{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:41:40Z","timestamp":1772102500935,"version":"3.50.1"},"reference-count":20,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"crossref","award":["2025GH-YBXM-007"],"award-info":[{"award-number":["2025GH-YBXM-007"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62271251"],"award-info":[{"award-number":["62271251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Graduate Research and Practice Innovation Program of Nanjing University of Aeronautics and Astronautics","award":["xcxjh20230505"],"award-info":[{"award-number":["xcxjh20230505"]}]},{"name":"the Science and Technology Project of Guangzhou","award":["2023B03J1353"],"award-info":[{"award-number":["2023B03J1353"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2026,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    The objective of this study was to assess the feasibility and accuracy of computed tomography (CT)-guided electrical impedance tomography (CT-guided EIT) in the quantitative detection of the spatial distribution and location of pneumothorax, hemothorax, and hemopneumothorax lesions and effective ventilation regions in pig models.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Five Bama miniature pigs were used to establish models of pneumothorax, hemothorax, and hemopneumothorax by incrementally injecting air or Ringer\u2019s solution in 100 ml steps up to a total volume of 500 ml into the right pleural cavity. Synchronous EIT data and CT images were acquired at each experimental stage. EIT images were reconstructed using the GREIT algorithm with anatomical constraints derived from CT-based lung contours. Mean total boundary voltage (mTBV), pneumothorax pixel area (PPA), hemothorax pixel area (HPA), center of ventilation (CoV), Dice similarity coefficient (Dice), and centroid distance (\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>c<\/jats:sub>\n                    ) were used for quantitative assessment. PPA, HPA, and CoV are statistically compared between EIT and CT using Spearman correlation and Bland\u2013Altman agreement analysis.\n                    <jats:italic>Main results.<\/jats:italic>\n                    mTBV showed a strong linear correlation with injected air volume (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.968\u20130.994) and fluid volume (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.712\u20130.994). In pneumothorax models, Dice = 0.828\u20130.884 and\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>c<\/jats:sub>\n                    = 2.80\u20133.33. In hemothorax models, Dice = 0.850\u20130.874 and\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>c<\/jats:sub>\n                    = 2.64\u20133.34. PPA, HPA, and CoV derived from CT-guided EIT images correlated significantly with CT findings (Spearman\n                    <jats:italic>r<\/jats:italic>\n                    = 0.63\u20130.92,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Ventilation distribution patterns in EIT were consistent with CT, with dorsal shifts during pneumothorax and ventral shifts during hemothorax. Bland\u2013Altman plots showed good agreement between EIT and CT measurements.\n                    <jats:italic>Significance.<\/jats:italic>\n                    This study demonstrates the feasibility of CT-guided EIT for dynamic monitoring and quantitative evaluation of pneumothorax, hemothorax, and hemopneumothorax in pig models. Its noninvasive, radiation-free, and bedside monitoring nature makes it a promising tool for detecting pulmonary pathological accumulation during mechanical ventilation and postoperative care.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/ae466a","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:55:06Z","timestamp":1772099706000},"page":"025016","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive detection of pulmonary pathological accumulation with CT-guided electrical impedance tomography: a feasibility study"],"prefix":"10.1088","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6203-3999","authenticated-orcid":false,"given":"Zhiwei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-2101","authenticated-orcid":false,"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-0489","authenticated-orcid":false,"given":"Chen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-1712","authenticated-orcid":true,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-0512","authenticated-orcid":true,"given":"Jiafeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"pmeaae466abib1","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1088\/0967-3334\/30\/6\/S03","type":"journal-article","article-title":"GREIT: a unified approach to 2D linear EIT reconstruction of lung images","volume":"30","author":"Adler","year":"2009","journal-title":"Physiol. Meas."