{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T14:27:06Z","timestamp":1765031226530,"version":"3.46.0"},"reference-count":53,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"crossref","award":["Fellowship to PA; Project BSC0302"],"award-info":[{"award-number":["Fellowship to PA; Project BSC0302"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Phys. Biol."],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melanogenesis is a highly regulated process through which the pigment melanin is produced in skin cells. Irregularities in the molecular events that govern the process of skin pigmentation can cause disorders like vitiligo. In order to understand the biology of disease progression, it is important to have an in depth understanding of intracellular events. Mathematical models provide an integrated view of intracellular signalling. There are very few models to date that incorporate intracellular processes relevant to melanogenesis and only one to our knowledge that simulates the dynamics of response to varying levels of input. Here, we report the formulation of the largest Boolean model (265 nodes) for melanogenesis to date. The model was built on the basis of a detailed interaction network graph published by Raghunath\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    . Through additional manual curation of the reported interactions, we converted the graph into a set of Boolean rules, following the procedure of the first Boolean model (62 nodes) for melanogenesis published by Lee\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    . Simulations show that the predicted response to varying UV levels for most of the nodes is similar to the predictions of the existing model. The greater complexity allows investigation of the sensitivity of melanin to additional nodes. We carried out perturbation analysis of the network through node deletion and constitutive activation to identify sensitivity of outcomes, and compared the nodes identified as sensitive to previous reports.\n                  <\/jats:p>","DOI":"10.1088\/1478-3975\/abd3dd","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T17:30:57Z","timestamp":1608053457000},"page":"026004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Boolean model for melanogenesis"],"prefix":"10.1088","volume":"18","author":[{"given":"Pooja","family":"Dnyane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-0796","authenticated-orcid":false,"given":"Chetan","family":"Gadgil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"pbabd3ddbib1","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1038\/d41586-018-07429-3","type":"journal-article","article-title":"Superpowered skin","volume":"563","author":"Gould","year":"2018","journal-title":"Nature"},{"key":"pbabd3ddbib2","doi-asserted-by":"publisher","first-page":"10305","DOI":"10.1038\/srep10305","type":"journal-article","article-title":"A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation","volume":"5","author":"Lee","year":"2015","journal-title":"Sci. Rep."},{"key":"pbabd3ddbib3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/s0738-081x(98)00023-6","type":"journal-article","article-title":"Animals under the sun: effects of ultraviolet radiation on mammalian skin","volume":"16","author":"Slominski","year":"1998","journal-title":"Clin. Dermatol."},{"key":"pbabd3ddbib4","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nchembio.1548","type":"journal-article","article-title":"Multifaceted pathways protect human skin from UV radiation","volume":"10","author":"Natarajan","year":"2014","journal-title":"Nat. Chem. Biol."},{"year":"2012","author":"Park","key":"pbabd3ddbib5","type":"book"},{"key":"pbabd3ddbib6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.addr.2013.12.006","type":"journal-article","article-title":"The use of skin models in drug development","volume":"69\u201370","author":"Mathes","year":"2014","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"pbabd3ddbib7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","type":"journal-article","article-title":"Metabolic stability and epigenesis in randomly constructed genetic nets","volume":"22","author":"Kauffman","year":"1969","journal-title":"J. Theor. Biol."},{"key":"pbabd3ddbib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0022-5193(03)00035-3","type":"journal-article","article-title":"The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster","volume":"223","author":"Albert","year":"2003","journal-title":"J. Theor. Biol."},{"key":"pbabd3ddbib9","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1371\/journal.pcbi.0030163","type":"journal-article","article-title":"A logical model provides insights into T cell receptor signaling","volume":"3","author":"Saez-Rodriguez","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"pbabd3ddbib10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/bioinformatics\/btl210","type":"journal-article","article-title":"Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle","volume":"22","author":"Faur\u00e9","year":"2006","journal-title":"Bioinformatics"},{"key":"pbabd3ddbib11","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/9\/5\/055001","type":"journal-article","article-title":"Boolean modeling in systems biology: an overview of methodology and applications","volume":"9","author":"Wang","year":"2012","journal-title":"Phys. Biol."},{"key":"pbabd3ddbib12","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1016\/S0021-9258(19)50597-X","type":"journal-article","article-title":"Analysis of a kinetic model for melanin biosynthesis pathway","volume":"267","author":"Rodr\u00edguez-L\u00f3pez","year":"1992","journal-title":"J. Biol. Chem."},{"key":"pbabd3ddbib13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/sita.200300026","type":"journal-article","article-title":"An integrated model for melanocyte-specific gene expression and melanogenesis","volume":"3","author":"Emir","year":"2003","journal-title":"Signal Transduct."