{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:47:35Z","timestamp":1787874455272,"version":"build-2784847793"},"reference-count":84,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["5-I50-RX001871-02"],"award-info":[{"award-number":["5-I50-RX001871-02"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","award":["5-R01-EB001889-10"],"award-info":[{"award-number":["5-R01-EB001889-10"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . As neural interfaces demonstrate success in chronic applications, a novel class of reshaping electrodes with patterned regions of stiffness will enable application to a widening range of anatomical locations. Patterning stiff regions and flexible regions of the electrode enables nerve reshaping while accommodating anatomical constraints of various implant locations ranging from peripheral nerves to spinal and autonomic plexi.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Introduced is a new composite electrode enabling patterning of regions of various electrode mechanical properties. The initial demonstration of the composite\u2019s capability is the composite flat interface nerve electrode (C-FINE). The C-FINE is constructed from a sandwich of patterned PEEK within layers of pliable silicone. The shape of the PEEK provides a desired pattern of stiffness: stiff across the width of the nerve to reshape the nerve, but flexible along its length to allow for bending with the nerve. This is particularly important in anatomical locations near joints or organs, and in constrained compartments. We tested pressure and volume design constraints\n                    <jats:italic>in vitro<\/jats:italic>\n                    to verify that the C-FINE can attain a safe cuff-to-nerve ratio (CNR) without impeding intraneural blood flow. We measured nerve function as well as nerve and axonal morphology following 3 month implantation of the C-FINE without wires on feline peripheral nerves in anatomically constrained areas near mobile joints and major blood vessels in both the hind and fore limbs.\n                    <jats:italic>Main Results. In vitro<\/jats:italic>\n                    inflation tests showed effective CNRs (1.93\u2009\u2009\u00b1\u2009\u20090.06) that exceeded the industry safety standard of 1.5 at an internal pressure of 20 mmHg. This is less than the 30 mmHg shown to induce loss of conduction or compromise blood flow. Implanted cats showed no changes in physiology or electrophysiology. Behavioral signs were normal suggesting healthy nerves. Motor nerve conduction velocity and compound motor action potential did not change significantly between implant and explant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&gt;\u2009\u20090.15 for all measures). Axonal density and myelin sheath thickness was not significantly different within the electrode compared to sections greater than 2\u2009cm proximal to implanted cuffs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2009&gt;\u2009\u20090.14 for all measures).\n                    <jats:italic>Significance<\/jats:italic>\n                    . We present the design and verification of a novel nerve cuff electrode, the C-FINE. Laminar manufacturing processes allow C-FINE stiffness to be configured for specific applications. Here, the central region in the configuration tested is stiff to reshape or conform to the target nerve, while edges are highly flexible to bend along its length. The C-FINE occupies less volume than other NCEs, making it suitable for implantation in highly mobile locations near joints. Design constraints during simulated transient swelling were verified\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Maintenance of nerve health in various challenging anatomical locations (sciatic and median\/ulnar nerves) was verified in a chronic feline model\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/aa6632","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T06:15:17Z","timestamp":1489385717000},"page":"036022","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["The design of and chronic tissue response to a composite nerve electrode with patterned stiffness"],"prefix":"10.1088","volume":"14","author":[{"given":"M J","family":"Freeberg","sequence":"first","affiliation":[{"name":"Case Western Reserve University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Stone","sequence":"additional","affiliation":[{"name":"Louis Stokes Cleveland Department of Veterans\u2019 Affairs Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Triolo","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"},{"name":"Case Western Reserve University"},{"name":"Louis Stokes Cleveland Department of Veterans\u2019 Affairs Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Tyler","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"},{"name":"Louis Stokes Cleveland Department of Veterans\u2019 Affairs Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"jneaa6632bib001","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1109\/TNSRE.2008.2003390","type":"journal-article","article-title":"Standing after spinal cord injury with four-contact nerve-cuff electrodes for quadriceps stimulation","volume":"16","author":"Fisher","year":"2008","journal-title":"IEEE Trans. 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