{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:46:20Z","timestamp":1772325980308,"version":"3.50.1"},"reference-count":59,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"tdm","delay-in-days":24,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Astonish project","award":["H2020 ECSEL2015\u2014692470"],"award-info":[{"award-number":["H2020 ECSEL2015\u2014692470"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : Alzheimer\u2019s disease (AD) is characterized by progressive memory failures and visuospatial impairment. Moreover, AD can be accompanied by autonomic system alterations, which, among other impacts, affect thermoregulatory activity. We here investigate differences in autonomic activity between AD patients and healthy controls (HC), employing a complexity analysis of functional infrared imaging (fIRI) data acquired at rest and during the execution of clinical cognitive and mnemonic tests.\n                    <jats:italic>Approach<\/jats:italic>\n                    : fIRI allows for contactless monitoring of autonomic activity and its thermoregulatory expression without interfering with the psychophysiological state of the subject, preserving free interaction with the doctor. The signal complexity analysis, based on the sample entropy, was compared to a standard frequency-based analysis of autonomic-related signals.\n                    <jats:italic>Main results<\/jats:italic>\n                    : AD patients exhibited lower complexity of fIRI signals during the tests, which could be indicative of a stronger sympathetic activity with respect to HC. No significant effects were found at rest. No differences were found on employing frequency-based analysis.\n                    <jats:italic>Significance<\/jats:italic>\n                    : This study confirms that AD patients may exhibit peculiar autonomic responses associated with the execution of cognitive tasks that can be measured through fIRI. Moreover, these responses could be highlighted by a nonlinear metric of signal predictability such as the sample entropy establishing autonomic impairment of AD patients.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/ab057d","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T18:26:21Z","timestamp":1549650381000},"page":"034002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Autonomic impairment in Alzheimer\u2019s disease is revealed by complexity analysis of functional thermal imaging signals during cognitive tasks"],"prefix":"10.1088","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-0501","authenticated-orcid":false,"given":"David","family":"Perpetuini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cardone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-8417","authenticated-orcid":false,"given":"Antonio Maria","family":"Chiarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Croce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Zappasodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Rotunno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Anzoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Zito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangelo","family":"Merla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"pmeaab057dbib001","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1088\/0967-3334\/27\/3\/003","type":"journal-article","article-title":"Entropy analysis of the EEG background activity in Alzheimer\u2019s disease patients","volume":"27","author":"Ab\u00e1solo","year":"2006","journal-title":"Physiol. Meas."},{"key":"pmeaab057dbib002","doi-asserted-by":"publisher","first-page":"5942","DOI":"10.1109\/IEMBS.2007.4353701","type":"other","article-title":"Characterization of sample entropy in the context of biomedical signal analysis","author":"Aboy","year":"2007"},{"key":"pmeaab057dbib003","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1111\/jgs.12553","type":"journal-article","article-title":"Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer\u2019s disease: a scoping review of the evidence","volume":"61","author":"Affoo","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"pmeaab057dbib004","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1001\/archneur.1992.00530330041013","type":"journal-article","article-title":"Increased sympathetic and decreased parasympathetic cardiac innervation in patients with Alzheimer\u2019s disease","volume":"49","author":"Aharon-Peretz","year":"1992","journal-title":"Arch. Neurol."},{"key":"pmeaab057dbib005","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1109\/TBME.2006.889772","type":"journal-article","article-title":"Use of sample entropy approach to study heart rate variability in obstructive sleep apnea syndrome","volume":"54","author":"Al-Angari","year":"2007","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"pmeaab057dbib006","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1600-0404.1995.tb05836.x","type":"journal-article","article-title":"Autonomic dysfunction in Alzheimer\u2019s disease","volume":"91","author":"Algotsson","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"pmeaab057dbib007","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/23328940.2015.1095270","type":"journal-article","article-title":"Current understanding on the neurophysiology of behavioral thermoregulation","volume":"2","author":"Almeida","year":"2015","journal-title":"Temperature"},{"key":"pmeaab057dbib0001a","author":"American Psychiatric Association","year":"2003","edition":"5th edn","type":"book"},{"key":"pmeaab057dbib008","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1749-6632.2002.tb04560.x","type":"journal-article","article-title":"Assessment of physiologic and pathologic radiative heat dissipation using dynamic infrared imaging","volume":"972","author":"Anbar","year":"2002","journal-title":"Ann. New York Acad. Sci."