{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:21:51Z","timestamp":1740129711394,"version":"3.37.3"},"reference-count":50,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"tdm","delay-in-days":33,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"National Centre for Research and Development, Poland","award":["LIDER\/074\/L-6\/14\/NCBR\/2015"],"award-info":[{"award-number":["LIDER\/074\/L-6\/14\/NCBR\/2015"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective<\/jats:italic>: The purpose of this study was to evaluate whether the complexity of the corneal pulse (CP) signal can be used to differentiate patients with primary open-angle glaucoma (POAG) from healthy subjects. <jats:italic>Approach<\/jats:italic>: The study sample consisted of 28 patients with POAG and a control, age-matched group of 30 subjects. After standard ophthalmic examination, the CP signal from a randomly selected eye of each participant was measured using non-contact ultrasonic micro-displacement measurement technology. After pre-processing, the complexity of the CP signal was estimated using refined composite multiscale fuzzy entropy (RCMFE) up to scale factor 50. The average RCMFE values were computed from three repeated measurements of the CP signals for each participant and each scale factor. <jats:italic>Main results<\/jats:italic>: The complexity of the CP signal in glaucomatous eyes was higher than that observed in healthy ones. Also, RCMFE of the CP signal was found to differentiate (statistically significantly) between the two groups for scales in the range from 26 to 43. For these scales, the one for which the lowest <jats:italic>p<\/jats:italic>-value (<jats:italic>t<\/jats:italic>-test, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) was obtained when comparing RCMFE between the two groups was selected as the optimal scale. Next, a receiver operating characteristic analysis for the optimal scale showed that the proposed approach of calculating the multiscale entropy of the CP signal has some potential to discriminate between patients with POAG and healthy controls (sensitivity, specificity and accuracy of 0.643, 0.700 and 0.672, respectively). <jats:italic>Significance<\/jats:italic>: In conclusion, RCMFE, as a complexity measure, may be considered an auxiliary indicator to support glaucoma diagnostics.<\/jats:p>","DOI":"10.1088\/1361-6579\/ab89c8","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T22:16:18Z","timestamp":1587075378000},"page":"055011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Using the entropy of the corneal pulse signal to distinguish healthy eyes from eyes affected by primary open-angle glaucoma"],"prefix":"10.1088","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-1927","authenticated-orcid":false,"given":"Monika E","family":"Danielewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142 M","family":"Placek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra K","family":"Kici\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"R\u0119kas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"pmeaab89c8bib1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1034\/j.1600-0420.2003.00122.x","article-title":"Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients","volume":"81","author":"Arend","year":"2003","journal-title":"Acta Ophthalmol. Scand."},{"key":"pmeaab89c8bib2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2415-14-30","article-title":"Clinical utility of spectral analysis of intraocular pressure pulse wave","volume":"14","author":"Asejczyk-Widlicka","year":"2014","journal-title":"BMC Ophthalmol."},{"key":"pmeaab89c8bib3","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s11517-017-1647-5","article-title":"Refined multiscale fuzzy entropy based on standard deviation for biomedical signal analysis","volume":"55","author":"Azami","year":"2017","journal-title":"Med. Biol. Eng. Comput."},{"key":"pmeaab89c8bib4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1097\/IJG.0b013e3181ca7c7a","article-title":"Evaluation of prostaglandin analogue effects on corneal keratocyte density using scanning laser confocal microscopy","volume":"19","author":"Bergonzi","year":"2010","journal-title":"J. Glaucoma"},{"key":"pmeaab89c8bib5","doi-asserted-by":"publisher","first-page":"e495\u2013e498","DOI":"10.1111\/aos.12689","article-title":"Effect of topical prostaglandin analogues on corneal hysteresis","volume":"93","author":"Bol\u00edvar","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"pmeaab89c8bib6","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3109\/02713683.2012.700755","article-title":"Spectral analysis of intraocular pressure pulse wave in open angle glaucomas and healthy eyes","volume":"37","author":"Bo\u017ei\u0107","year":"2012","journal-title":"Curr. Eye Res."},{"key":"pmeaab89c8bib7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1088\/1361-6579\/aa513c","article-title":"Heart rate complexity analysis in Brugada syndrome during physical stress testing","volume":"38","author":"Calvo","year":"2017","journal-title":"Physiol. Meas."},{"key":"pmeaab89c8bib8","doi-asserted-by":"publisher","first-page":"s118\u2013s124","DOI":"10.1016\/0039-6257(94)90055-8","article-title":"Differences in the longterm effect of timolol and betaxolol on the pulsatile ocular blood flow","volume":"38","author":"Carenini","year":"1994","journal-title":"Surv. Ophthalmol."},{"key":"pmeaab89c8bib9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1109\/TNSRE.2007.897025","article-title":"Characterization of surface EMG signal based on fuzzy entropy","volume":"15","author":"Chen","year":"2007","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"pmeaab89c8bib10","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3390\/e17031197","article-title":"Generalized multiscale entropy analysis: application to quantifying the complex volatility of human heartbeat time series","volume":"17","author":"Costa","year":"2015","journal-title":"Entropy"},{"key":"pmeaab89c8bib11","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.89.068102","article-title":"Multiscale entropy analysis of complex physiologic time series","volume":"89","author":"Costa","year":"2002","journal-title":"Phys. Rev. Lett."