{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:54:52Z","timestamp":1775840092527,"version":"3.50.1"},"reference-count":26,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"AusTechnion and the Ingham Institute for Applied Medical Research"},{"name":"Estate of Zofia (Sophie) Fridman and funding from the Israel Innovation Authority"},{"name":"Ministry of Innovation and Technology with support from the National Research Development and Innovation Fund under the TKP2021","award":["TKP2021-NVA-27"],"award-info":[{"award-number":["TKP2021-NVA-27"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2026,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Large vessel occlusion (LVO) stroke presents a major challenge in clinical practice due to the potential for poor outcomes with delayed treatment. Treatment for LVO involves highly specialized care, in particular endovascular thrombectomy, and is available only at certain hospitals. Therefore, prehospital identification of LVO by emergency ambulance services, can be critical for triaging LVO stroke patients directly to a hospital with access to endovascular therapy. Clinical scores exist to help distinguish LVO from less severe strokes, but they are based on a series of examinations that can be time-consuming and may be impractical for patients with dementia or those who cannot follow commands due to their stroke. There is a need for a fast and reliable method to aid in the early identification of LVO. In this study, our objective was to assess the feasibility of using 30 s photoplethysmography (PPG) recording to assist in recognizing LVO stroke.\n                    <jats:italic>Approach.<\/jats:italic>\n                    A total of 88 patients, including 25 with LVO, 27 with stroke mimic (SM), and 36 non-LVO stroke patients (NL), were recorded at the Liverpool Hospital emergency department in Sydney, Australia. Demographics (age, sex), as well as morphological features and beating rate variability measures, were extracted from the PPG. A binary classification approach was employed to differentiate between LVO stroke and NL + SM (NL.SM). A 2:1 train-test split was stratified and repeated randomly across 100 iterations.\n                    <jats:italic>Main results.<\/jats:italic>\n                    The best model achieved a median test set area under the receiver operating characteristic curve of 0.77 (0.71\u20130.82).\n                    <jats:italic>Significance.<\/jats:italic>\n                    Our study demonstrates the potential of utilizing a 30 s PPG recording for identifying LVO stroke.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/ae2562","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T22:55:15Z","timestamp":1764284115000},"page":"015007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Machine learning for triage of strokes with large vessel occlusion using photoplethysmography biomarkers"],"prefix":"10.1088","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-5940","authenticated-orcid":true,"given":"M\u00e1rton \u00c1","family":"Goda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-393X","authenticated-orcid":false,"given":"Helen","family":"Badge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0555-620X","authenticated-orcid":false,"given":"Jasmeen","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-1201","authenticated-orcid":false,"given":"Yosef","family":"Solewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-6523","authenticated-orcid":false,"given":"Moran","family":"Davoodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumbidzai","family":"Teramayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-6644","authenticated-orcid":true,"given":"Dennis","family":"Cordato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-9846","authenticated-orcid":false,"given":"Longting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-5614","authenticated-orcid":false,"given":"Lauren","family":"Christie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-9622","authenticated-orcid":false,"given":"Christopher","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagan","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8874-2487","authenticated-orcid":false,"given":"Mark","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-7034","authenticated-orcid":true,"given":"Joachim A","family":"Behar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"pmeaae2562bib1","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1152\/ajpheart.00705.2022","type":"journal-article","article-title":"Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet","volume":"325","author":"Alastruey","year":"2023","journal-title":"Am. 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Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2025-07-14","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-11-27","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-19","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}