{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:27:40Z","timestamp":1788049660235,"version":"build-2784847793"},"reference-count":27,"publisher":"IOP Publishing","issue":"7","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":23,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"QUEX Institute"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    To quantify the agreement between left and right middle cerebral artery blood velocity (MCAv) responses to incremental and constant work-rate exercise in adults.\n                    <jats:italic>Approach<\/jats:italic>\n                    Seventeen healthy adults (23.8 \u00b1 2.4 years, 9 females) completed a ramp incremental test to exhaustion on a cycle ergometer, three 6-minute transitions at a moderate-intensity, and three at a heavy-intensity, all on separate days. Bilateral MCAv was measured throughout using transcranial Doppler ultrasonography, with left and right MCAv data analysed separately. Data were analysed at baseline, gas exchange threshold, respiratory compensation point and exhaustion during ramp incremental exercise. MCAv responses to constant work-rate exercise were analysed using a mono-exponential model, to determine time- and amplitude-based kinetic response parameters.\n                    <jats:italic>Main Results<\/jats:italic>\n                    Left and right MCAv responses to incremental and constant work-rate exercise were significantly, strongly and positively correlated (\n                    <jats:italic>r<\/jats:italic>\n                    \u2265 0.61,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Coefficient of variation (left versus right) ranged from 7.3%\u201320.7%, 6.4%\u201326.2% and 5.9%\u201322.5% for ramp, moderate and heavy-intensity exercise, respectively. The relative change in MCAv from baseline was higher in the right compared to left MCAv during ramp, moderate and heavy-intensity exercise (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), but the effect sizes were small (\n                    <jats:italic>d<\/jats:italic>\n                    \u2264 0.4). Small mean left\u2013right differences were present during ramp incremental exercise at all time-points (&lt;6 cm s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; &lt;4%), and for all kinetic parameters during moderate and heavy-intensity exercise (&lt;3 cm s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , &lt;3%, &lt;4 s).\n                    <jats:italic>Significance<\/jats:italic>\n                    These findings demonstrate similarities between left and right MCAv responses to incremental and constant-work rate exercise in adults on a group-level, but also highlight individual variation in the agreement between left and right MCAv exercise responses.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/ace49d","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T18:44:37Z","timestamp":1688582677000},"page":"074001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Agreement between left and right middle cerebral artery blood velocity responses to incremental and constant work-rate exercise in healthy males and females"],"prefix":"10.1088","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-6512","authenticated-orcid":false,"given":"Max E","family":"Weston","sequence":"first","affiliation":[{"name":"University of Exeter"},{"name":"The University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-5417","authenticated-orcid":false,"given":"Alan R","family":"Barker","sequence":"additional","affiliation":[{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-7682","authenticated-orcid":false,"given":"Owen W","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-3596","authenticated-orcid":false,"given":"Jeff S","family":"Coombes","sequence":"additional","affiliation":[{"name":"The University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-2780","authenticated-orcid":false,"given":"Tom G","family":"Bailey","sequence":"additional","affiliation":[{"name":"The University of Queensland"},{"name":"The University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-8562","authenticated-orcid":false,"given":"Bert","family":"Bond","sequence":"additional","affiliation":[{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"pmeaace49dbib1","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1152\/japplphysiol.00854.2014","type":"journal-article","article-title":"Transcranial Doppler ultrasound: valid, invalid, or both?","volume":"117","author":"Ainslie","year":"2014","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib2","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1152\/jappl.1986.60.6.2020","type":"journal-article","article-title":"A new method for detecting anaerobic threshold by gas exchange","volume":"60","author":"Beaver","year":"1986","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib3","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/japplphysiol.00995.2016","type":"journal-article","article-title":"Dynamics of middle cerebral artery blood flow velocity during moderate-intensity exercise","volume":"122","author":"Billinger","year":"2017","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib4","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14367","type":"journal-article","article-title":"Dynamic cerebral autoregulation across the cardiac cycle during 8 h of recovery from acute exercise","volume":"8","author":"Burma","year":"2020","journal-title":"Physiol. Rep."},{"key":"pmeaace49dbib5","author":"Cohen","year":"1977","type":"book"},{"key":"pmeaace49dbib6","doi-asserted-by":"publisher","first-page":"H1195","DOI":"10.1152\/ajpheart.00034.2017","type":"journal-article","article-title":"Anterior cerebral blood velocity and end-tidal CO2 responses to exercise differ in children and adults","volume":"312","author":"Ellis","year":"2017","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"pmeaace49dbib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5603\/FM.a2021.0134","type":"journal-article","article-title":"Circle of Willis: anatomical variations of configuration. a magnetic resonance angiography study","volume":"82","author":"Enyedi","year":"2021","journal-title":"Folia Morphol (Warsz)"},{"key":"pmeaace49dbib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2165\/00007256-200030010-00001","type":"journal-article","article-title":"Measures of reliability in sports medicine and science","volume":"30","author":"Hopkins","year":"2000","journal-title":"Sports Med."