},{"key":"pbabd3ddbib14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1752-0509-3-60","type":"journal-article","article-title":"The mathematics of tanning","volume":"3","author":"Thingnes","year":"2009","journal-title":"BMC Syst. Biol."},{"key":"pbabd3ddbib15","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1006\/jtbi.2001.2521","type":"journal-article","article-title":"The regulatory basis of melanogenic switching","volume":"215","author":"\u00d8yehaug","year":"2002","journal-title":"J. Theor. Biol."},{"key":"pbabd3ddbib16","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13104-015-1128-6","type":"journal-article","article-title":"A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components","volume":"8","author":"Raghunath","year":"2015","journal-title":"BMC Res. Notes"},{"key":"pbabd3ddbib17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12895-018-0070-4","type":"journal-article","article-title":"Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach","volume":"18","author":"Subramanian","year":"2018","journal-title":"BMC Dermatol."},{"key":"pbabd3ddbib18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/sj.cdd.4400929","type":"journal-article","article-title":"Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C","volume":"9","author":"Denning","year":"2002","journal-title":"Cell Death Differ."},{"key":"pbabd3ddbib19","doi-asserted-by":"publisher","first-page":"19346","DOI":"10.1074\/jbc.m200401200","type":"journal-article","article-title":"Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes","volume":"277","author":"Sitailo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"pbabd3ddbib20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/s0006-291x(03)00345-0","type":"journal-article","article-title":"The \u03b7 isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes","volume":"303","author":"Matsumura","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"pbabd3ddbib21","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1084\/jem.20031771","type":"journal-article","article-title":"p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils","volume":"199","author":"Alvarado-Kristensson","year":"2004","journal-title":"J. Exp. Med."},{"key":"pbabd3ddbib22","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1042\/bj20082061","type":"journal-article","article-title":"Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity","volume":"419","author":"Wu","year":"2009","journal-title":"Biochem. J."},{"key":"pbabd3ddbib23","doi-asserted-by":"publisher","first-page":"00026","DOI":"10.3389\/fcell.2015.00026","type":"journal-article","article-title":"PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors","volume":"3","author":"Berthon","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"pbabd3ddbib24","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/ijms17071144","type":"journal-article","article-title":"Signaling pathways in melanogenesis","volume":"17","author":"D\u2019Mello","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"pbabd3ddbib25","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.1074\/jbc.275.15.10761","type":"journal-article","article-title":"Akt\/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein","volume":"275","author":"Pugazhenthi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"pbabd3ddbib26","doi-asserted-by":"publisher","first-page":"24039","DOI":"10.1074\/jbc.m109907200","type":"journal-article","article-title":"Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation","volume":"277","author":"She","year":"2002","journal-title":"J. Biol. Chem."},{"key":"pbabd3ddbib27","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1002\/jcb.24147","type":"journal-article","article-title":"PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells","volume":"113","author":"Zhang","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"pbabd3ddbib28","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.3390\/ijms10094066","type":"journal-article","article-title":"Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration","volume":"10","author":"Ebanks","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"pbabd3ddbib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1049\/iet-syb.2017.0039","type":"journal-article","article-title":"Method for identification of sensitive nodes in Boolean models of biological networks","volume":"12","author":"Dnyane","year":"2017","journal-title":"IET Syst. Biol."},{"key":"pbabd3ddbib30","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/j.0022-202x.2005.23760.x","type":"journal-article","article-title":"Mechanisms of skin tanning in different racial\/ethnic groups in response to ultraviolet radiation","volume":"124","author":"Tadokoro","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib31","first-page":"3219","type":"journal-article","article-title":"Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion","volume":"9","author":"Gillardon","year":"1994","journal-title":"Oncogene"},{"key":"pbabd3ddbib32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1046\/j.1523-1747.1998.00276.x","type":"journal-article","article-title":"Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model","volume":"111","author":"Scott","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1600-0749.1995.tb00670.x","type":"journal-article","article-title":"Ex vivo reconstruction of the epidermis with melanocytes and the influence of UVB","volume":"8","author":"Bessou","year":"1995","journal-title":"Pigm. Cell Res."},{"key":"pbabd3ddbib34","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/sj.jid.5700124","type":"journal-article","article-title":"UVA\/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members","volume":"126","author":"Bivik","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-4598-3-7","type":"journal-article","article-title":"Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-\u03baB\/I\u03baB pathway","volume":"3","author":"St-Germain","year":"2004","journal-title":"Mol. Cancer"},{"key":"pbabd3ddbib36","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1021\/np100281g","type":"journal-article","article-title":"Inhibition of melanogenesis and oxidation by protocatechuic acid from origanum vulgare(oregano)","volume":"73","author":"Chou","year":"2010","journal-title":"J. Nat. Prod."