{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:27:52Z","timestamp":1768836472477,"version":"3.49.0"},"reference-count":152,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":27,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Spanish Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","award":["MAT2016-76847-R"],"award-info":[{"award-number":["MAT2016-76847-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ERDF\/FEDER Operative Program of the Region of Murcia","award":["Project No. 14-20\/20"],"award-info":[{"award-number":["Project No. 14-20\/20"]}]},{"name":"National Institute for Agricultural and Food Research and Technology (INIA) and the Spanish State Research Agency (AEI) program INIA-CCAA","award":["Research contract (ADAC)"],"award-info":[{"award-number":["Research contract (ADAC)"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["Neurocentro-B2017\/BMD-3760"],"award-info":[{"award-number":["Neurocentro-B2017\/BMD-3760"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Age-related macular degeneration is an incurable chronic neurodegenerative disease, causing progressive loss of the central vision and even blindness. Up-to-date therapeutic approaches can only slow down he progression of the disease.\n                    <jats:italic>Objective.<\/jats:italic>\n                    Feasibility study for a multilayered, silk\nfibroin-based, 3D biohybrid retina.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Fabrication of silk fibroin-based biofilms; culture of different types of cells: retinal pigment epithelium, retinal neurons, M\u00fcller and mesenchymal stem cells ; creation of a layered structure glued with silk fibroin hydrogel.\n                    <jats:italic>Main results<\/jats:italic>\n                    .\n                    <jats:italic>In vitro<\/jats:italic>\n                    evidence for the feasibility of layered 3D biohybrid retinas; primary culture neurons grow and develop neurites on silk fibroin biofilms, either alone or in presence of other cells cultivated on the same biomaterial; cell organization and cellular phenotypes are maintained\n                    <jats:italic>in vitro<\/jats:italic>\n                    for the seven days of the experiment.\n                    <jats:italic>Significance.<\/jats:italic>\n                    3D biohybrid retina can be built using silk\nsilkworm fibroin\nfilms and hydrogels to be used in cell replacement therapy for AMD and similar\nretinal neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/abb9c0","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T18:15:30Z","timestamp":1600452930000},"page":"055003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)"],"prefix":"10.1088","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-0262","authenticated-orcid":false,"given":"Nahla","family":"Jemni-Damer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atocha","family":"Guedan-Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Cichy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Lozano-Picazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-729X","authenticated-orcid":false,"given":"Daniel","family":"Gonzalez-Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-8398","authenticated-orcid":false,"given":"Jos\u00e9","family":"Perez-Rigueiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"V. Guinea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Virtuoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-7453","authenticated-orcid":false,"given":"Michele","family":"Papa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Armada-Maresca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlota","family":"Largo-Aramburu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador D","family":"Aznar-Cervantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L","family":"Cenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0897-411X","authenticated-orcid":false,"given":"Fivos","family":"Panetsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"jneabb9c0bib1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.eurger.2014.09.007","type":"journal-article","article-title":"Age related macular degeneration \u2013 challenge for future: pathogenesis and new perspectives for the treatment","volume":"6","author":"Michalska-Ma\u0142ecka","year":"2015","journal-title":"European Geriatric Medicine"},{"key":"jneabb9c0bib2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","type":"journal-article","article-title":"Mechanisms of age-related macular degeneration","volume":"75","author":"Ambati","year":"2012","journal-title":"Neuron"},{"key":"jneabb9c0bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00002512-200219020-00003","type":"journal-article","article-title":"Age-related macular degeneration","volume":"19","author":"Lacour","year":"2002","journal-title":"Drugs & Aging"},{"key":"jneabb9c0bib4","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1056\/NEJMra0801537","type":"journal-article","article-title":"Age-related macular degeneration","volume":"358","author":"Jager","year":"2008","journal-title":"New Engl. J. Med."