{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:02:10Z","timestamp":1784984530590,"version":"3.55.0"},"reference-count":8,"publisher":"IOP Publishing","issue":"7","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"crossref","award":["JSM is an NIHR Academic Clinical Fellow"],"award-info":[{"award-number":["JSM is an NIHR Academic Clinical Fellow"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . PaCO\n                    <jats:sub>2<\/jats:sub>\n                    affects cerebral blood flow (CBF) and its regulatory mechanisms, but the effects of CO\n                    <jats:sub>2<\/jats:sub>\n                    measurement technique on cerebrovascular parameters are unknown. In order to determine if the two most commonly used approaches, face mask (FM) or nasal cannulae (NC), are interchangeable or not, we tested the hypothesis that the use of FM versus NC does not lead to significant differences in CO\n                    <jats:sub>2<\/jats:sub>\n                    -related systemic and cerebrovascular parameters.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Recordings of CBF velocity (CBFV), blood pressure (BP), heart rate, and end-tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    (EtCO\n                    <jats:sub>2<\/jats:sub>\n                    ) were performed in 42 subjects during normocapnia (FM or NC) and 5% CO\n                    <jats:sub>2<\/jats:sub>\n                    inhalation (FM) or hyperventilation (NC). Dynamic cerebral autoregulation was assessed with the autoregulation index (ARI), derived by transfer function analysis from the CBFV response to a hypothetical step change in BP.\n                    <jats:italic>Main Results<\/jats:italic>\n                    . Significant differences in physiological parameters were seen between FM and NC: EtCO\n                    <jats:sub>2<\/jats:sub>\n                    (37.40 versus 35.26 mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.001) and heart rate (69.6 versus 66.7 bpm,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.001) respectively. No differences were observed for mean BP, CBFV or the ARI index.\n                    <jats:italic>Significance<\/jats:italic>\n                    . Use of FM or NC for measurement of EtCO\n                    <jats:sub>2<\/jats:sub>\n                    leads to physiological changes and differences in parameter values that need to be taken into consideration when interpreting and\/or comparing results in studies of cerebral haemodynamics.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aa6f9f","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T11:45:20Z","timestamp":1493207120000},"page":"N101-N106","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["PaCO\n                    <sub>2<\/sub>\n                    measurement in cerebral haemodynamics: face mask or nasal cannulae?"],"prefix":"10.1088","volume":"38","author":[{"given":"J S","family":"Minhas","sequence":"first","affiliation":[{"name":"University of Leicester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Robinson","sequence":"additional","affiliation":[{"name":"University of Leicester"},{"name":"Glenfield Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Panerai","sequence":"additional","affiliation":[{"name":"University of Leicester"},{"name":"Glenfield Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"pmeaaa6f9fbib001","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.brainres.2008.07.048","type":"journal-article","article-title":"Dynamic cerebral autoregulation and baroreflex sensitivity during modest and severe step changes in arterial PCO2","volume":"1230","author":"Ainslie","year":"2008","journal-title":"Brain Res."},{"key":"pmeaaa6f9fbib002","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1113\/jphysiol.2011.206052","type":"journal-article","article-title":"The cerebrovascular response to carbon dioxide in humans","volume":"589","author":"Battisti-Charbonney","year":"2011","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-02-08","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-04-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-06-22","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}