adaptive treatment-length optimization in spatiobiologically integrated radiotherapy","volume":"63","author":"Ajdari","year":"2018","journal-title":"Phys. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-06-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-14","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}