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Meas."],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : To evaluate whether detrended fluctuation analysis (DFA) provides information that improves the diagnostic ability of the oximetry signal in the diagnosis of paediatric sleep apnoea\u2013hypopnoea syndrome (SAHS).\n                    <jats:italic>Approach<\/jats:italic>\n                    : A database composed of 981 blood oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ) recordings in children was used to extract DFA-derived features in order to quantify the scaling behaviour and the fluctuations of the SpO\n                    <jats:sub>2<\/jats:sub>\n                    signal. The 3% oxygen desaturation index (\n                    <jats:italic>ODI<\/jats:italic>\n                    3) was also computed for each subject. Fast correlation-based filter (FCBF) was then applied to select an optimum subset of relevant and non-redundant features. This subset fed a multi-layer perceptron (MLP) neural network to estimate the apnoea\u2013hypopnoea index (AHI).\n                    <jats:italic>Main results<\/jats:italic>\n                    :\n                    <jats:italic>ODI<\/jats:italic>\n                    3 and four features from the DFA reached significant differences associated with the severity of SAHS. An optimum subset composed of the slope in the first scaling region of the DFA profile and the\n                    <jats:italic>ODI<\/jats:italic>\n                    3 was selected using FCBF applied to the training set (60% of samples). The MLP model trained with this feature subset showed good agreement with the actual AHI, reaching an intra-class correlation coefficient of 0.891 in the test set (40% of samples). Furthermore, the estimated AHI showed high diagnostic ability, reaching an accuracy of 82.7%, 81.9%, and 91.1% using three common AHI cut-offs of 1, 5, and 10 events per hour (e h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), respectively. These results outperformed the overall performance of\n                    <jats:italic>ODI<\/jats:italic>\n                    3.\n                    <jats:italic>Significance<\/jats:italic>\n                    : DFA may serve as a reliable tool to improve the diagnostic performance of oximetry recordings in the evaluation of paediatric patients with symptoms suggestive of SAHS.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/aae66a","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T18:19:07Z","timestamp":1538763547000},"page":"114006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Detrended fluctuation analysis of the oximetry signal to assist in paediatric sleep apnoea\u2013hypopnoea syndrome diagnosis"],"prefix":"10.1088","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-2006","authenticated-orcid":false,"given":"Fernando","family":"Vaquerizo-Villar","sequence":"first","affiliation":[{"name":"Universidad de Valladolid"},{"name":"Author to whom any correspondence should be addressed."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-2395","authenticated-orcid":false,"given":"Daniel","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"},{"name":"Hospital Universitario Rio Hortega"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kheirandish-Gozal","sequence":"additional","affiliation":[{"name":"The University of Missouri School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-3424","authenticated-orcid":false,"given":"Gonzalo C","family":"Guti\u00e9rrez-Tobal","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-206X","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Barroso-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Crespo","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"},{"name":"Hospital Universitario Rio Hortega"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-2167","authenticated-orcid":false,"given":"F\u00e9lix","family":"del Campo","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"},{"name":"Hospital Universitario Rio Hortega"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8195-6036","authenticated-orcid":false,"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"The University of Missouri School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-2570","authenticated-orcid":false,"given":"Roberto","family":"Hornero","sequence":"additional","affiliation":[{"name":"Universidad de Valladolid"},{"name":"Universidad de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"pmeaaae66abib001","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0300-2896(11)70026-6","type":"journal-article","article-title":"Documento de consenso del s\u00edndrome de apneas-hipopneas durante el sue\u00f1o en ni\u00f1os","volume":"47","author":"Alonso-\u00c1lvarez","year":"2011","journal-title":"Arch. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-07-20","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-10-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-11-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}