},{"key":"pmeaace49dbib9","first-page":"2423","type":"journal-article","article-title":"A comprehensive study of the anatomical variations of the circle of willis in adult human brains","volume":"7","author":"Iqbal","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"pmeaace49dbib10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1447-073X.2007.00216.x","type":"journal-article","article-title":"Variations in the configuration of the circle of Willis","volume":"83","author":"Kapoor","year":"2008","journal-title":"Anat. Sci. Int."},{"key":"pmeaace49dbib11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1177\/0271678X16631149","type":"journal-article","article-title":"Measurement of cerebral blood flow using phase contrast magnetic resonance imaging and duplex ultrasonography","volume":"37","author":"Khan","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"pmeaace49dbib12","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1249\/MSS.0000000000001924","type":"journal-article","article-title":"Cerebral blood flow during interval and continuous exercise in young and old men","volume":"51","author":"Klein","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"pmeaace49dbib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1113\/EP090031","type":"journal-article","article-title":"The within- and between-day reliability of cerebrovascular reactivity using traditional and novel analytical approaches","volume":"107","author":"Koep","year":"2021","journal-title":"Exp. Physiol."},{"key":"pmeaace49dbib14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1055\/s-0031-1273754","type":"journal-article","article-title":"A \u2018new\u2019 method to normalise exercise intensity","volume":"32","author":"Lansley","year":"2011","journal-title":"Int. J. Sports Med."},{"key":"pmeaace49dbib15","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/01.STR.17.6.1156","type":"journal-article","article-title":"Regional cerebral blood flow changes associated with ethanol intoxication","volume":"17","author":"Mathew","year":"1986","journal-title":"Stroke"},{"key":"pmeaace49dbib16","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1152\/japplphysiol.00573.2009","type":"journal-article","article-title":"Cerebral blood flow during exercise: mechanisms of regulation","volume":"107","author":"Ogoh","year":"2009","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/jon200010133","type":"journal-article","article-title":"Caffeine can affect velocity in the middle cerebral artery during hyperventilation, hypoventilation, and thinking: a transcranial Doppler study","volume":"10","author":"Perod","year":"2000","journal-title":"J. Neuroimaging"},{"key":"pmeaace49dbib18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1152\/japplphysiol.01063.2016","type":"journal-article","article-title":"Measurement of the maximum oxygen uptake Vo2max: Vo2peak is no longer acceptable","volume":"122","author":"Poole","year":"2017","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/01.STR.25.1.17","type":"journal-article","article-title":"Estimation of cerebral blood flow through color duplex sonography of the carotid and vertebral arteries in healthy adults","volume":"25","author":"Schoning","year":"1994","journal-title":"Stroke"},{"key":"pmeaace49dbib20","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1113\/EP086249","type":"journal-article","article-title":"Regulation of cerebral blood flow and metabolism during exercise","volume":"102","author":"Smith","year":"2017","journal-title":"Exp. Physiol."},{"key":"pmeaace49dbib21","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1152\/japplphysiol.00348.2020","type":"journal-article","article-title":"Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics","volume":"129","author":"Thomas","year":"2020","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib22","doi-asserted-by":"publisher","first-page":"H492","DOI":"10.1152\/ajpheart.00129.2018","type":"journal-article","article-title":"Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise","volume":"315","author":"Ward","year":"2018","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"pmeaace49dbib23","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1152\/japplphysiol.00182.2021","type":"journal-article","article-title":"Differences in cerebrovascular regulation and ventilatory responses during ramp incremental cycling in children, adolescents, and adults","volume":"131","author":"Weston","year":"2021","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1152\/japplphysiol.00862.2021","type":"journal-article","article-title":"The effect of exercise intensity and cardiorespiratory fitness on the kinetic response of middle cerebral artery blood velocity during exercise in healthy adults","volume":"133","author":"Weston","year":"2022a","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/japplphysiol.00772.2021","type":"journal-article","article-title":"The acute effect of exercise intensity on peripheral and cerebral vascular function in healthy adults","volume":"133","author":"Weston","year":"2022b","journal-title":"J. Appl. Physiol. (1985)"},{"key":"pmeaace49dbib26","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1152\/jappl.1982.52.6.1506","type":"journal-article","article-title":"Parameters of ventilatory and gas exchange dynamics during exercise","volume":"52","author":"Whipp","year":"1982","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"pmeaace49dbib27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.resp.2019.01.013","type":"journal-article","article-title":"Exercise intensity and middle cerebral artery dynamics in humans","volume":"262","author":"Witte","year":"2019","journal-title":"Respir. Physiol. Neurobiol."}],"container-title":["Physiological Measurement"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:37:44Z","timestamp":1778776664000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ace49d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7,24]]},"published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1361-6579\/ace49d","relation":{},"ISSN":["0967-3334","1361-6579"],"issn-type":[{"value":"0967-3334","type":"print"},{"value":"1361-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"Agreement between left and right middle cerebral artery blood velocity responses to incremental and constant work-rate exercise in healthy males and females","name":"article_title","label":"Article Title"},{"value":"Physiological Measurement","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2023-03-14","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-07-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-07-24","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}