},{"key":"pmeaab89c8bib12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1444-0938.2012.00775.x","article-title":"Phase dependencies between longitudinal corneal apex displacement and cardiovascular signals: Is the ocular pulse influenced by the electrical activity of the heart?","volume":"95","author":"Danielewska","year":"2012","journal-title":"Clin. Exp. Optom."},{"key":"pmeaab89c8bib13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/OPX.0000000000000113","article-title":"Age-related changes in corneal pulsation: ocular dicrotism","volume":"91","author":"Danielewska","year":"2014a","journal-title":"Optom. Vis. Sci."},{"key":"pmeaab89c8bib14","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1007\/s00417-019-04433-9","article-title":"Changes in spectral parameters of corneal pulse following canaloplasty","volume":"257","author":"Danielewska","year":"2019b","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"pmeaab89c8bib15","first-page":"6202","article-title":"Evaluation of spectral changes in corneal pulse signal following canaloplasty","volume":"ARVO 60","author":"Danielewska","year":"2019a","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102814","article-title":"Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism","volume":"9","author":"Danielewska","year":"2014b","journal-title":"PLoS One"},{"key":"pmeaab89c8bib17","first-page":"2022","article-title":"The effect of canaloplasty on changes in corneal pulse parameters: a follow-up study","volume":"ARVO 59","author":"Danielewska","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib18","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1167\/iovs.09-3760","article-title":"Ocular rigidity, ocular pulse amplitude and pulsatile ocular blood flow: the effect of intraocular pressure","volume":"50","author":"Dastiridou","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054207","article-title":"Analysis of pulsatile retinal movements by spectral-domain low-coherence interferometry: influence of age and glaucoma on the pulse wave","volume":"8","author":"Dion","year":"2013","journal-title":"PLoS One"},{"key":"pmeaab89c8bib20","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/eye.2008.47","article-title":"Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls.","volume":"23","author":"Ebneter","year":"2009","journal-title":"Eye"},{"key":"pmeaab89c8bib21","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00417-002-0460-4","article-title":"Spectral content of the intraocular pressure pulse wave: glaucoma patients versus normal subjects","volume":"240","author":"Evans","year":"2002","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"pmeaab89c8bib22","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1136\/bjo.2005.067637","article-title":"Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension","volume":"89","author":"Fuchsj\u00e4ger-Mayrl","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"pmeaab89c8bib23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0197-4580(01)00266-4","article-title":"What is physiologic complexity and how does it change with aging and disease?","volume":"23","author":"Goldberger","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"pmeaab89c8bib24","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1172\/JCI117446","article-title":"Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release","volume":"94","author":"Hartman","year":"1994","journal-title":"J. Clin. Invest."},{"key":"pmeaab89c8bib25","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1167\/iovs.07-1342","article-title":"Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma","volume":"49","author":"Hommer","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1001\/archopht.1971.01000010007002","article-title":"Crest time evaluation of corneal indentation pulse","volume":"86","author":"H\u00f8rven","year":"1971","journal-title":"Arch. Ophthalmol."},{"key":"pmeaab89c8bib27","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/j.1475-1313.2006.00415.x","article-title":"Dynamics in longitudinal eye movements and corneal shape","volume":"26","author":"Iskander","year":"2006","journal-title":"Ophthalmic Physiol. Opt."},{"key":"pmeaab89c8bib28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/sj.eye.6702578","article-title":"Spectral characteristics of longitudinal corneal apex velocities and their relation to the cardiopulmonary system","volume":"21","author":"Kasprzak","year":"2007","journal-title":"Eye"},{"key":"pmeaab89c8bib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4199\/C00024ED1V01Y201012ISP012","article-title":"The ocular circulation","volume":"3","author":"Kiel","year":"2011","journal-title":"Coll. Series Integr. Syst. Physiol.: Molecule Funct."