},{"key":"pbabd3ddbib37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/exd.12099","type":"journal-article","article-title":"9-cisretinoic acid is the ALDH1A1 product that stimulates melanogenesis","volume":"22","author":"Paterson","year":"2013","journal-title":"Exp. Dermatol."},{"key":"pbabd3ddbib38","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1271\/bbb.100851","type":"journal-article","article-title":"Inhibitory effect of [6]-Gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action","volume":"75","author":"Huang","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"pbabd3ddbib39","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/sj.jid.5700588","type":"journal-article","article-title":"Regulation of NF-\u03baB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair","volume":"127","author":"Adams","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib40","doi-asserted-by":"publisher","first-page":"8293","DOI":"10.3390\/ijms15058293","type":"journal-article","article-title":"Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of anti-pigmenting agents","volume":"15","author":"Imokawa","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"pbabd3ddbib41","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/34681","type":"journal-article","article-title":"MAP kinase links the transcription factor microphthalmia to c-Kit signalling in melanocytes","volume":"391","author":"Hemesath","year":"1998","journal-title":"Nature"},{"key":"pbabd3ddbib42","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00018-004-4189-6","type":"journal-article","article-title":"Signal transduction via the stem cell factor receptor\/c-Kit","volume":"61","author":"R\u00f6nnstrand","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"pbabd3ddbib43","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1093\/emboj\/19.12.2900","type":"journal-article","article-title":"Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes","volume":"19","author":"Busc\u00e0","year":"2000","journal-title":"EMBO J."},{"key":"pbabd3ddbib44","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1006\/bbrc.1999.0400","type":"journal-article","article-title":"Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1","volume":"256","author":"Fang","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"pbabd3ddbib45","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/j.1755-148x.2009.00610.x","type":"journal-article","article-title":"Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function","volume":"22","author":"Simon","year":"2009","journal-title":"Pigm. Cell Melanoma Res."},{"key":"pbabd3ddbib46","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/1523-1747.ep12324134","type":"journal-article","article-title":"Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for \u221d MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes","volume":"105","author":"Chakraborty","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib47","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1007\/s00018-004-4341-3","type":"journal-article","article-title":"Terrein: a new melanogenesis inhibitor and its mechanism CMLS","volume":"61","author":"Park","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"pbabd3ddbib48","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1271\/bbb.80766","type":"journal-article","article-title":"Fermented rice bran downregulates MITF expression and leads to inhibition of \u03b1-MSH-induced melanogenesis in B16F1 melanoma","volume":"73","author":"Chung","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"pbabd3ddbib49","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1038\/jid.2014.202","type":"journal-article","article-title":"Inhibition of melanogenesis by the antidiabetic metformin","volume":"134","author":"Lehraiki","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"pbabd3ddbib50","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1755-148x.2008.00503.x","type":"journal-article","article-title":"NDRG2 gene expression in B16F10 melanoma cells restrains melanogenesis via inhibition of Mitf expression","volume":"21","author":"Kim","year":"2008","journal-title":"Pigm. Cell Melanoma Res."},{"key":"pbabd3ddbib51","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/j.ajpath.2013.02.016","type":"journal-article","article-title":"The c-rel subunit of NF-\u03baB regulates epidermal homeostasis and promotes skin fibrosis in mice","volume":"182","author":"Fullard","year":"2013","journal-title":"Am. J. Pathol."},{"key":"pbabd3ddbib52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cell.2005.10.043","type":"journal-article","article-title":"A global map of p53 transcription-factor binding sites in the human genome","volume":"124","author":"Wei","year":"2006","journal-title":"Cell"},{"key":"pbabd3ddbib53","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1074\/jbc.m512167200","type":"journal-article","article-title":"Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Physical Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T14:24:37Z","timestamp":1765031077000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/abd3dd"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,17]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1478-3975\/abd3dd","relation":{},"ISSN":["1478-3967","1478-3975"],"issn-type":[{"type":"print","value":"1478-3967"},{"type":"electronic","value":"1478-3975"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"Boolean model for melanogenesis","name":"article_title","label":"Article Title"},{"value":"Physical Biology","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2021 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-07-28","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-12-15","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-02-17","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}