{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:45:02Z","timestamp":1791935102044,"version":"4.3.4"},"reference-count":0,"publisher":"IOP Publishing","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phys. Biol."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background:The Avrami-Dobrzy\u0144ski (A-D) model interprets malignant transformation as a phase-transition-like process, mathematically equivalent to the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equation from condensed-matter physics.In this framework, the cumulative probability of neoplastic transformation follows a Weibull-type sigmoidal function of the somatic mutation burden, parametrised by a shape constant a and a critical scaling exponent k.&amp;#xD;Purpose: To test the generalisability of the A-D model by fitting its cumulative distribution function to clinical mutation-count data spanning 24 cancer types, and to analyse meaning of its parameters across a heterogeneous patient population.&amp;#xD;Methods: Mutation-count data for 70 studies (24 tumour types, n \u2265 100 per study) were retrieved from cBioPortal. For each cohort, an empirical cumulative distribution P(m) was constructed from total non-synonymous mutation counts per sample. One-, two-, and three-component A-D mixture models (equivalent to Weibull mixture distributions) were fitted.&amp;#xD;Results: Single-component A-D fits adequately described a minority of cohorts; the majority exhibited a characteristic \"knee\" or wave-like inflection in the linearised representation, requiring two-or three-component mixture models. The scaling exponent k varied widely across and fell below unity in 37 of 136 fitted components, indicating a decreasing-hazard regime. The k-a parameter space showed systematic co-variation with mean mutation burden. Superposition of decreasing-and increasing-hazard components within individual tumour categories generated composite hazard profiles, reflecting coexisting subpopulations with distinct transformation dynamics.&amp;#xD;Conclusions:The A-D model provides a physically grounded description of mutation-driven cancer transformation across diverse tumour types. Deviations from single-component behaviour are consistent with genuine biological heterogeneity within nominal tumour categories. These findings support the broader applicability of phase-transition concepts in computational oncology and provide a quantitative framework for integrating genomic data into cancer risk modelling.<\/jats:p>","DOI":"10.1088\/1478-3975\/aeb3c2","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:52:54Z","timestamp":1791931974000},"source":"Crossref","is-referenced-by-count":0,"title":["Testing the Avrami-Dobrzy\u0144ski model of cancer transformation using mutation-count clinical data across multiple tumour types"],"prefix":"10.1088","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-9041","authenticated-orcid":false,"given":"Julianna","family":"Krasowska","sequence":"first","affiliation":[{"name":"Warsaw University of Technology Faculty of Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Fronczak","sequence":"additional","affiliation":[{"name":"Warsaw University of Technology Faculty of Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Fronczak","sequence":"additional","affiliation":[{"name":"Warsaw University of Technology Faculty of Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Reszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Mossakowski Medical Research Institute Polish Academy of Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwester","family":"Sommer","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-0189","authenticated-orcid":false,"given":"Krzysztof Wojciech","family":"Fornalski","sequence":"additional","affiliation":[{"name":"Politechnika Warszawska Wydzial Fizyki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,13]]},"container-title":["Physical Biology"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/aeb3c2","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/aeb3c2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/aeb3c2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/aeb3c2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:52:54Z","timestamp":1791931974000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1478-3975\/aeb3c2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1088\/1478-3975\/aeb3c2","relation":{},"ISSN":["1478-3967","1478-3975"],"issn-type":[{"value":"1478-3967","type":"print"},{"value":"1478-3975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]}}}