},{"key":"pmeaab057dbib009","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1093\/brain\/114.6.2521","type":"journal-article","article-title":"The decline of working memory in Alzheimer\u2019s disease: a longitudinal study","volume":"114","author":"Baddeley","year":"1991","journal-title":"Brain"},{"key":"pmeaab057dbib010","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.acn.2005.07.002","type":"journal-article","article-title":"Executive function deficits in early Alzheimer\u2019s disease and their relations with episodic memory","volume":"21","author":"Baudic","year":"2006","journal-title":"Arch. Clin. Neuropsychol."},{"key":"pmeaab057dbib011","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1037\/0894-4105.12.1.29","type":"journal-article","article-title":"Visual and spatial perception in the early phase of Alzheimer\u2019s disease","volume":"12","author":"Binetti","year":"1998","journal-title":"Neuropsychology"},{"key":"pmeaab057dbib012","doi-asserted-by":"publisher","first-page":"M8","DOI":"10.1093\/geronj\/44.1.M8","type":"journal-article","article-title":"Impaired sympathetic nervous system response to cognitive effort in early Alzheimer\u2019s disease","volume":"44","author":"Borson","year":"1989","journal-title":"J. Gerontol."},{"key":"pmeaab057dbib013","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/s17051042","type":"journal-article","article-title":"New frontiers for applications of thermal infrared imaging devices: computational psychopshysiology in the neurosciences","volume":"17","author":"Cardone","year":"2017","journal-title":"Sensors"},{"key":"pmeaab057dbib014","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/23328940.2015.1096438","type":"journal-article","article-title":"Temperature and toxic Tau in Alzheimer\u2019s disease: new insights","volume":"2","author":"Carrettiero","year":"2015","journal-title":"Temperature"},{"key":"pmeaab057dbib015","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/1754073914554783","type":"journal-article","article-title":"Infrared thermography as a measure of emotion response","volume":"7","author":"Clay-Warner","year":"2015","journal-title":"Emotion Rev."},{"key":"pmeaab057dbib016","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1532-5415.1986.tb06334.x","type":"journal-article","article-title":"Dementia of the Alzheimer type: an inventory of diagnostic clinical features","volume":"34","author":"Cummings","year":"1986","journal-title":"J. Am. Geriatr. Soc."},{"key":"pmeaab057dbib017","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.mcna.2013.01.001","type":"journal-article","article-title":"International work group criteria for the diagnosis of Alzheimer disease","volume":"97","author":"Cummings","year":"2013","journal-title":"Med. Clin."},{"key":"pmeaab057dbib018","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1201\/b12938","type":"book","author":"Diakides","year":"2012"},{"key":"pmeaab057dbib019","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1532-5415.1991.tb02502.x","type":"journal-article","article-title":"Thermoregulatory behavior in Alzheimer\u2019s disease","volume":"39","author":"Diamond","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"pmeaab057dbib020","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","type":"journal-article","article-title":"Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS-ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol."},{"key":"pmeaab057dbib021","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1088\/0967-3334\/27\/11\/004","type":"journal-article","article-title":"Analysis of electroencephalograms in Alzheimer\u2019s disease patients with multiscale entropy","volume":"27","author":"Escudero","year":"2006","journal-title":"Physiol. Meas."},{"key":"pmeaab057dbib022","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1037\/1528-3542.7.2.336","type":"journal-article","article-title":"Anxiety and cognitive performance: attentional control theory","volume":"7","author":"Eysenck","year":"2007","journal-title":"Emotion"},{"key":"pmeaab057dbib023","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3233\/JAD-140513","type":"journal-article","article-title":"Autonomic dysfunction in Alzheimer\u2019s disease: tools for assessment and review of the literature","volume":"42","author":"Femminella","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"pmeaab057dbib024","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.infrared.2015.02.007","type":"journal-article","article-title":"Classification of factors influencing the use of infrared thermography in humans: a review","volume":"71","author":"Fern\u00e1ndez-Cuevas","year":"2015","journal-title":"Infrared Phys. Technol."},{"key":"pmeaab057dbib025","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","type":"journal-article","article-title":"\u2018Mini-mental state\u2019: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatric Res."