{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:22:41Z","timestamp":1740129761820,"version":"3.37.3"},"reference-count":28,"publisher":"IOP Publishing","issue":"11","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"tdm","delay-in-days":13,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["179905"],"award-info":[{"award-number":["179905"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss Government","award":["Swiss Government Excellence Scholarship"],"award-info":[{"award-number":["Swiss Government Excellence Scholarship"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective.<\/jats:italic> Sulfur hexafluoride (SF<jats:sub>6<\/jats:sub>) multiple-breath washout (MBW) assesses ventilation inhomogeneity, as an early marker of obstructive respiratory diseases. Primary outcomes are customarily washout-derived, and it is unclear whether the preceding SF<jats:sub>6<\/jats:sub>-washin can provide similar estimates. We aimed to assess comparability of primary SF<jats:sub>6<\/jats:sub>-MBW outcomes between washin and washout phases of infant SF<jats:sub>6<\/jats:sub>-MBW data measured with the WBreath (ndd Medizintechnik AG, Zurich, Switzerland) and Spiroware (Eco Medics AG, Duernten, Switzerland) MBW-setups, respectively. <jats:italic>Approach.<\/jats:italic> We assessed mean relative differences in lung clearance index (LCI) and functional residual capacity (FRC) between the washin and washout of existing SF<jats:sub>6<\/jats:sub>-MBW data from healthy infants and infants with cystic fibrosis (CF). We assessed whether these differences exceeded the mean relative within-test between-trial differences of washout-derived outcomes, which can be attributed to natural variability. We also explored non-physiological factors using a pediatric lung simulator. <jats:italic>Main results.<\/jats:italic> LCI and FRC from washin and washout were not comparable, for both setups. The mean difference (SD) in LCI between washin and washout was 2.3(10.8)% for WBreath and \u22129.7(8.0)% for Spiroware, while in FRC it was \u22124.7(8.4)% for WBreath and \u22122.3(9.7)% for Spiroware. These differences exceeded the within-test between-trial differences in washout-derived outcomes. Outcomes from washin and washout were also not comparable in a pediatric lung simulator. <jats:italic>Significance.<\/jats:italic> Outcomes of the washin and washout were not comparable due to an interplay of physiological and non-physiological factors, and cannot be used interchangeably.<\/jats:p>","DOI":"10.1088\/1361-6579\/ad8da4","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T22:56:53Z","timestamp":1730415413000},"page":"115003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulfur hexafluoride multiple breath washin and washout outcomes in infants are not interchangeable"],"prefix":"10.1088","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-9725","authenticated-orcid":true,"given":"Anne-Christianne","family":"Kentgens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Wyler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Alexander","family":"Oestreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Latzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Yammine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"pmeaad8da4bib1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.clinbiomech.2017.11.002","article-title":"An innovative lung model for multiple breath washout testing in health and disease","volume":"66","author":"Anagnostopoulou","year":"2019","journal-title":"Clin. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-04-11","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-10-31","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-11-14","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}