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Meas."],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : We determined if transcranial color-coded Doppler derived hemodynamics are associated with MRI-based cerebral blood flow (CBF) in regions clinically important to dementia in healthy middle-aged adults.\n                    <jats:italic>Approach<\/jats:italic>\n                    : In 30 subjects (18m\/12f; age\u2009\u2009=\u2009\u200952\u2009\u2009\u00b1\u2009\u20091 years), blood flow velocity (BFV) and cerebrovascular conductance (CVC) were measured with transcranial color-coded Doppler (TCCD) at the middle cerebral artery (MCA) and cerebral blood flow (CBF) was assessed with arterial spin labeled perfusion MRI.\n                    <jats:italic>Main results<\/jats:italic>\n                    : BFV and CVC were associated with hippocampus (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.58 and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.61, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.01) and occipitoparietal (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.50 and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.58, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.01) CBF. CVC was further associated with posterior cingulate CBF (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.58\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.01). Independent of age and sex, BFV and CVC were associated with hippocampus (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.59 and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.55, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.003) and occipitoparietal (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.50 and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.57, both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.01) CBF. CVC was independently associated with posterior cingulate CBF (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.049).\n                    <jats:italic>Significance<\/jats:italic>\n                    : TCCD-measured BFV and CVC of the MCA are indicators of cerebral perfusion to clinically valuable brain regions in healthy middle-aged adults. TCCD may not be a good indicator of blood flow to cerebral white matter.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aa976f","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T10:45:18Z","timestamp":1509533118000},"page":"2176-2185","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Transcranial Doppler of the middle cerebral artery indicates regional gray matter cerebral perfusion"],"prefix":"10.1088","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-5844","authenticated-orcid":false,"given":"Evan P","family":"Pasha","sequence":"first","affiliation":[{"name":"The University of Texas at Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tarumi","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreana P","family":"Haley","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"},{"name":"The University of Texas at Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"pmeaaa976fbib001","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1161\/01.STR.20.1.45","type":"journal-article","article-title":"Cerebral autoregulation dynamics in humans","volume":"20","author":"Aaslid","year":"1989","journal-title":"Stroke"},{"key":"pmeaaa976fbib002","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3171\/jns.1982.57.6.0769","type":"journal-article","article-title":"Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries","volume":"57","author":"Aaslid","year":"1982","journal-title":"J. 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