},{"key":"jneabb9c0bib5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","type":"journal-article","article-title":"Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases","volume":"43","author":"Cuenca","year":"2014","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","type":"journal-article","article-title":"The dynamic nature of Bruch\u2019s membrane","volume":"29","author":"Booij","year":"2010","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib7","first-page":"p 687","type":"book","article-title":"","author":"Hogan","year":"1971"},{"key":"jneabb9c0bib8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.preteyeres.2013.07.003","type":"journal-article","article-title":"Aging is not a disease: distinguishing age-related macular degeneration from aging","volume":"37","author":"Ardeljan","year":"2013","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40101-016-0091-9","type":"journal-article","article-title":"Light-sensitive brain pathways and aging","volume":"35","author":"Daneault","year":"2016","journal-title":"J. Physiol. Anthropol."},{"key":"jneabb9c0bib10","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/S0161-6420(87)33308-1","type":"journal-article","article-title":"The dimensions of the problem of eye disease among the elderly","volume":"94","author":"Pizzarello","year":"1987","journal-title":"Ophthalmology"},{"key":"jneabb9c0bib11","first-page":"32","type":"journal-article","article-title":"Oxidative damage and age-related macular degeneration","volume":"5","author":"Winkler","year":"1999","journal-title":"Mol. Vis."},{"key":"jneabb9c0bib12","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.arr.2015.09.002","type":"journal-article","article-title":"RPE necroptosis in response to oxidative stress and in AMD","volume":"24","author":"Hanus","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"jneabb9c0bib13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/s0039-6257(00)00140-5","type":"journal-article","article-title":"The role of oxidative stress in the pathogenesis of age-related macular degeneration","volume":"45","author":"Beatty","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"jneabb9c0bib14","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","type":"journal-article","article-title":"Consequences of oxidative stress in age-related macular degeneration","volume":"33","author":"Jarrett","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"jneabb9c0bib15","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","type":"journal-article","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"jneabb9c0bib16","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/hmg\/ddi353","type":"journal-article","article-title":"Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk","volume":"14","author":"Rivera","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"jneabb9c0bib17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/cge.12206","type":"journal-article","article-title":"Age-related macular degeneration-clinical review and genetics update","volume":"84","author":"Ratnapriya","year":"2013","journal-title":"Clin. Genet."},{"key":"jneabb9c0bib18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.medici.2016.02.004","type":"journal-article","article-title":"Genetic factors associated with the development of age-related macular degeneration","volume":"52","author":"Sergejeva","year":"2016","journal-title":"Medicina"},{"key":"jneabb9c0bib19","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","type":"journal-article","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"jneabb9c0bib20","first-page":"82","type":"journal-article","article-title":"Age-related macular degeneration","volume":"74","author":"McConnell","year":"2005","journal-title":"Ulster Med. J."},{"key":"jneabb9c0bib21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1157\/1309001610.1157\/13090016","type":"journal-article","article-title":"Epidemiolog\u00eda de la degeneraci\u00f3n macular asociada con la edad. Situaci\u00f3n en Espa\u00f1a","volume":"38","author":"Dami\u00e1n","year":"2006","journal-title":"Atencion Primaria"},{"key":"jneabb9c0bib22","first-page":"745","author":"Marmor","year":"1998","type":"book"},{"key":"jneabb9c0bib23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.eurger.2014.09.007","type":"journal-article","article-title":"Age related macular degeneration \u2013 challenge for future: pathogenesis and new perspectives for the treatment","volume":"6","author":"Michalska-Ma\u0142ecka","year":"2015","journal-title":"Eur. Geriatr. Med."},{"key":"jneabb9c0bib24","first-page":"312","type":"report","article-title":"Prevent blindness. forecasting the prevalence and costs of vision problemsForecasting the Prevalence and Costs of Vision Problems","volume":"60603","author":"Wittenborn","year":"2014"},{"key":"jneabb9c0bib25","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","type":"journal-article","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"jneabb9c0bib26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/4568979","type":"journal-article","article-title":"Cell therapy for retinal dystrophies: from cell suspension formulation to complex retinal tissue bioengineering","volume":"4568979","author":"Ben M\u2019Barek","year":"2019","journal-title":"Stem Cells Int."},{"key":"jneabb9c0bib27","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2018.11.003","type":"journal-article","article-title":"Stemming retinal regeneration with pluripotent stem cells","volume":"69","author":"Jin","year":"2019","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib28","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s40610-017-0069-3","type":"journal-article","article-title":"Recent advances in retinal stem cell therapy","volume":"3","author":"Bhattacharya","year":"2017","journal-title":"Curr. Mol. Biol. Rep."