{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:23:00Z","timestamp":1792639380190,"version":"4.5.0"},"reference-count":69,"publisher":"IOP Publishing","issue":"12","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective:<\/jats:italic>\n                    As precision medicine is becoming a standard of care in selecting tailored rather than average treatments, physiological measurements might represent the first step in applying personalized therapy in the intensive care unit (ICU). A systematic assessment of respiratory mechanics in patients with the acute respiratory distress syndrome (ARDS) could represent a step in this direction, for two main reasons.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Approach and Main results:<\/jats:italic>\n                    On the one hand, respiratory mechanics are a powerful physiological method to understand the severity of this syndrome in each single patient. Decreased respiratory system compliance, for example, is associated with low end expiratory lung volume and more severe lung injury.\n                  <\/jats:p>\n                  <jats:p>On the other hand, respiratory mechanics might guide protective mechanical ventilation settings. Improved gravitationally dependent regional lung compliance could support the selection of positive end-expiratory pressure and maximize alveolar recruitment. Moreover, the association between driving airway pressure and mortality in ARDS patients potentially underlines the importance of sizing tidal volume on respiratory system compliance rather than on predicted body weight.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Significance:<\/jats:italic>\n                    The present review article aims to describe the main alterations of respiratory mechanics in ARDS as a potent bedside tool to understand severity and guide mechanical ventilation settings, thus representing a readily available clinical resource for ICU physicians.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aa9052","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T11:15:13Z","timestamp":1506942913000},"page":"R280-H303","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Respiratory mechanics to understand ARDS and guide mechanical ventilation"],"prefix":"10.1088","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-8162","authenticated-orcid":false,"given":"Tommaso","family":"Mauri","sequence":"first","affiliation":[{"name":"University of Milan"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"},{"name":"University of Ferrara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bellani","sequence":"additional","affiliation":[{"name":"University of Milan-Bicocca"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zanella","sequence":"additional","affiliation":[{"name":"University of Milan"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Grasselli","sequence":"additional","affiliation":[{"name":"University of Milan"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"pmeaaa9052bib001","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1164\/ajrccm.152.6.8520744","type":"journal-article","article-title":"Beneficial effects of the \u2018open lung approach\u2019 with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation","volume":"152","author":"Amato","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib002","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1056\/NEJMsa1410639","type":"journal-article","article-title":"Driving pressure and survival in the acute respiratory distress syndrome","volume":"372","author":"Amato","year":"2015","journal-title":"New Eng. J. Med."},{"key":"pmeaaa9052bib003","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1088\/0967-3334\/26\/1\/002","type":"journal-article","article-title":"Effects of viscoelasticity on volume distribution in a two-compartmental model of normal and sick lungs","volume":"26","author":"Antonaglia","year":"2005","journal-title":"Physiol. Meas."},{"key":"pmeaaa9052bib004","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","type":"journal-article","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"ARDSnet","year":"2000","journal-title":"New Engl. J. Med."},{"key":"pmeaaa9052bib005","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(67)90168-7","type":"journal-article","article-title":"Acute respiratory distress in adults","volume":"2","author":"Ashbaugh","year":"1967","journal-title":"Lancet"},{"key":"pmeaaa9052bib006","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1088\/1361-6579\/aa6923","type":"journal-article","article-title":"Global and regional assessment of sustained inflation pressure-volume curves in patients with acute respiratory distress syndrome","volume":"38","author":"Becher","year":"2017","journal-title":"Physiol. Meas."},{"key":"pmeaaa9052bib007","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1164\/rccm.201008-1318OC","type":"journal-article","article-title":"Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury","volume":"183","author":"Bellani","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib008","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/MCC.0b013e32834eb47d","type":"journal-article","article-title":"Imaging in acute lung injury and acute respiratory distress syndrome","volume":"18","author":"Bellani","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"pmeaaa9052bib009","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","type":"journal-article","article-title":"Epidemiology, patterns of care and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"23","author":"LUNG SAFE Investigators ESICM Trials Group","year":"2016a","journal-title":"JAMA"},{"key":"pmeaaa9052bib010","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13054-016-1290-9","type":"journal-article","article-title":"Do spontaneous and mechanical breathing have similar effects on average transpulmonary and alveolar pressures? A clinical crossover study","volume":"20","author":"Bellani","year":"2016b","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib011","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/BF00263528","type":"journal-article","article-title":"Respiratory compliance and resistance in mechanically ventilated patients with acute respiratory failure","volume":"4","author":"Bernasconi","year":"1988","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib012","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00134-013-2898-8","type":"journal-article","article-title":"Ventilation