{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:04:41Z","timestamp":1779541481848,"version":"3.53.1"},"reference-count":37,"publisher":"IOP Publishing","issue":"7","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":31,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : It has been documented that heart transplantation in children is often complicated by arterial hypertension and increased arterial stiffness. We use innovative multi-site photoplethysmography (MPPG) pulse measurement and analysis technology to assess changes in arterial stiffness in paediatric heart transplant recipients (HTRs) in comparison with healthy control (HC) children.\n                    <jats:italic>Approach<\/jats:italic>\n                    : A group of 20 HTRs (median age 13.5 years, eight male) were compared to an overall age- and gender-matched group of 161 HCs (median age 11.6 years, 74 male). Peripheral pulse was recorded bilaterally using MPPG at the ear lobe, index finger and great toe sites, along with an electrocardiogram cardiac timing reference. Segmental pulse arrival times between peripheral sites (finger\u2013ear, PATf\u2013e; toe\u2013finger, PATt\u2013f; and toe\u2013ear PATt\u2013e) were calculated as arterial stiffness measures, and differences between subject groups were tested using multivariate analysis. Normalised ear, finger and toe pulse shapes were also studied and compared between groups.\n                    <jats:italic>Main results<\/jats:italic>\n                    : After correction for heart rate and diastolic and mean arterial blood pressures, the HTR group was found to have significantly lower segmental PATt\u2013e and PATt\u2013f measurements, with median values of 150\u2009ms versus 172\u2009ms in the HC group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.02), and 104 ms versus 118 ms in the HC group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009=\u2009\u20090.01), respectively, consistent with increased arterial stiffness in the patient group. The normalised ear, finger and toe sites showed only a mild elongation in each pulse rise time for the transplant group.\n                    <jats:italic>Significance<\/jats:italic>\n                    : This study shows that innovative and easy-to-do MPPG gives further evidence for increased arterial stiffness in children who have undergone successful cardiac transplantation.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aac76a","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T12:15:15Z","timestamp":1527077715000},"page":"074007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Innovative multi-site photoplethysmography measurement and analysis demonstrating increased arterial stiffness in paediatric heart transplant recipients"],"prefix":"10.1088","volume":"39","author":[{"given":"Emma J","family":"Sharkey","sequence":"first","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering"},{"name":"Freeman Hospital"},{"name":"Sharkey and Di Maria to be assigned as joint first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanzo","family":"Di Maria","sequence":"additional","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering"},{"name":"Newcastle University"},{"name":"Sharkey and Di Maria to be assigned as joint first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Klinge","sequence":"additional","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering"},{"name":"Freeman Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Murray","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingchang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Freeman Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Allen","sequence":"additional","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering"},{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"pmeaaac76abib001","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1088\/0967-3334\/28\/3\/R01","type":"journal-article","article-title":"Photoplethysmography and its application in clinical physiological measurement","volume":"28","author":"Allen","year":"2007","journal-title":"Physiol. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-02-03","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-05-23","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-08-01","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}