{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:00:53Z","timestamp":1792515653141,"version":"4.5.0"},"reference-count":58,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"tdm","delay-in-days":47,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Cirrhosis is associated with abnormal autonomic function and regulation of cardiac rhythm. Measurement of heart rate variability (HRV) provides an accurate and non-invasive measurement of autonomic function as well as liver disease severity currently calculated using the MELD, UKELD, or Child\u2013Pugh scores. This review assesses the methods employed for the measurement of HRV, and evaluates the alteration of HRV indices in cirrhosis, as well as their value in prognosis.\n                    <jats:italic>Method.<\/jats:italic>\n                    We undertook a systematic review using Medline, Embase and Pubmed databases in July 2020. Data were extracted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias of the included studies was assessed by a modified version of the Newcastle\u2013Ottawa Scale. The descriptive studies were analysed and the standardized mean differences of HRV indices were pooled.\n                    <jats:italic>Results.<\/jats:italic>\n                    Of the 247 studies generated from our search, 14 studies were included. One of the 14 studies was excluded from meta-analysis because it reported only the median of HRV indices. The studies included have a low risk of bias and include 583 patients with cirrhosis and 349 healthy controls. The HRV time and frequency domains were significantly lower in cirrhotic patients. Between-studies heterogeneity was high in most of the pooled studies (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Further, HRV indices predict survival independent of the severity of liver disease as assessed by MELD.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    HRV is decreased in patients with cirrhosis compared with healthy matched controls. HRV correlated with severity of liver disease and independently predicted survival. There was considerable variation in the methods used for HRV analysis, and this impedes interpretation and clinical applicability. Based on the data analysed, the standard deviation of inter-beat intervals (SDNN) and SDNN corrected for basal heart rate (cSDNN) are the most suitable indices for prognosis in patients with cirrhosis.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/abf888","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T23:09:42Z","timestamp":1618528182000},"page":"055003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Heart rate variability in patients with cirrhosis: a systematic review and meta-analysis"],"prefix":"10.1088","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-0295","authenticated-orcid":false,"given":"Tope","family":"Oyelade","sequence":"first","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Canciani","sequence":"additional","affiliation":[{"name":"La Sapienza University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Carbone","sequence":"additional","affiliation":[{"name":"La Sapienza University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-5092","authenticated-orcid":false,"given":"Jaber S","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"University College London"},{"name":"Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Moore","sequence":"additional","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-2022","authenticated-orcid":false,"given":"Ali R","family":"Mani","sequence":"additional","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"pmeaabf888bib41","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/medicina56030116","type":"journal-article","article-title":"Non-alcoholic cirrhosis and heart rate variability: a systematic mini-review","volume":"56","author":"Amaral","year":"2020","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"pmeaabf888bib22","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1007\/s10620-006-9073-9","type":"journal-article","article-title":"The relationship of heart rate variability with severity and prognosis of cirrhosis","volume":"51","author":"Ates","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"pmeaabf888bib23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.dld.2009.05.009","type":"journal-article","article-title":"Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunction","volume":"42","author":"Baratta","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"pmeaabf888bib6","first-page":"510A","type":"book","article-title":"Development of a UK score for patients with end-stage liver disease","author":"Barber","year":"2007"},{"key":"pmeaabf888bib10","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/liv.13621","type":"journal-article","article-title":"The consideration of heart rate complexity as a co-morbidity factor for liver transplantation selection procedures","volume":"38","author":"Bhogal","year":"2018","journal-title":"Liver Int."},{"key":"pmeaabf888bib39","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.dld.2018.09.011","type":"journal-article","article-title":"Which heart rate variability index is an independent predictor of mortality in cirrhosis\u00a0?