distribution measured with EIT at varying levels of pressure support and neurally adjusted ventilatory assist in patients with ALI","volume":"39","author":"Blankman","year":"2013","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib013","first-page":"913","type":"journal-article","article-title":"Endotoxin and lung injury","volume":"133","author":"Brigham","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"pmeaaa9052bib014","doi-asserted-by":"publisher","first-page":"R150","DOI":"10.1186\/cc7139","type":"journal-article","article-title":"Nitrogen washout\/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume","volume":"12","author":"Chiumello","year":"2008","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib015","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13054-016-1446-7","type":"journal-article","article-title":"Airway driving pressure and lung stress in ARDS patients","volume":"20","author":"Chiumello","year":"2016","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib016","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/10\/3\/036008","type":"journal-article","article-title":"Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome","volume":"10","author":"Christley","year":"2013","journal-title":"Phys. Biol."},{"key":"pmeaaa9052bib017","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/CCM.0000000000001036","type":"journal-article","article-title":"Impact of chest wall modifications and lung injury on the correspondence between airway and transpulmonary driving pressure","volume":"43","author":"Cortes-Puentes","year":"2015","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib018","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/cc13979","type":"journal-article","article-title":"Electrical impedance tomography: so close to touching the holy grail","volume":"18","author":"Constantin","year":"2014","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib019","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1164\/rccm.201308-1567OC","type":"journal-article","article-title":"Lung inhomogeneity in patients with acute respiratory distress syndrome","volume":"189","author":"Cressoni","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib020","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1063\/1.349386","type":"journal-article","article-title":"Analysis of behavior of the respiratory system in ARDS patients: effects of flow, volume, and time","volume":"70","author":"Eissa","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"pmeaaa9052bib021","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1152\/jappl.1982.53.4.967","type":"journal-article","article-title":"Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance","volume":"53","author":"Esbensahde","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"pmeaaa9052bib022","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1164\/ajrccm.156.4.96-02031","type":"journal-article","article-title":"End-inspiratory airway occlusion: a method to assess the pressure developed by inspiratory muscles in patients with acute lung injury undergoing pressure support","volume":"156","author":"Foti","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib023","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1164\/rccm.201605-1055OC","type":"journal-article","article-title":"Bedside contribution of electrical impedance tomography to set positive end-expiratory pressure for ECMO-treated severe ARDS patients","volume":"196","author":"Franchineau","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib024","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/thoraxjnl-2016-208357","type":"journal-article","article-title":"Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group","volume":"72","author":"Frerichs","year":"2017","journal-title":"Thorax"},{"key":"pmeaaa9052bib025","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/00000542-200601000-00026","type":"journal-article","article-title":"Gravity, the belly, and the diaphragm: you can\u2019t ignore physics","volume":"104","author":"Froese","year":"2006","journal-title":"Anesthesiology"},{"key":"pmeaaa9052bib026","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00265800","type":"journal-article","article-title":"The role of total static lung compliance in the management of severe ARDS unresponsive to conventional treatment","volume":"10","author":"Gattinoni","year":"1984","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib027","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1164\/ajrccm\/136.3.730","type":"journal-article","article-title":"Pressure\u2013volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study","volume":"136","author":"Gattinoni","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"pmeaaa9052bib028","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1007\/s00134-005-2627-z","type":"journal-article","article-title":"The concept of \u2018baby lung\u2019","volume":"31","author":"Gattinoni","year":"2005","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib030","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00134-015-4200-8","type":"journal-article","article-title":"The \u2018baby lung\u2019 became an adult","volume":"42","author":"Gattinoni","year":"2016","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib031","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00134-012-2490-7","type":"journal-article","article-title":"ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure","volume":"38","author":"Grasso","year":"2012","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib032","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/s13054-016-1556-2","type":"journal-article","article-title":"Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials","volume":"20","author":"Guerin","year":"2016","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib033","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1097\/CCM.0b013e31828a3de5","type":"journal-article","article-title":"Pleural pressure and optimal positive end-expiratory pressure based on esophageal pressure versus chest wall elastance: incompatible