{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:05:25Z","timestamp":1779541525821,"version":"3.53.1"},"reference-count":26,"publisher":"IOP Publishing","issue":"7","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"tdm","delay-in-days":18,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : The ductus arteriosus is a blood vessel that connects the pulmonary artery to the descending aorta during fetal life and generally undergoes spontaneous closure shortly after birth. In premature neonates it often fails to close (patent ductus arteriosus\u2014PDA), which can result in diversion of a significant part of the left-ventricular cardiac output to the pulmonary circulation. This left-to-right shunt may result in significant increase of pulmonary blood flow and decrease of systemic perfusion (hemodynamically significant PDA\u2014hsPDA), which may lead to severe neonatal morbidity. The study objective was to find the relationship between hsPDA and perfusion index (PI), a photoplethysmographic parameter related to systemic perfusion.\n                    <jats:italic>Approach<\/jats:italic>\n                    : PI measures the relative systolic increase in tissue light absorption due to the systolic increase in the tissue blood volume. PI has been found to be directly related to tissue perfusion and is therefore expected to be affected by hsPDA.\n                    <jats:italic>Main results<\/jats:italic>\n                    : PI was found to be higher in preterm neonates with hsPDA after first week of life, in comparison to those with closed DA, despite the lower systemic perfusion, probably due to reverse flow during diastole.\n                    <jats:italic>Significance<\/jats:italic>\n                    : In our study, perfusion index increased despite the lower systemic perfusion, indicating that in neonates with hsPDA, perfusion index is not necessarily a measure of perfusion. Nevertheless, PI can be used as a screening tool for suspicious PDA, in order to select a relatively small group of neonates for a more definitive examination by echocardiography, which is not suitable for universal screening.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aacf25","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:45:16Z","timestamp":1529999116000},"page":"075006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of patent ductus arteriosus on pre-ductal and post-ductal perfusion index in preterm neonates"],"prefix":"10.1088","volume":"39","author":[{"given":"Itamar","family":"Nitzan","sequence":"first","affiliation":[{"name":"Shaare Zedek Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Hammerman","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center"},{"name":"Hebrew University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fink","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir","family":"Nitzan","sequence":"additional","affiliation":[{"name":"Jerusalem College of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koppel","sequence":"additional","affiliation":[{"name":"Cohen Children\u2019s Medical Center of New York\/Northwell Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Bromiker","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center"},{"name":"Hebrew University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"pmeaaacf25bib001","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000370192","type":"journal-article","article-title":"Perfusion index in preterm infants during the first 3 days of life: reference values and relation with clinical variables","volume":"107","author":"Alderliesten","year":"2015","journal-title":"Neonatology"},{"key":"pmeaaacf25bib002","article-title":"Effect of ductus arteriosus closure on photoplethysmographic signals in preterm infants","author":"Amirtharaj","year":"2015","type":"other"},{"key":"pmeaaacf25bib003","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/nbm.2927","type":"journal-article","article-title":"Assessment of PDA shunt and systemic blood flow in newborns using cardiac MRI","volume":"26","author":"Broadhouse","year":"2013","journal-title":"NMR Biomed."},{"key":"pmeaaacf25bib004","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-1-4377-2763-0.00013-5","type":"book","article-title":"The very low birth weight neonate with hemodynamically significant ductus arteriosus during the first postnatal week","author":"Clyman","year":"2012","edition":"2nd edn"},{"key":"pmeaaacf25bib005","doi-asserted-by":"publisher","first-page":"F411","DOI":"10.1136\/adc.2004.068882","type":"journal-article","article-title":"Early postnatal changes in the perfusion index in term newborns with subclinical chorioamnionitis","volume":"90","author":"De Felice","year":"2005","journal-title":"Arch. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-02-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-06-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-07-19","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}