{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:39:33Z","timestamp":1788809973351,"version":"build-2803163510"},"reference-count":27,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"tdm","delay-in-days":20,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R24MH109060"],"award-info":[{"award-number":["R24MH109060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods.\n                    <jats:italic>Approach.<\/jats:italic>\n                    This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain.\n                    <jats:italic>Significance.<\/jats:italic>\n                    This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging, and guiding treatment of epilepsy and other brain disorders characterized by abnormal rhythms.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/abb63a","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T18:30:28Z","timestamp":1599589828000},"page":"056040","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy"],"prefix":"10.1088","volume":"17","author":[{"given":"Andres","family":"Barragan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-0308","authenticated-orcid":false,"given":"Chet","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Bera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Weinand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willard","family":"Kasoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-8025","authenticated-orcid":false,"given":"Russell S","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"jneabb63abib1","doi-asserted-by":"publisher","first-page":"1852 \u20137","DOI":"10.1109\/TMI.2019.2898090","type":"journal-article","article-title":"Mapping biological current densities with ultrafast acoustoelectric imaging: application to the beating rat heart","volume":"38","author":"Berthon","year":"2019","journal-title":"IEEE Trans. Med. Imaging"},{"key":"jneabb63abib2","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1088\/1361-6560\/aa6ee7","type":"journal-article","article-title":"An integrated and highly sensitive ultrafast acoustoelectric imaging system for biomedical applications","volume":"62","author":"Berthon","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"jneabb63abib3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1046\/j.1535-7597.2003.03201.x","type":"journal-article","article-title":"A greater role for surgical treatment of epilepsy: why and when?","volume":"3","author":"Engel","year":"2003","journal-title":"Epilepsy Curr."},{"key":"jneabb63abib4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40349-015-0030-y","type":"journal-article","article-title":"Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS","volume":"3","author":"Farrer","year":"2015","journal-title":"J. Ther. Ultrasound"},{"key":"jneabb63abib5","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ijpsycho.2014.10.013","type":"journal-article","article-title":"The use of current source density as electrophysiological correlates in neuropsychiatric disorders: a review of human studies","volume":"97","author":"Kamarajan","year":"2015","journal-title":"Int. J. Psychophysiol."},{"key":"jneabb63abib6","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1016\/j.msec.2012.07.024","type":"journal-article","article-title":"Comparison of electrical conductivities of various brain phantom gels developing a \u2018brain gel model\u2019","volume":"32","author":"Kandadai","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"jneabb63abib7","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1038\/s41598-020-58612-4","type":"journal-article","article-title":"Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: differences between NREM sleep and REM sleep","volume":"10","author":"Kang","year":"2020","journal-title":"Sci. Rep."},{"key":"jneabb63abib8","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.neuroimage.2010.02.067","type":"journal-article","article-title":"Source localization of ictal epileptic activity investigated by high resolution EEG and validated by SEEG","volume":"51","author":"Koessler","year":"2010","journal-title":"Neuroimage"},{"key":"jneabb63abib9","doi-asserted-by":"publisher","first-page":"5929","DOI":"10.1088\/0031-9155\/57\/19\/5929","type":"journal-article","article-title":"Measuring the acoustoelectric interaction constant using ultrasound current source density imaging","volume":"57","author":"Li","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"jneabb63abib10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14896","type":"journal-article","article-title":"Human seizures couple across spatial scales through travelling wave dynamics","volume":"8","author":"Martinet","year":"2017","journal-title":"Nat. Commun."