results","volume":"41","author":"Gulati","year":"2013","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib034","first-page":"11","type":"journal-article","article-title":"Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation","volume":"17","author":"Hodgson","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"pmeaaa9052bib035","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1164\/rccm.200712-1822OC","type":"journal-article","article-title":"Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury","volume":"178","author":"Hong","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib036","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1097\/ALN.0b013e3182518bc0","type":"journal-article","article-title":"Ventilator-induced lung injury is mediated by the NLRP3 inflammasome","volume":"116","author":"Kuipers","year":"2012","journal-title":"Anesthesiology"},{"key":"pmeaaa9052bib037","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s00134-016-4571-5","type":"journal-article","article-title":"Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study","volume":"42","author":"Laffey","year":"2016","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib038","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2110-5820-4-1","type":"journal-article","article-title":"Lung ultrasound in the critically ill","volume":"4","author":"Lichtenstein","year":"2014","journal-title":"Ann. Intensive Care"},{"key":"pmeaaa9052bib039","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13054-016-1300-y","type":"journal-article","article-title":"Identification of regional overdistension, recruitment and cyclic alveolar collapse with electrical impedance tomography in an experimental ARDS model","volume":"20","author":"Liu","year":"2016","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4187\/respcare.05500055","type":"journal-article","article-title":"Respiratory mechanics derived from signals in the ventilator circuit","volume":"50","author":"Lucangelo","year":"2005","journal-title":"Respir. Care"},{"key":"pmeaaa9052bib041","doi-asserted-by":"publisher","first-page":"S247","DOI":"10.1088\/0967-3334\/28\/7\/S18","type":"journal-article","article-title":"Protective ventilation using electrical impedance tomography","volume":"28","author":"Luepschen","year":"2007","journal-title":"Physiol. Meas."},{"key":"pmeaaa9052bib042","doi-asserted-by":"publisher","first-page":"22s","DOI":"10.1183\/09031936.03.00004204","type":"journal-article","article-title":"What has been learnt from P\/V curves in patients with acute lung injury\/acute respiratory distress syndrome","volume":"42","author":"Maggiore","year":"2003","journal-title":"Eur. Respir. J. Suppl."},{"key":"pmeaaa9052bib043","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/BF00255628","type":"journal-article","article-title":"Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study","volume":"15","author":"Mascheroni","year":"1988","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib044","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1378\/chest.86.1.58","type":"journal-article","article-title":"Total respiratory pressure\u2013volume curves in the adult respiratory distress syndrome","volume":"86","author":"Matamis","year":"1984","journal-title":"Chest"},{"key":"pmeaaa9052bib045","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1097\/CCM.0b013e318287f6e7","type":"journal-article","article-title":"Topographic distribution of tidal ventilation in acute respiratory distress syndrome: effects of positive end-expiratory pressure and pressure support","volume":"41","author":"Mauri","year":"2013","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib046","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1097\/CCM.0000000000001083","type":"journal-article","article-title":"Effects of Sigh on regional lung strain and ventilation heterogeneity in acute respiratory failure patients undergoing assisted mechanical ventilation","volume":"43","author":"Mauri","year":"2015","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib047","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1007\/s00134-016-4400-x","type":"journal-article","article-title":"Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives","volume":"42","author":"PLeUral pressure working Group (PLUG-Acute Respiratory Failure section of the ESICM)","year":"2016","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib048","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1164\/rccm.201609-1806IM","type":"journal-article","article-title":"Effects of variable pressure support ventilation on regional homogeneity and aeration","volume":"195","author":"Mauri","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib049","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1152\/jappl.1970.28.5.596","type":"journal-article","article-title":"Stress distribution in lungs: a model of pulmonary elasticity","volume":"28","author":"Mead","year":"1970","journal-title":"J. Appl. Physiol."},{"key":"pmeaaa9052bib050","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s00134-003-2109-0","type":"journal-article","article-title":"Lung volume in mechanically ventilated patients: measurement by simplified helium dilution compared to quantitative CT scan","volume":"30","author":"Patroniti","year":"2004","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib051","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1007\/s00134-008-1218-1","type":"journal-article","article-title":"Measurement of end-expiratory lung volume by oxygen washin-washout in controlled and assisted mechanically ventilated patients","volume":"34","author":"Patroniti","year":"2008","journal-title":"Intensive Care Med."},{"key":"pmeaaa9052bib052","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1097\/CCM.0b013e3181d8cb51","type":"journal-article","article-title":"Role of absolute lung volume to assess alveolar recruitment in acute respiratory distress syndrome patients","volume":"38","author":"Patroniti","year":"2010","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib053","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1164\/ajrccm.152.2.7633703","type":"journal-article","article-title":"Alterations of lung and chest wall mechanics in patients with acute lung injury: effects of positive end-expiratory pressure","volume":"152","author":"Pelosi","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib054","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1164\/ajrccm\/144.1.101","type":"journal-article","article-title":"The effects of positive end-expiratory pressure on respiratory resistance in patients with the adult respiratory distress syndrome and in normal anesthetized