},{"key":"pmeaab057dbib026","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1109\/TBME.2007.891930","type":"journal-article","article-title":"Contact-free measurement of cardiac pulse based on the analysis of thermal imagery","volume":"54","author":"Garbey","year":"2007","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"pmeaab057dbib027","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0169-8141(96)00011-X","type":"journal-article","article-title":"Using facial skin temperature to objectively evaluate sensations","volume":"19","author":"Genno","year":"1997","journal-title":"Int. J. Ind. Ergon."},{"key":"pmeaab057dbib028","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s10439-008-9633-6","type":"journal-article","article-title":"Analysis of MEG background activity in Alzheimer\u2019s disease using nonlinear methods and ANFIS","volume":"37","author":"G\u00f3mez","year":"2009","journal-title":"Ann. Biomed. Eng."},{"key":"pmeaab057dbib029","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1088\/0967-3334\/26\/4\/016","type":"journal-article","article-title":"Nonlinear characteristics of heart rate time series: influence of three recumbent positions in patients with mild or severe coronary artery disease","volume":"26","author":"Kim","year":"2005","journal-title":"Physiol. Meas."},{"key":"pmeaab057dbib030","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000095386","type":"journal-article","article-title":"Increase in core body temperature of Alzheimer\u2019s disease patients as a possible indicator of chronic neuroinflammation: a meta-analysis","volume":"53","author":"Klegeris","year":"2007","journal-title":"Gerontology"},{"key":"pmeaab057dbib031","doi-asserted-by":"publisher","first-page":"R789","DOI":"10.1152\/ajpregu.00069.2002","type":"journal-article","article-title":"Sample entropy analysis of neonatal heart rate variability","volume":"283","author":"Lake","year":"2002","journal-title":"Am. J. Physiol."},{"key":"pmeaab057dbib032","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","type":"journal-article","article-title":"Heart rate variability: standards of measurement, physiological interpretation, and clinical use","volume":"17","author":"Malik","year":"1996","journal-title":"Eur. Heart J."},{"key":"pmeaab057dbib033","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/hrt.71.1.1","type":"journal-article","article-title":"Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms","volume":"71","author":"Malliani","year":"1994","journal-title":"Br. Heart J."},{"key":"pmeaab057dbib034","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fnhum.2013.00299","type":"journal-article","article-title":"Mom feels what her child feels: thermal signatures of vicarious autonomic response while watching children in a stressful situation","volume":"7","author":"Manini","year":"2013","journal-title":"Frontiers Hum. Neurosci."},{"key":"pmeaab057dbib035","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.infrared.2015.05.008","type":"journal-article","article-title":"Circadian and gender differences in skin temperature in militaries by thermography","volume":"71","author":"Marins","year":"2015","journal-title":"Infrared Phys. Technol."},{"key":"pmeaab057dbib036","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1109\/IEMBS.2005.1616507","type":"conference-proceedings","article-title":"Biomedical applications of functional infrared imaging","author":"Merla","year":"2006"},{"key":"pmeaab057dbib037","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13084","type":"journal-article","article-title":"Thermoregulatory profile of neurodegeneration\u2010induced dementia of the Alzheimer\u2019s type using intracerebroventricular streptozotocin in rats","volume":"224","author":"Motzko\u2010Soares","year":"2018","journal-title":"Acta Physiol."},{"key":"pmeaab057dbib038","first-page":"1021","type":"journal-article","article-title":"Le test de copie d\u2019une figure complex: Contribution a l\u2019etude de la perception et de la memoire (the complex figure test: contribution to the study of perception and memory)","volume":"28","author":"Osterrieth","year":"1944","journal-title":"Arch. Psychol."},{"key":"pmeaab057dbib039","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.5.1.011010","type":"journal-article","article-title":"Study of memory deficit in Alzheimer\u2019s disease by means of complexity analysis of fNIRS signal","volume":"5","author":"Perpetuini","year":"2017","journal-title":"Neurophotonics"},{"key":"pmeaab057dbib040","doi-asserted-by":"publisher","first-page":"951","DOI":"10.2174\/1871529X18666180503125428","type":"journal-article","article-title":"Assessment of the autonomic response in Alzheimer\u2019s patients during the execution of memory tasks: a functional thermal imaging study","volume":"15","author":"Perpetuini","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"pmeaab057dbib041","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/e21010026","type":"journal-article","article-title":"Complexity of frontal cortex fNIRS can support Alzheimer disease diagnosis in memory and visuo-spatial tests","volume":"21","author":"Perpetuini","year":"2019","journal-title":"Entropy"},{"key":"pmeaab057dbib042","doi-asserted-by":"publisher","first-page":"H1643","DOI":"10.1152\/ajpheart.1994.266.4.H1643","type":"journal-article","article-title":"Physiological time-series analysis: what does regularity quantify?","volume":"266","author":"Pincus","year":"1994","journal-title":"Am. J. Physiol."