{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:21:44Z","timestamp":1790565704280,"version":"4.1.0"},"reference-count":26,"publisher":"IOP Publishing","issue":"17","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00347270"],"award-info":[{"award-number":["RS-2024-00347270"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Spatial harmonic imaging (SHI) enables single-shot multi-contrast x-ray imaging, including dark-field imaging (DFI) and differential phase-contrast imaging (DPCI). However, spectral overlap between the first-harmonic band and adjacent spectra can produce wraparound artifacts and structural distortions. Asymmetric spectral filtering (ASF) has recently been proposed to suppress such artifacts in SHI-based DFI, but its effect on the first-harmonic signal and its applicability to DPCI remain unclear. This study aimed to analyze the effect of ASF on the first-harmonic signal and systematically investigate its applicability to DPCI, with particular emphasis on the delineation of small calcification-like inclusions in a breast-equivalent phantom and soft-tissue boundaries and internal structures in a biological specimen.\n                    <jats:italic>Approach.<\/jats:italic>\n                    The effect of ASF on the first-harmonic signal was analyzed using a first-order approximation. Monte Carlo simulations and x-ray imaging experiments were conducted using symmetric filtering, low-frequency-only filtering, and ASF for comparison.\n                    <jats:italic>Main results.<\/jats:italic>\n                    In simulations of a breast-equivalent phantom containing small hydroxyapatite inclusions, ASF increased the edge-based signal-to-noise ratio (ESNR) by a factor of 1.96 compared with symmetric filtering. In fish specimen experiments, ASF achieved a 2.46-fold improvement in ESNR and enabled clearer delineation of boundaries and internal structures. In the experiment involving a banana specimen with an inserted pencil lead, ASF yielded the highest ESNR and clearest target delineation.\n                    <jats:italic>Significance.<\/jats:italic>\n                    These results suggest that ASF reduces spectral-overlap artifacts while allowing phase-related information relevant to DPCI to remain reflected in the reconstructed phase. The resulting improvements in the delineation of small calcification-like inclusions in a breast-equivalent phantom and soft-tissue boundaries and internal structures in a biological specimen support the biomedical relevance of ASF for single-shot SHI-based DPCI under the investigated low-energy and small-specimen conditions.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/aea04c","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:54:17Z","timestamp":1787957657000},"page":"175027","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Asymmetric spectral filtering for spectral-overlap suppression and differential phase-contrast reconstruction in spatial harmonic imaging"],"prefix":"10.1088","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-2598","authenticated-orcid":true,"given":"Hyunwoo","family":"Lim","sequence":"first","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1655-7329","authenticated-orcid":true,"given":"Jonghyeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6685-8884","authenticated-orcid":false,"given":"Seohee","family":"Han","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-6312","authenticated-orcid":true,"given":"Hyosung","family":"Cho","sequence":"additional","affiliation":[{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"pmbaea04cbib1","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1118\/1.3501311","type":"journal-article","article-title":"A grating\u2010based single\u2010shot x\u2010ray phase contrast and diffraction method for in vivo imaging","volume":"37","author":"Bennett","year":"2010","journal-title":"Med. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-05-22","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-08","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}