subjects","volume":"144","author":"Pesenti","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"pmeaaa9052bib055","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1164\/ajrccm\/144.3_Pt_1.544","type":"journal-article","article-title":"Effects of positive end-expiratory pressure on alveolar recruitment and gas exchange in patients with the adult respiratory distress syndrome","volume":"144","author":"Ranieri","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"pmeaaa9052bib056","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/cc13100","type":"journal-article","article-title":"Nitrogen washout\/washin, helium dilution, and computed tomography in the assessment of end-expiratory lung volume","volume":"17","author":"Richard","year":"2013","journal-title":"Crit. Care"},{"key":"pmeaaa9052bib057","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/MCC.0000000000000268","type":"journal-article","article-title":"The promises and problems of transpulmonary pressure measurements in acute respiratory distress syndrome","volume":"22","author":"Sahetya","year":"2016","journal-title":"Curr. Opin. Crit. Care"},{"key":"pmeaaa9052bib058","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1056\/NEJMra1208707","type":"journal-article","article-title":"Ventilator-induced lung injury","volume":"369","author":"Slutsky","year":"2013","journal-title":"New Engl. J. Med."},{"key":"pmeaaa9052bib059","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1152\/jappl.1988.65.4.1488","type":"journal-article","article-title":"Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction","volume":"65","author":"Smith","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"pmeaaa9052bib060","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1097\/01.CCM.0000227220.67613.0D","type":"journal-article","article-title":"Dynamic versus static respiratory mechanics in acute lung injury and acute respiratory distress syndrome","volume":"34","author":"Stahl","year":"2006","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib061","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/MCC.0b013e3282f3a166","type":"journal-article","article-title":"Dynamic respiratory mechanics in acute lung injury\/acute respiratory distress syndrome: research or clinical tool","volume":"14","author":"Stenqvist","year":"2008","journal-title":"Curr. Opin. Crit. Care"},{"key":"pmeaaa9052bib062","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1056\/NEJMoa0708638","type":"journal-article","article-title":"Mechanical ventilation guided by esophageal pressure in acute lung injury","volume":"359","author":"Talmor","year":"2008","journal-title":"New Engl. J. Med."},{"key":"pmeaaa9052bib063","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1164\/rccm.200607-915OC","type":"journal-article","article-title":"Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome","volume":"175","author":"Terragni","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib064","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1097\/ALN.0b013e3181b764d2","type":"journal-article","article-title":"Tidal volume lower than 6\u2009ml kg\u22121 enhances lung protection: role of extracorporeal carbon dioxide removal","volume":"111","author":"Terragni","year":"2009","journal-title":"Anesthesiology"},{"key":"pmeaaa9052bib065","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/01.CCM.0000150660.45376.7C","type":"journal-article","article-title":"Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?","volume":"33","author":"Valenza","year":"2005","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib067","doi-asserted-by":"publisher","first-page":"e491","DOI":"10.1097\/CCM.0000000000000346","type":"journal-article","article-title":"Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep","volume":"42","author":"Wellman","year":"2014","journal-title":"Crit. Care Med."},{"key":"pmeaaa9052bib068","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1378\/chest.106.5.1517","type":"journal-article","article-title":"Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS)","volume":"106","author":"Wright","year":"1994","journal-title":"Chest"},{"key":"pmeaaa9052bib069","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1164\/rccm.201303-0539OC","type":"journal-article","article-title":"Spontaneous effort causes occult pendelluft during mechanical ventilation","volume":"188","author":"Yoshida","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib0001a","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1164\/rccm.201610-1972OC","type":"journal-article","article-title":"Volume-controlled ventilation does not prevent injurious inflation during spontaneous effort","volume":"196","author":"Yoshida","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"pmeaaa9052bib070","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/cc8860","type":"journal-article","article-title":"PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography","volume":"14","author":"Zhao","year":"2010","journal-title":"Crit. Care"}],"container-title":["Physiological Measurement"],"original-title":[],"link":[{"URL":"http:\/\/stacks.iop.org\/0967-3334\/38\/i=12\/a=R280?key=crossref.ba992c964bc8e27bb339efd753b44e13","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/38\/i=12\/a=R280\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/38\/i=12\/a=R280\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/38\/i=12\/a=R280?key=crossref.ba992c964bc8e27bb339efd753b44e13","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:31:17Z","timestamp":1784982677000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/aa9052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":69,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,11,28]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6579\/aa9052","relation":{},"ISSN":["0967-3334","1361-6579"],"issn-type":[{"value":"0967-3334","type":"print"},{"value":"1361-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]},"assertion":[{"value":"Respiratory mechanics to understand ARDS and guide mechanical ventilation","name":"article_title","label":"Article Title"},{"value":"Physiological Measurement","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2017 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-04-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-10-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-11-28","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}