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Med. Biol."],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Magnetic resonance imaging (MRI) is increasingly required to operate near electronic devices that emit dynamic electromagnetic interference (EMI). Existing reference-channel EMI removal methods estimate a transfer function between EMI sensors and imaging coils from the measured data alone, and do not use prior knowledge about the structure of MR images. We develop and validate an EMI removal method that uses the inherent spatial smoothness of MR images as an additional prior, demonstrated on a head-only 0.5 T scanner.\n                    <jats:italic>Approach.<\/jats:italic>\n                    Smooth total variation regularization for interference detection and elimination (STRIDE) operates in the image domain. For each image column, EMI sensor data are combined and subtracted from the imaging coil data such that the\n                    <jats:inline-formula>\n                      <jats:tex-math>\n                        \n                      <\/jats:tex-math>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                        <mml:mrow>\n                          <mml:mi>L<\/mml:mi>\n                        <\/mml:mrow>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    2 norm of the total variation (TV) along the readout direction is minimized. This exploits the smoothness of MR images, a property well-known in compressed sensing but not previously used in EMI removal. STRIDE was evaluated on phantom and\n                    <jats:italic>in-vivo<\/jats:italic>\n                    brain datasets under EMI scenarios replicating sources encountered at our affiliated hospitals, and compared against two implementations of External Dynamic Interference Estimation and Removal (EDITER).\n                    <jats:italic>Main results.<\/jats:italic>\n                    STRIDE produced visually better EMI removal and generally higher temporal signal-to-noise ratio than both EDITER implementations, with comparable EMI removal percentage. STRIDE also resulted in lower or equal root-mean-square error than both EDITER implementations in all 8 phantom EMI conditions tested. These results held across both phantom and\n                    <jats:italic>in-vivo<\/jats:italic>\n                    datasets.\n                    <jats:italic>Significance.<\/jats:italic>\n                    STRIDE shows that incorporating known properties of MR images into the EMI removal problem provides meaningful improvements over methods that rely on measured data alone. The approach is deterministic, training-free, sequence-independent, and compatible with existing EMI sensor hardware. STRIDE therefore extends reference-channel EMI removal to scenarios where existing methods fail, particularly point-of-care and interventional MRI outside fully shielded environments, providing a deterministic, training-free alternative to machine-learning approaches.\n                  <\/jats:p>","DOI":"10.1088\/1361-6560\/aeb29e","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:52:22Z","timestamp":1791586342000},"page":"205023","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Smooth total variation regularization for interference detection and elimination (STRIDE) for MRI"],"prefix":"10.1088","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-0444","authenticated-orcid":true,"given":"Alexander","family":"Mertens","sequence":"first","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4272-7782","authenticated-orcid":false,"given":"Diego","family":"Martinez","sequence":"additional","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5595-5381","authenticated-orcid":false,"given":"Amgad","family":"Louka","sequence":"additional","affiliation":[{"name":"University Health Network"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8804-566X","authenticated-orcid":true,"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2004-468X","authenticated-orcid":false,"given":"Chad","family":"Harris","sequence":"additional","affiliation":[{"name":"Synaptive Medical"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-3603","authenticated-orcid":true,"given":"Ian","family":"Connell","sequence":"additional","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"},{"name":"University Health Network"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"pmbaeb29ebib1","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1002\/mrm.30374","type":"journal-article","article-title":"Design and operation of a whole-body MRI scanner without RF shielding","volume":"93","author":"Biber","year":"2025","journal-title":"Magn. 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