{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T14:05:55Z","timestamp":1779545155620,"version":"3.53.1"},"reference-count":40,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"crossref","award":["N66001-15-2-4060"],"award-info":[{"award-number":["N66001-15-2-4060"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Artificial modulation of peripheral nerve signals (neuromodulation) by electrical stimulation is an innovation with potential to develop treatments that replace or supplement drugs. One function of the nervous system that can be exploited by neuromodulation is regulation of disease intensity. Optimal interfacing of devices with the nervous system requires suitable models of peripheral nerve systems so that closed-loop control can be utilized for therapeutic benefit.\n                    <jats:italic>Approach<\/jats:italic>\n                    . We use physiological data to model afferent signaling in the vagus nerve that carries information about inflammation in the small intestine to the brain.\n                    <jats:italic>Main results<\/jats:italic>\n                    . The vagal nerve signaling system is distributed and complex; however, we propose a class of reductive models using a state-space formalism that can be tuned in a patient-specific manner.\n                    <jats:italic>Significance<\/jats:italic>\n                    . These models provide excellent fits to a large range of nerve recording data but are computationally simple enough for feedback control in implantable neuromodulation devices.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/aad96d","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T07:00:14Z","timestamp":1533884414000},"page":"056032","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Modeling experimental recordings of vagal afferent signaling of intestinal inflammation for neuromodulation"],"prefix":"10.1088","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6918-9054","authenticated-orcid":false,"given":"Elma","family":"O\u2019Sullivan-Greene","sequence":"first","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-8569","authenticated-orcid":false,"given":"Tatiana","family":"Kameneva","sequence":"additional","affiliation":[{"name":"The University of Melbourne"},{"name":"Swinburne University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Trevaks","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Shafton","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-2275","authenticated-orcid":false,"given":"Sophie C","family":"Payne","sequence":"additional","affiliation":[{"name":"Bionics Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-5656","authenticated-orcid":false,"given":"Robin","family":"McAllen","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-3438","authenticated-orcid":false,"given":"John B","family":"Furness","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health"},{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5497-7234","authenticated-orcid":false,"given":"David B","family":"Grayden","sequence":"additional","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"jneaad96dbib001","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1109\/10.83570","type":"journal-article","article-title":"Feedback control of coronal plane hip angle in paraplegic subjects using functional neuromuscular stimulation","volume":"38","author":"Abbas","year":"1991","journal-title":"IEEE Trans. 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