},{"key":"jneabb63abib11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1109\/ULTSYM.2009.5441400","type":"conference-proceedings","article-title":"Ultrasound current source density imaging of a time-varying current field in a multielectrode nerve chamber","author":"Olafsson","year":"2009"},{"key":"jneabb63abib12","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1109\/TBME.2008.919115","type":"journal-article","article-title":"Ultrasound current source density imaging","volume":"55","author":"Olafsson","year":"2008","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"jneabb63abib13","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/brain\/awz015","type":"journal-article","article-title":"Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: a prospective long-term study","volume":"142","author":"Plummer","year":"2019","journal-title":"Brain"},{"key":"jneabb63abib14","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab6fc3","type":"journal-article","article-title":"High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator","volume":"17","author":"Preston","year":"2020","journal-title":"J. Neural. Eng."},{"key":"jneabb63abib15","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1016\/j.ultrasmedbio.2018.06.021","type":"journal-article","article-title":"Mapping current patterns generated by a clinical deep brain stimulator using acoustoelectric imaging","volume":"44","author":"Preston","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"jneabb63abib16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/ULTSYM.2016.7728868","type":"conference-proceedings","article-title":"4D acoustoelectric imaging of current sources in a human head phantom","author":"Qin","year":"2016"},{"key":"jneabb63abib17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/ULTSYM.2017.8092671","type":"conference-proceedings","article-title":"Performance of a transcranial US array designed for 4D acoustoelectric brain imaging in humans","author":"Qin","year":"2017"},{"key":"jneabb63abib18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1109\/TBME.2014.2345771","type":"journal-article","article-title":"Ultrasound current source density imaging of the cardiac activation wave using a clinical cardiac catheter","volume":"62","author":"Qin","year":"2015","journal-title":"IEEE Trans. BME"},{"key":"jneabb63abib19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.seizure.2016.05.018","type":"journal-article","article-title":"Correlation of invasive EEG and scalp EEG","volume":"41","author":"Ramantani","year":"2016","journal-title":"Seizure"},{"key":"jneabb63abib20","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1038\/s41467-020-15781-0","type":"journal-article","article-title":"Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources","volume":"11","author":"Sohrabpour","year":"2020","journal-title":"Nat. Commun."},{"key":"jneabb63abib21","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/s41596-018-0009-6","type":"journal-article","article-title":"Integrated analysis of anatomical and electrophysiological human intracranial data","volume":"13","author":"Stolk","year":"2018","journal-title":"Nat. Protoc."},{"key":"jneabb63abib22","doi-asserted-by":"publisher","DOI":"10.1063\/1.3632034","type":"journal-article","article-title":"Four-dimensional ultrasound current source density imaging of a dipole field","volume":"99","author":"Wang","year":"2011","journal-title":"Appl. Phys. Lett."},{"key":"jneabb63abib23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1684\/epd.2016.0825","type":"journal-article","article-title":"Surgery for epilepsy: a systematic review of current evidence","volume":"18","author":"West","year":"2016","journal-title":"Epileptic Disord."},{"key":"jneabb63abib24","article-title":"In vivo swine model for developing and validating acoustoelectric brain imaging: towards noninvasive, real-time 4D electrical brain mapping","author":"Wilhite","year":"2019","type":"other"},{"key":"jneabb63abib25","doi-asserted-by":"publisher","DOI":"10.1063\/1.2724901","type":"journal-article","article-title":"Imaging current flow in lobster nerve cord using the acoustoelectric effect","volume":"90","author":"Witte","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"jneabb63abib26","article-title":"High-resolution mapping of bio-electric fields","author":"Witte","year":"2011","type":"patent"},{"key":"jneabb63abib27","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1109\/TBME.2012.2228641","type":"journal-article","article-title":"A 3-D reconstruction solution to current density imaging based on acoustoelectric effect by deconvolution: a simulation study","volume":"60","author":"Yang","year":"2013","journal-title":"IEEE Trans. Biomed. Eng."}],"container-title":["Journal of Neural Engineering"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T13:18:05Z","timestamp":1768655885000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb63a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,10,21]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1741-2552\/abb63a","relation":{},"ISSN":["1741-2560","1741-2552"],"issn-type":[{"value":"1741-2560","type":"print"},{"value":"1741-2552","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]},"assertion":[{"value":"Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy","name":"article_title","label":"Article Title"},{"value":"Journal of Neural Engineering","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-05-28","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-08","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-10-21","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}