},{"key":"pmeaae466abib2","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1152\/jappl.1997.83.5.1762","type":"journal-article","article-title":"Monitoring changes in lung air and liquid volumes with electrical impedance tomography","volume":"83","author":"Adler","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"pmeaae466abib3","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00134-011-2421-z","type":"journal-article","article-title":"Electrical impedance tomography can rapidly detect small pneumothoraces in surfactant-depleted piglets","volume":"38","author":"Bhatia","year":"2012","journal-title":"Intensive Care Med."},{"key":"pmeaae466abib4","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1097\/CCM.0b013e31816a0380","type":"journal-article","article-title":"Real-time detection of pneumothorax using electrical impedance tomography*","volume":"36","author":"Costa","year":"2008","journal-title":"Crit. Care Med."},{"key":"pmeaae466abib5","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ad7f1f","type":"journal-article","article-title":"Physiological definition for region of interest selection in electrical impedance tomography data: description and validation of a novel method","volume":"45","author":"Francovich","year":"2024","journal-title":"Physiol. Meas."},{"key":"pmeaae466abib6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25405","type":"journal-article","article-title":"Monitoring of spontaneous pneumothorax using electrical impedance tomography: a case report","volume":"10","author":"Gao","year":"2024","journal-title":"Heliyon"},{"key":"pmeaae466abib7","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.1088\/0967-3334\/27\/5\/S16","type":"journal-article","article-title":"Imaging pathologic pulmonary air and fluid accumulation by functional and absolute EIT","volume":"27","author":"Hahn","year":"2006","journal-title":"Physiol. 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Med."},{"key":"pmeaae466abib11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.advms.2021.07.010","type":"journal-article","article-title":"Electrical impedance tomography as a tool for monitoring mechanical ventilation. An introduction to the technique","volume":"66","author":"Maciejewski","year":"2021","journal-title":"Adv. Med. Sci."},{"key":"pmeaae466abib12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.annemergmed.2018.08.423","type":"journal-article","article-title":"Pneumothorax and hemothorax in the era of frequent chest computed tomography for the evaluation of adult patients with blunt trauma","volume":"73","author":"Rodriguez","year":"2019","journal-title":"Ann. Emergency Med."},{"key":"pmeaae466abib13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1186\/s13054-024-05173-x","type":"journal-article","article-title":"Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions","volume":"28","author":"Scaramuzzo","year":"2024","journal-title":"Crit. Care"},{"key":"pmeaae466abib14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jemermed.2021.07.006","type":"journal-article","article-title":"Traumatic pneumothorax: a review of current diagnostic practices and evolving management","volume":"61","author":"Tran","year":"2021","journal-title":"J. Emergency Med."},{"key":"pmeaae466abib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejmp.2020.08.020","type":"journal-article","article-title":"Radiation dose monitoring in computed tomography: status, options and limitations","volume":"79","author":"Tsalafoutas","year":"2020","journal-title":"Phys. Med."},{"key":"pmeaae466abib16","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.jpedsurg.2020.09.003","type":"journal-article","article-title":"Chest x-ray vs. computed tomography of the chest in pediatr. blunt trauma","volume":"56","author":"Ugalde","year":"2021","journal-title":"J. Pediatric Surg."},{"key":"pmeaae466abib17","doi-asserted-by":"publisher","first-page":"A456","DOI":"10.1186\/2197-425X-3-S1-A456","type":"journal-article","article-title":"Assessment of silent spaces at different PEEP levels by electrical impedance tomography in severe COPD","volume":"3","author":"Waldmann","year":"2015","journal-title":"Intensive Care Med. Exp."},{"key":"pmeaae466abib18","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1357160","type":"journal-article","article-title":"Real-time detection of hemothorax and monitoring its progression in a piglet model by electrical impedance tomography: a feasibility study","volume":"2020","author":"Yang","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"pmeaae466abib19","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10877-022-00935-w","type":"journal-article","article-title":"Bedside electrical impedance tomography in early diagnosis of pneumothorax in mechanically ventilated ICU patients\u2014a single-center retrospective cohort study","volume":"37","author":"Yang","year":"2023","journal-title":"J. Clin. Monit. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-06-04","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-02-16","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-02-26","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}