{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:29Z","timestamp":1792798769743,"version":"4.5.0"},"reference-count":0,"publisher":"IOP Publishing","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CGRS"],"award-info":[{"award-number":["CGRS"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CRC-2019-00039"],"award-info":[{"award-number":["CRC-2019-00039"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-03516"],"award-info":[{"award-number":["RGPIN-2021-03516"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["USRA"],"award-info":[{"award-number":["USRA"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Nature et technologies","doi-asserted-by":"publisher","award":["Master's"],"award-info":[{"award-number":["Master's"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Nature et technologies","doi-asserted-by":"publisher","award":["USRA supplement"],"award-info":[{"award-number":["USRA supplement"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phys. Med. Biol."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: To evaluate the feasibility of delivering minibeam radiotherapy (MBRT) to a canine glioblastoma patient using a novel low-cost dual-robot kilovoltage (kV) x-ray system.  &amp;#xD;  &amp;#xD;Approach: A workflow to perform MBRT using a tungsten collimator with 300 \u03bcm slits was developed for the 225 kVp x-ray source system. A Monte Carlo (MC) model of MBRT was built in TOPAS and validated with EBT4 measurements in-air and in a solid water phantom. A non-coplanar MBRT treatment plan with 2 mm Al- and 0.5 mm Cu-filtered beams was created for the canine patient and compared to a clinical 6 MV VMAT plan. A full set and individual minibeam fields were delivered to a canine head phantom with an intracranial film to verify plan feasibility.&amp;#xD;&amp;#xD;Main results: Measured and MC-simulated peak-to-valley dose ratios in-air and in the water phantom agreed within \u2264 2\u03c3. Open-beam and collimated peak dose measurements at depths acquired with films in the water phantom agreed with simulations with mean relative differences of 1% and 2%, respectively. MBRT treatment plan spatial fractionation was preserved in healthy tissue for tissue-sparing benefits.  Mean MBRT doses to organs at risk were within 15% of VMAT, except for skin (+52% for Al- and +48% for Cu-filtered beams), bone (+28% for Al and +22% for Cu) and the right ear (-39% for Al and -42% for Cu). Dose difference map average in the canine head phantom was 2.3 \u00b1 1.2% for one and 3.5 \u00b1 2.2% for two minibeam fields. &amp;#xD;&amp;#xD;Significance: These results demonstrate the feasibility of MBRT delivery using the novel x-ray system to a canine due to spatial fractionation and adequate depth dose delivered to the tumor.<\/jats:p>","DOI":"10.1088\/1361-6560\/aeb8dd","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:54:07Z","timestamp":1792796047000},"source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of canine minibeam radiotherapy (MBRT) with a dual-robot kilovoltage x-ray system"],"prefix":"10.1088","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0672-6315","authenticated-orcid":false,"given":"Laura","family":"Dufort-Gagnon","sequence":"first","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8862-1263","authenticated-orcid":false,"given":"Jade","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1139-0521","authenticated-orcid":false,"given":"Josh","family":"Chapman","sequence":"additional","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Stewart","sequence":"additional","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4241-9262","authenticated-orcid":false,"given":"Olivia","family":"Masella","sequence":"additional","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0340-3080","authenticated-orcid":false,"given":"Nicola","family":"Carbone","sequence":"additional","affiliation":[{"name":"Dunlee, brand of Philips"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-2889","authenticated-orcid":false,"given":"Magdalena","family":"Bazalova-Carter","sequence":"additional","affiliation":[{"name":"University of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,23]]},"container-title":["Physics in Medicine &amp; Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aeb8dd","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aeb8dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aeb8dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aeb8dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:54:08Z","timestamp":1792796048000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aeb8dd"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1088\/1361-6560\/aeb8dd","relation":{},"ISSN":["0031-9155","1361-6560"],"issn-type":[{"value":"0031-9155","type":"print"},{"value":"1361-6560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]}}}