{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:36:26Z","timestamp":1785393386924,"version":"3.55.0"},"reference-count":29,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"tdm","delay-in-days":25,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005416","name":"The Research Council of Norway","doi-asserted-by":"crossref","award":["Integrisc\/219819"],"award-info":[{"award-number":["Integrisc\/219819"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sensocure AS"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : Trans-intestinal bioimpedance measurements have previously been used to investigate changes in electrical parameters during 6\u2009h of ischemia in the small intestine. Knowledge is lacking regarding the time course of trans-intestinal bioimpedance parameters during reperfusion. As reperfusion is an important part in the clinical treatment of intestinal ischemia, we need to know how it affects the bioimpedance measurements.\n                    <jats:italic>Approach<\/jats:italic>\n                    : We performed bioimpedance measurements, using a two-electrode setup on selected segments of the jejunum in 15 pigs. A controlled voltage signal was applied while measuring the resulting current. In each pig, five or six 30\u2009cm segments of the jejunum were made ischemic by clamping the mesenteric arteries and veins creating segments with ischemia from 1\u201316\u2009h duration. Reperfusion was initiated at selected time intervals of ischemia, and measured for 5\u201315\u2009h afterwards.\n                    <jats:italic>Main results<\/jats:italic>\n                    : The tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    parameter (loss tangent) was different (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.016) comparing ischemic and control tissue for the duration of the experiment (16\u2009h). Comparing the control tissue 30\u2009cm from the ischemic area with the control tissue 60\u2009cm from the ischemic tissue, we found that the mean tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    amplitude in the frequency range (3900\u20136300 Hz) was significantly higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&lt;\u2009\u20090.036) in the proximal control after 10\u2009h of experiment duration. After reperfusion, the time development of tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    m (loss tangent maximum over a frequency range) amplitude and frequency overlapped and periodically increased above the tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    m in the ischemic intestine. Dependent on the ischemic duration pre-reperfusion, the initial increase in tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    stabilizes or increases drastically over time, compared to the tan\n                    <jats:italic>\u03b4<\/jats:italic>\n                    amplitude of the ischemic tissue.\n                    <jats:italic>Significance<\/jats:italic>\n                    : As during ischemia, the electrical parameters during reperfusion also follow a characteristic time-course, depending on the ischemic exposure before pre-reperfusion. The temporal changes in electrical parameters during small intestinal ischemia followed by reperfusion provides important information for assessment of tissue injury.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aaa576","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T08:30:49Z","timestamp":1515141049000},"page":"025001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Small intestinal ischemia and reperfusion\u2014bioimpedance measurements"],"prefix":"10.1088","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-9355","authenticated-orcid":false,"given":"Runar J","family":"Strand-Amundsen","sequence":"first","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"},{"name":"University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Tronstad","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Kalv\u00f8y","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom E","family":"Ruud","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"},{"name":"Baerum Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan O","family":"H\u00f8getveit","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"},{"name":"University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8rjan G","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"},{"name":"University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor I","family":"T\u00f8nnessen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2014Rikshospitalet"},{"name":"University of Oslo\u2014Rikshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"pmeaaaa576bib001","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1177\/1535370215571876","type":"journal-article","article-title":"Gastrointestinal ischemia monitoring through impedance spectroscopy as a tool for the management of the critically ill","volume":"240","author":"Beltran","year":"2015","journal-title":"Exp. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-11-12","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-01-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-02-26","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}