\u00a0","volume":"51","author":"Bhogal","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"pmeaabf888bib37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fphys.2013.00026","type":"journal-article","article-title":"The LF\/HF ratio does not accurately measure cardiac sympatho-vagal balance","volume":"4","author":"Billman","year":"2013","journal-title":"Front Physiol."},{"key":"pmeaabf888bib19","author":"Borenstein","year":"2011","type":"book"},{"key":"pmeaabf888bib15","doi-asserted-by":"publisher","first-page":"e14452","DOI":"10.14814\/phy2.14452","type":"journal-article","article-title":"Skin temperature variability is an independent predictor of survival in patients with cirrhosis","volume":"8","author":"Bottaro","year":"2020","journal-title":"Physiol. Rep."},{"key":"pmeaabf888bib40","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1111\/liv.13364","type":"journal-article","article-title":"The role of autonomic dysfunction in predicting 1-year mortality after liver transplantation","volume":"37","author":"Chan","year":"2017","journal-title":"Liver Int."},{"key":"pmeaabf888bib44","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.4049\/jimmunol.1600818","type":"journal-article","article-title":"The acute-on-chronic liver failure syndrome, or when the innate immune system goes astray","volume":"197","author":"Cl\u00e0ria","year":"2016","journal-title":"J. Immunol."},{"key":"pmeaabf888bib24","first-page":"25","type":"journal-article","article-title":"Autonomic function in chronic liver disease assessed by heart rate variability study","volume":"20","author":"Coelho","year":"2001","journal-title":"Rev. Port. Cardiol."},{"key":"pmeaabf888bib4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","type":"journal-article","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J. Hepatol."},{"key":"pmeaabf888bib36","type":"book","article-title":"9.2. The standardized mean difference","volume":"vol 5","author":"Deeks","year":"2011"},{"key":"pmeaabf888bib47","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/SHK.0000000000001453","type":"journal-article","article-title":"Neonatal sepsis alters the excitability of regular spiking cells in the nucleus of the solitary tract in rats","volume":"54","author":"Eftekhari","year":"2020","journal-title":"Shock"},{"key":"pmeaabf888bib12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/gastro\/gox013","type":"journal-article","article-title":"Hepatic encephalopathy","volume":"5","author":"Ferenci","year":"2017","journal-title":"Gastroenterol. Rep."},{"key":"pmeaabf888bib11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4254\/wjh.v6.i1.41","type":"journal-article","article-title":"Hepato-cardiac disorders","volume":"6","author":"Fouad","year":"2014","journal-title":"World J. Hepatol."},{"key":"pmeaabf888bib25","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s10286-006-0337-4","type":"journal-article","article-title":"Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis","volume":"16","author":"Frokjaer","year":"2006","journal-title":"Clin. Auton. Res."},{"key":"pmeaabf888bib48","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/SHK.0b013e318240b4be","type":"journal-article","article-title":"Endotoxemia is associated with partial uncoupling of cardiac pacemaker from cholinergic neural control in rats","volume":"37","author":"Gholami","year":"2012","journal-title":"Shock"},{"key":"pmeaabf888bib57","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.3748\/wjg.v22.i25.5728","type":"journal-article","article-title":"Hepatopulmonary syndrome: What we know and what we would like to know","volume":"22","author":"Grilo-Bensusan","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"pmeaabf888bib50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.autneu.2013.02.022","type":"journal-article","article-title":"Effect of endotoxin on heart rate dynamics in rats with cirrhosis","volume":"177","author":"Haddadian","year":"2013","journal-title":"Auton. Neurosci."},{"key":"pmeaabf888bib49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejphar.2011.10.013","type":"journal-article","article-title":"Interleukin-6 impairs chronotropic responsiveness to cholinergic stimulation and decreases heart rate variability in mice","volume":"673","author":"Hajiasgharzadeh","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"pmeaabf888bib20","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","type":"journal-article","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Brit. Med. J."},{"key":"pmeaabf888bib21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1249\/MSS.0b013e31818cb278","type":"journal-article","article-title":"Progressive statistics for studies in sports medicine and exercise science","volume":"41","author":"Hopkins","year":"2009","journal-title":"Med. Sci. Sports Exercise"},{"key":"pmeaabf888bib26","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1046\/j.1440-1746.2003.03044.x","type":"journal-article","article-title":"Autonomic nervous dysfunction in patients with liver cirrhosis using 123I-metaiodobenzylguanidine myocardial scintigraphy and spectrum analysis of heart-rate variability","volume":"18","author":"Iga","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"pmeaabf888bib38","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/apt.15365","type":"journal-article","article-title":"Significant reduction in heart rate variability is a feature of acute decompensation of cirrhosis and predicts 90-day mortality","volume":"50","author":"Jansen","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"pmeaabf888bib52","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.3748\/wjg.v10.i20.3039","type":"journal-article","article-title":"Autonomic and sensory nerve dysfunction in primary biliary cirrhosis","volume":"10","author":"Keresztes","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"pmeaabf888bib27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1471-230X-13-18","type":"journal-article","article-title":"Physiologic and laboratory correlates of depression, anxiety, and poor sleep in liver cirrhosis","volume":"13","author":"Ko","year":"2013","journal-title":"BMC Gastroenterol."