{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:26:59Z","timestamp":1787038019385,"version":"build-2736575974"},"reference-count":27,"publisher":"IOP Publishing","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Shanghai Municipal Science and Technology Committee","award":["22Y11904200"],"award-info":[{"award-number":["22Y11904200"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Physiol. Meas."],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Low tidal volume, limited driving pressure and positive end expiratory pressure (PEEP) are well-accepted lung-protected ventilation strategies. The study aimed to compare driving pressure targeted strategy (PTS) and low tidal volume + PEEP strategy (VPS) in term of ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Patients undergoing anesthesia induction were randomly assign to either PTS or VPS groups. An inspiration pressure of 15 cm H\n                    <jats:sub>2<\/jats:sub>\n                    O and zero PEEP was used in PTS group. A tidal volume of 8 ml kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    predicted body weight and a PEEP of 5 cm H\n                    <jats:sub>2<\/jats:sub>\n                    O was used in VPS group. The regional lung ventilation was monitored by electrical impedance tomography (EIT). Expiratory tidal volume (\n                    <jats:italic>TV<\/jats:italic>\n                    e), driving pressure, hemodynamics and PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    , and EIT-derived ventilation homogeneity (global inhomogeneity index,\n                    <jats:italic>GI<\/jats:italic>\n                    ), the ratio of left\/right lung ventilation distribution were calculated.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Finally, 30 patients with PTS and 25 with VPS were analyzed. Compared with spontaneous ventilation, mechanical ventilation via mask caused significant changes in the\n                    <jats:italic>GI<\/jats:italic>\n                    (0.40 \u00b1 0.04 vs 0.48 \u00b1 0.08,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). When compared with PTS, VPS was associated with improved\n                    <jats:italic>GI<\/jats:italic>\n                    (0.52 \u00b1 0.09 vs 0.42 \u00b1 0.03, PTS vs VPS,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001, power value 0.955), lower\n                    <jats:italic>TV<\/jats:italic>\n                    e (625.3 \u00b1 192.7 vs 429.1 \u00b1 48.8 ml,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), lower driving pressure (15 \u00b1 0 vs 10.5 \u00b1 1.5 cm H\n                    <jats:sub>2<\/jats:sub>\n                    O,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), and slightly higher but not statistically different PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    (370.7 \u00b1 90.1 vs 391.1 \u00b1 48.9 mm Hg),\n                    <jats:italic>P<\/jats:italic>\n                    = 0.380).\n                    <jats:italic>Significance<\/jats:italic>\n                    . Mask mechanical ventilation with VPS may improve the lung ventilation inhomogeneity during anesthetic induction when compared with PTS.\n                  <\/jats:p>","DOI":"10.1088\/1361-6579\/ae8d7c","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T22:52:37Z","timestamp":1784587957000},"page":"085021","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized trial comparing two ventilation strategies"],"prefix":"10.1088","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-7194","authenticated-orcid":true,"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Gao","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxia","family":"Pan","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Pan","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-2207","authenticated-orcid":true,"given":"Zhanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University"},{"name":"Guangzhou Medical University"},{"name":"Chinese Academy of Medical Sciences"},{"name":"Furtwangen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-0427","authenticated-orcid":true,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"pmeaae8d7cbib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2025.155366","type":"journal-article","article-title":"Sex-dependent differences in regional lung mechanics; a retrospective observational study","volume":"92","author":"Aydeniz","year":"2026","journal-title":"J. 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