},{"key":"pmeaab057dbib043","doi-asserted-by":"publisher","author":"Prinz","year":"1992","DOI":"10.1177\/002383099200500202","type":"book"},{"key":"pmeaab057dbib044","first-page":"223","type":"book","article-title":"Raven progressive matrices","author":"Raven","year":"2003"},{"key":"pmeaab057dbib045","first-page":"215","type":"journal-article","article-title":"L\u2019examen psychologique dans les cas d\u2019enc\u00e9phalopathie traumatique (Les problems)","volume":"28","author":"Rey","year":"1941","journal-title":"Arch. Psychol."},{"key":"pmeaab057dbib046","doi-asserted-by":"publisher","first-page":"H2039","DOI":"10.1152\/ajpheart.2000.278.6.H2039","type":"journal-article","article-title":"Physiological time-series analysis using approximate entropy and sample entropy","volume":"278","author":"Richman","year":"2000","journal-title":"Am. J. Physiol."},{"key":"pmeaab057dbib047","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1088\/0967-3334\/33\/3\/R33","type":"journal-article","article-title":"Infrared thermal imaging in medicine","volume":"33","author":"Ring","year":"2012","journal-title":"Physiol. Meas."},{"key":"pmeaab057dbib048","first-page":"51","type":"journal-article","article-title":"Clinical and neuropsychological assessment of Alzheimer disease","volume":"38","author":"Rosen","year":"1983","journal-title":"Adv. Neurol."},{"key":"pmeaab057dbib049","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.concog.2015.04.003","type":"journal-article","article-title":"The mental and subjective skin: emotion, empathy, feelings and thermography","volume":"34","author":"Salazar-L\u00f3pez","year":"2015","journal-title":"Conscious. Cogn."},{"key":"pmeaab057dbib050","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/0197-4580(95)00059-N","type":"journal-article","article-title":"Circadian locomotor activity and core-body temperature rhythms in Alzheimer\u2019s disease","volume":"16","author":"Satlin","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"pmeaab057dbib051","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.pscychresns.2013.10.001","type":"journal-article","article-title":"Resting state fMRI entropy probes complexity of brain activity in adults with ADHD","volume":"214","author":"Sokunbi","year":"2013","journal-title":"Psychiatry Res."},{"key":"pmeaab057dbib052","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095146","type":"journal-article","article-title":"Nonlinear complexity analysis of brain fMRI signals in schizophrenia","volume":"9","author":"Sokunbi","year":"2014","journal-title":"PLOS One"},{"key":"pmeaab057dbib053","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1159\/000212774","type":"journal-article","article-title":"Age-related changes in both circadian and seasonal rhythms of rectal temperature with special reference to senile dementia of Alzheimer type","volume":"32","author":"Touitou","year":"1986","journal-title":"Gerontology"},{"key":"pmeaab057dbib054","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0197-4580(01)00247-0","type":"journal-article","article-title":"Changing complexity in human behavior and physiology through aging and disease","volume":"23","author":"Vaillancourt","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"pmeaab057dbib055","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2016.03.024","type":"journal-article","article-title":"Impaired thermoregulation and beneficial effects of thermoneutrality in the 3\u2009\u2009\u00d7\u2009\u2009Tg-AD model of Alzheimer\u2019s disease","volume":"43","author":"Vandal","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"pmeaab057dbib056","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/978-94-007-0726-9_12","type":"book","article-title":"Current issues in medical thermography","author":"Vardasca","year":"2013"},{"key":"pmeaab057dbib057","article-title":"Facial temperature as a measure of operator state","author":"Veltman","year":"2005","type":"other"},{"key":"pmeaab057dbib058","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/716453","type":"journal-article","article-title":"Circadian rhythm disturbances in patients with Alzheimer\u2019s disease: a review","volume":"2010","author":"Weldemichael","year":"2010","journal-title":"Int. J. Alzheimer\u2019s Dis."}],"container-title":["Physiological Measurement"],"original-title":[],"link":[{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/40\/i=3\/a=034002\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/40\/i=3\/a=034002?key=crossref.f9971beb50e689c1e4b69fd8d51c64f3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/40\/i=3\/a=034002\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/stacks.iop.org\/0967-3334\/40\/i=3\/a=034002?key=crossref.f9971beb50e689c1e4b69fd8d51c64f3","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:23:44Z","timestamp":1772281424000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab057d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,25]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6579\/ab057d","relation":{},"ISSN":["0967-3334","1361-6579"],"issn-type":[{"value":"0967-3334","type":"print"},{"value":"1361-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]},"assertion":[{"value":"Autonomic impairment in Alzheimer\u2019s disease is revealed by complexity analysis of functional thermal imaging signals during cognitive tasks","name":"article_title","label":"Article Title"},{"value":"Physiological Measurement","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2019 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2018-10-04","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-02-08","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-03-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}