},{"key":"jneabb9c0bib29","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/sctm.18-0282","type":"journal-article","article-title":"Concise review: update on retinal pigment epithelium transplantation for age-related macular degeneration","volume":"8","author":"Zarbin","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"jneabb9c0bib30","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.preteyeres.2007.02.002","type":"journal-article","article-title":"Transplantation of the RPE in AMD","volume":"26","author":"Binder","year":"2007","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib31","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.stem.2018.05.013","type":"journal-article","article-title":"Regenerating eye tissues to preserve and restore vision","volume":"22","author":"Stern","year":"2018","journal-title":"Cell Stem Cell"},{"key":"jneabb9c0bib32","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1089\/ten.tea.2015.0373","type":"journal-article","article-title":"Control of retinal ganglion cell positioning and neurite growth: combining 3D printing with radial electrospun scaffolds","volume":"22","author":"Kador","year":"2016","journal-title":"Tissue Eng. A"},{"key":"jneabb9c0bib33","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1002\/stem.520","type":"journal-article","article-title":"Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation","volume":"28","author":"West","year":"2010","journal-title":"Stem Cells"},{"key":"jneabb9c0bib34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.11.001","type":"journal-article","article-title":"Transplantation of photoreceptors into the degenerative retina: current state and future perspectives","volume":"69","author":"Gasparini","year":"2019","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2019.03.001","type":"journal-article","article-title":"Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach","volume":"71","author":"Gagliardi","year":"2019","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-32871-8","type":"journal-article","article-title":"Three-dimensional retinal organoids facilitate the investigation of retinal ganglion cell development, organization and neurite outgrowth from human pluripotent stem cells","volume":"8","author":"Fligor","year":"2018","journal-title":"Sci. Rep."},{"key":"jneabb9c0bib37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ydbio.2017.09.028","type":"journal-article","article-title":"Organoid technology for retinal repair","volume":"433","author":"Llonch","year":"2018","journal-title":"Dev. Biol."},{"key":"jneabb9c0bib38","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.stemcr.2019.09.009","type":"journal-article","article-title":"Improved retinal organoid differentiation by modulating signaling pathways revealed by comparative transcriptome analyses with development in vivo","volume":"13","author":"Brooks","year":"2019","journal-title":"Stem Cell Rep."},{"key":"jneabb9c0bib39","doi-asserted-by":"publisher","first-page":"1-11","DOI":"10.1177\/2041731417720841","type":"journal-article","article-title":"Scaffolds for retinal pigment epithelial cell transplantation in age-related macular degeneration","volume":"8","author":"White","year":"2017","journal-title":"J. Tissue Eng."},{"key":"jneabb9c0bib40","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1039\/b618583e","type":"journal-article","article-title":"Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space","volume":"7","author":"Tao","year":"2007","journal-title":"Lab Chip"},{"key":"jneabb9c0bib41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3791\/53927","type":"journal-article","article-title":"A step by step protocol for subretinal surgery in rabbits","volume":"115","author":"Maminishkis","year":"2016","journal-title":"J. Visualized Exp."},{"key":"jneabb9c0bib42","doi-asserted-by":"publisher","first-page":"e688","DOI":"10.1111\/aos.14004","type":"journal-article","article-title":"Survival and functionality of xeno-free human embryonic stem cell\u2013derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits","volume":"97","author":"Ilmarinen","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"jneabb9c0bib43","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1163\/156856298X00721","type":"journal-article","article-title":"Retinal pigment epithelium cell culture on thin biodegradable poly(DL-lactic-co-glycolic acid) films","volume":"9","author":"Lu","year":"1998","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"jneabb9c0bib44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep14326","type":"journal-article","article-title":"Electrospun SF\/PLCL nanofibrous membrane: A potential scaffold for retinal progenitor cell proliferation and differentiation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"jneabb9c0bib45","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1167\/iovs.17-23157","type":"journal-article","article-title":"Characterization of human iPSC-RPE on a prosthetic bruch\u2019s membrane manufactured from silk fibroin","volume":"59","author":"Galloway","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"jneabb9c0bib46","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/j.biomaterials.2006.11.023","type":"journal-article","article-title":"Thin collagen film scaffolds for retinal epithelial cell culture","volume":"28","author":"Lu","year":"2007","journal-title":"Biomaterials"},{"key":"jneabb9c0bib47","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.carbpol.2012.10.028","type":"journal-article","article-title":"Hyaluronic