},{"key":"pmeaabf888bib5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.7861\/clinmed.2020-0631","type":"journal-article","article-title":"Acute-on-chronic liver failure","volume":"20","author":"Kumar","year":"2020","journal-title":"Clin. Med."},{"key":"pmeaabf888bib46","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1111\/liv.14057","type":"journal-article","article-title":"Systemic inflammation in hepatorenal syndrome - a target for novel treatment strategies?","volume":"39","author":"Lange","year":"2019","journal-title":"Liver Int."},{"key":"pmeaabf888bib42","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1093\/eurheartj\/ehm018","type":"journal-article","article-title":"Association between cardiac autonomic dysfunction and inflammation in type 1 diabetic patients: effect of beta-blockade","volume":"28","author":"Lanza","year":"2007","journal-title":"Eur. Heart J."},{"key":"pmeaabf888bib43","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1016\/j.amjcard.2006.01.029","type":"journal-article","article-title":"Relation of heart rate variability to serum levels of C-reactive protein in patients with unstable angina pectoris","volume":"97","author":"Lanza","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"pmeaabf888bib28","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1159\/000201505","type":"journal-article","article-title":"Autonomic regulation of heart rate and QT interval in nonalcoholic cirrhosis with ascites","volume":"58","author":"Lazzeri","year":"1997","journal-title":"Digestion"},{"key":"pmeaabf888bib1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0140-6736(06)67924-5","type":"journal-article","article-title":"Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data","volume":"367","author":"Leon","year":"2006","journal-title":"Lancet"},{"key":"pmeaabf888bib17","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1177\/0962280216669183","type":"journal-article","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat. Methods Med. Res."},{"key":"pmeaabf888bib13","doi-asserted-by":"publisher","first-page":"G330","DOI":"10.1152\/ajpgi.90488.2008","type":"journal-article","article-title":"Decreased heart rate variability in patients with cirrhosis relates to the presence and degree of hepatic encephalopathy","volume":"296","author":"Mani","year":"2009","journal-title":"Am. J. Physiol.: Gastroint. Liver Physiol."},{"key":"pmeaabf888bib29","first-page":"251","type":"journal-article","article-title":"Autonomic dysfunction in alcoholic cirrhosis and its relation to sudden cardiac death risk predictors","volume":"28","author":"Milovanovic","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"pmeaabf888bib30","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1046\/j.1440-1746.2001.02493.x","type":"journal-article","article-title":"Relationship among gastric motility, autonomic activity, and portal hemodynamics in patients with liver cirrhosis","volume":"16","author":"Miyajima","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"pmeaabf888bib16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","type":"journal-article","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"pmeaabf888bib31","doi-asserted-by":"publisher","first-page":"G1228","DOI":"10.1152\/ajpgi.00303.2012","type":"journal-article","article-title":"Cardiac sympathetic imaging with mIBG in cirrhosis and portal hypertension: relation to autonomic and cardiac function","volume":"303","author":"Moller","year":"2012","journal-title":"Am. J. Physiol.: Gastroint. Liver Physiol."},{"key":"pmeaabf888bib56","doi-asserted-by":"publisher","first-page":"H2966","DOI":"10.1152\/ajpheart.01227.2006","type":"journal-article","article-title":"Reduced baroreflex sensitivity in alcoholic cirrhosis: relations to hemodynamics and humoral systems","volume":"292","author":"M\u00f8ller","year":"2007","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"pmeaabf888bib45","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/liv.13568","type":"journal-article","article-title":"Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality","volume":"38","author":"M\u00fccke","year":"2018","journal-title":"Liver Int."},{"key":"pmeaabf888bib51","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s11894-013-0362-0","type":"journal-article","article-title":"Useful tests for hepatic encephalopathy in clinical practice","volume":"16","author":"Nabi","year":"2014","journal-title":"Current Gastroenterol. Rep."