},{"key":"pmeaab89c8bib30","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0002-9394(98)00438-3","article-title":"Irreversible corneal decompensation in patients treated with topical dorzolamide","volume":"127","author":"Konowal","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"pmeaab89c8bib31","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1109\/TBME.2010.2100819","article-title":"Ultrasonic in vivo measurement of ocular surface expansion","volume":"58","author":"Kowalska","year":"2011","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"pmeaab89c8bib32","doi-asserted-by":"publisher","first-page":"53115","DOI":"10.1109\/ACCESS.2019.2911555","article-title":"Variability of cardiac electromechanical delay with application to the noninvasive detection of coronary artery disease","volume":"7","author":"Li","year":"2019","journal-title":"IEEE Access"},{"key":"pmeaab89c8bib33","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.ultras.2011.05.011","article-title":"Ultrasonic system for accurate distance measurement in the air","volume":"51","author":"Licznerski","year":"2011","journal-title":"Ultrasonics"},{"key":"pmeaab89c8bib34","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1001\/jama.1992.03480130122036","article-title":"Loss of \u2018complexity\u2019 and aging: potential applications of fractals and chaos theory to senescence","volume":"267","author":"Lipsitz","year":"1992","journal-title":"J. Am. Med. Assoc."},{"key":"pmeaab89c8bib35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124721","article-title":"Wavelet representation of the corneal pulse for detecting ocular dicrotism","volume":"10","author":"Melcer","year":"2015","journal-title":"PLoS One"},{"key":"pmeaab89c8bib36","doi-asserted-by":"publisher","first-page":"68027","DOI":"10.1109\/ACCESS.2018.2877918","article-title":"Beta iterative synchronization: an algorithm for structural signal averaging","volume":"6","author":"Mirecki","year":"2018","journal-title":"IEEE Access"},{"key":"pmeaab89c8bib37","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1167\/iovs.11-9388","article-title":"Ophthalmic artery doppler waveform changes associated with increased damage in glaucoma patients","volume":"53","author":"Pinto","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.exer.2017.07.003","article-title":"In-vivo corneal pulsation in relation to in-vivo intraocular pressure and corneal biomechanics assessed in-vitro. An animal pilot study","volume":"162","author":"Rogala","year":"2017","journal-title":"Exp. Eye Res."},{"key":"pmeaab89c8bib39","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1117\/12.193292","article-title":"Topical measurement of fundus pulsations","volume":"34","author":"Schmetterer","year":"1995","journal-title":"Opt. Eng."},{"year":"2012","author":"Schmetterer","key":"pmeaab89c8bib40"},{"key":"pmeaab89c8bib41","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.1167\/iovs.13-12930","article-title":"Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma","volume":"54","author":"Shiga","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"pmeaab89c8bib42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1755-3768.1989.tb07083.x","article-title":"Estimation of pulsatile ocular blood flow from intraocular pressure","volume":"67","author":"Silver","year":"1989","journal-title":"Acta Ophthalmolog."},{"key":"pmeaab89c8bib43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149587","article-title":"Electroencephalographic fractal dimension in healthy ageing and Alzheimer\u2019s disease","volume":"11","author":"Smits","year":"2016","journal-title":"PLoS One"},{"key":"pmeaab89c8bib44","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/BF00203321","article-title":"Factors influencing the ocular pulse\u2014the heart rate","volume":"229","author":"Trew","year":"1991","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"pmeaab89c8bib45","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.2147\/DDDT.S50622","article-title":"The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes.","volume":"7","author":"Tsikripis","year":"2013","journal-title":"Drug Des. Dev Therapy"},{"key":"pmeaab89c8bib46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0197-4580(01)00247-0","article-title":"Changing complexity in human behavior and physiology through aging and disease","volume":"23","author":"Vaillancourt","year":"2002a","journal-title":"Neurobiol. Aging"},{"key":"pmeaab89c8bib47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0197-4580(01)00310-4","article-title":"Complexity in aging and disease: response to commentaries","volume":"23","author":"Vaillancourt","year":"2002b","journal-title":"Neurobiol. Aging"},{"key":"pmeaab89c8bib48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155527","article-title":"Changes in corneal biomechanical properties after long-term topical prostaglandin therapy","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"pmeaab89c8bib49","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.physleta.2014.03.034","article-title":"Analysis of complex time series using refined composite multiscale entropy","volume":"378","author":"Wu","year":"2014","journal-title":"Phys. Lett. A"},{"key":"pmeaab89c8bib50","first-page":"1018","article-title":"Noncontact detection of ocular pulse-correlation with carotid stenosis","volume":"16","author":"Zuckerman","year":"1977","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Physiological Measurement"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T02:00:58Z","timestamp":1643594458000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ab89c8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,6,3]]},"published-print":{"date-parts":[[2020,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6579\/ab89c8","relation":{},"ISSN":["0967-3334","1361-6579"],"issn-type":[{"type":"print","value":"0967-3334"},{"type":"electronic","value":"1361-6579"}],"subject":[],"published":{"date-parts":[[2020,5,1]]},"assertion":[{"value":"Using the entropy of the corneal pulse signal to distinguish healthy eyes from eyes affected by primary open-angle glaucoma","name":"article_title","label":"Article Title"},{"value":"Physiological Measurement","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 Institute of Physics and Engineering in Medicine","name":"copyright_information","label":"Copyright Information"},{"value":"2020-02-06","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-04-16","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-06-03","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}