},{"key":"pmeaabf888bib32","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1097\/MCG.0b013e31818de34c","type":"journal-article","article-title":"Investigation of autonomic function and orocecal transit time in patients with nonalcoholic cirrhosis and the potential influence of these factors on disease outcome","volume":"43","author":"Nagasako","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"key":"pmeaabf888bib33","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1109\/EHB.2015.7391594","type":"journal-article","article-title":"Contribution of the heart rate variability parameters in evaluation of liver cirrhosis severity and associated autonomic dysfunction","volume":"31","author":"Negru","year":"2015","journal-title":"Acta Med. Mediterranea"},{"key":"pmeaabf888bib53","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/j.1478-3231.2009.02075.x","type":"journal-article","article-title":"Chronic hepatitis C virus infection associated with autonomic dysfunction","volume":"29","author":"Osztovits","year":"2009","journal-title":"Liver Int."},{"key":"pmeaabf888bib55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.602456","type":"journal-article","article-title":"Heart rate turbulence predicts survival independently from severity of liver dysfunction in patients with cirrhosis","volume":"11","author":"Oyelade","year":"2020","journal-title":"Front Physiol."},{"key":"pmeaabf888bib2","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.3390\/nu12123860","type":"journal-article","article-title":"Nutritional approaches for the management of nonalcoholic fatty liver disease: an evidence-based review","volume":"12","author":"Parra-Vargas","year":"2020","journal-title":"Nutrients"},{"key":"pmeaabf888bib7","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s11517-006-0119-0","type":"journal-article","article-title":"Heart rate variability: a review","volume":"44","author":"Rajendra Acharya","year":"2006","journal-title":"Med. Biol. Eng. Comput."},{"key":"pmeaabf888bib14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3389\/fphys.2019.00116","type":"journal-article","article-title":"The application of the extended Poincare plot in the analysis of physiological variabilities","volume":"10","author":"Satti","year":"2019","journal-title":"Front. Physiol."},{"key":"pmeaabf888bib3","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","type":"journal-article","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"key":"pmeaabf888bib35","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","type":"journal-article","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front. Public Health"},{"key":"pmeaabf888bib34","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3389\/fpsyg.2014.01040","type":"journal-article","article-title":"A healthy heart is not a metronome: an integrative review of the heart\u2019s anatomy and heart rate variability","volume":"5","author":"Shaffer","year":"2014","journal-title":"Front. Psychol."},{"key":"pmeaabf888bib18","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/jrsm.1429","type":"journal-article","article-title":"Optimally estimating the sample standard deviation from the five-number summary","volume":"11","author":"Shi","year":"2020","journal-title":"Res. Synth. Methods"},{"key":"pmeaabf888bib54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072854","type":"journal-article","article-title":"Quantifying memory in complex physiological time-series","volume":"8","author":"Shirazi","year":"2013","journal-title":"PLoS One"},{"key":"pmeaabf888bib8","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/01.CIR.90.2.878","type":"journal-article","article-title":"Reduced heart rate variability and mortality risk in an elderly cohort","volume":"90","author":"Tsuji","year":"1994","journal-title":"The Framingham Heart Study. Circulation"},{"key":"pmeaabf888bib9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1590\/S0102-76382009000200018","type":"journal-article","article-title":"Basic notions of heart rate variability and its clinical applicability","volume":"24","author":"Vanderlei","year":"2009","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"pmeaabf888bib58","doi-asserted-by":"publisher","DOI":"10.1063\/1.3133128","type":"journal-article","article-title":"Is the normal heart rate \u2018chaotic\u2019 due to respiration?","volume":"19","author":"Wessel","year":"2009","journal-title":"Chaos"}],"container-title":["Physiological Measurement"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:00:08Z","timestamp":1778778008000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/abf888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,6,17]]},"published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6579\/abf888","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.20.21249506","asserted-by":"object"}]},"ISSN":["0967-3334","1361-6579"],"issn-type":[{"value":"0967-3334","type":"print"},{"value":"1361-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"Heart rate variability in patients with cirrhosis: a systematic review and meta-analysis","name":"article_title","label":"Article Title"},{"value":"Physiological Measurement","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2021 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2021-01-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-04-15","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-06-17","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}