acid based scaffolds for tissue engineering - A review","volume":"92","author":"Collins","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"jneabb9c0bib48","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.3390\/ma7043106","type":"journal-article","article-title":"Gelatin-based materials in ocular tissue engineering","volume":"7","author":"Rose","year":"2014","journal-title":"Materials"},{"key":"jneabb9c0bib49","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41433-018-0061-z","type":"journal-article","article-title":"Cellular regeneration strategies for macular degeneration: past, present and future","volume":"32","author":"Chichagova","year":"2018","journal-title":"Eye"},{"key":"jneabb9c0bib50","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s13770-020-00254-8","type":"journal-article","article-title":"Retinal tissue bioengineering, materials and methods for the treatment of glaucoma","volume":"17","author":"Behtaj","year":"2020","journal-title":"Tissue Eng. Regener. Med."},{"key":"jneabb9c0bib51","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1136\/bjophthalmol-2013-304446","type":"journal-article","article-title":"Innovations in 3D printing: A 3D overview from optics to organs","volume":"98","author":"Schubert","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"jneabb9c0bib52","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/s0002-9394(14)73079-x","type":"journal-article","article-title":"Experimental transplantation of human retinal pigment epithelial cells on collagen substrates","volume":"117","author":"Bhatt","year":"1994","journal-title":"Am. J. Ophthalmol."},{"key":"jneabb9c0bib53","doi-asserted-by":"publisher","first-page":"9414","DOI":"10.1016\/j.actbio.2013.07.029","type":"journal-article","article-title":"Primordium of an artificial Bruch\u2019s membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers","volume":"9","author":"Warnke","year":"2013","journal-title":"Acta Biomaterialia"},{"key":"jneabb9c0bib54","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1034\/j.1600-0420.2002.800408.x","type":"journal-article","article-title":"Photoreceptor survival in transplantation of autologous iris pigment epithelial cells to the subretinal space","volume":"80","author":"Crafoord","year":"2002","journal-title":"Acta Ophthalmologica Scandinavica"},{"key":"jneabb9c0bib55","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1136\/bjo.2009.176305","type":"journal-article","article-title":"Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study","volume":"95","author":"Falkner-Radler","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"jneabb9c0bib56","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1080\/02713680701604749","type":"journal-article","article-title":"The upregulation of angiogenic gene expression in cultured retinal pigment epithelial cells grown on type I collagen","volume":"32","author":"Imai","year":"2007","journal-title":"Curr. Eye Res."},{"key":"jneabb9c0bib57","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ajo.2011.06.007","type":"journal-article","article-title":"A free retinal pigment epithelium-choroid graft in patients with exudative age-related macular degeneration: results up to 7 years","volume":"153","author":"van Zeeburg","year":"2012","journal-title":"Curr. Eye Res."},{"key":"jneabb9c0bib58","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/j.biomaterials.2006.11.023","type":"journal-article","article-title":"Thin collagen film scaffolds for retinal epithelial cell culture","volume":"28","author":"Lu","year":"2007","journal-title":"Biomaterials"},{"key":"jneabb9c0bib59","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.3390\/ma7043106","type":"journal-article","article-title":"Gelatin-Based Materials in Ocular Tissue Engineering","volume":"7","author":"Rose","year":"2014","journal-title":"Materials"},{"key":"jneabb9c0bib60","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1007\/s10856-013-4961-y","type":"journal-article","article-title":"Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery","volume":"24","author":"Lai","year":"2013","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"jneabb9c0bib61","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1002\/term.2089","type":"journal-article","article-title":"A Bruch\u2019s membrane substitute fabricated from silk fibroin supports the function of retinal pigment epithelial cells in vitro","volume":"11","author":"Shadforth","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"jneabb9c0bib62","doi-asserted-by":"publisher","first-page":"9777","DOI":"10.1016\/j.biomaterials.2014.08.040","type":"journal-article","article-title":"A novel Bruch\u2019s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells","volume":"35","author":"Xiang","year":"2014","journal-title":"Biomaterials"},{"key":"jneabb9c0bib63","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3389\/fbioe.2020.00456","type":"journal-article","article-title":"Optimisation of a novel bio-substrate as a treatment for atrophic age-related macular degeneration","volume":"8","author":"McCormick","year":"2020","journal-title":"Frontiers Bioeng. Biotechnol."},{"key":"jneabb9c0bib64","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1089\/ten.1999.5.187","type":"journal-article","article-title":"Ocular cell monolayers cultured on biodegradable substrates","volume":"5","author":"Hadlock","year":"1999","journal-title":"Tissue Eng"},{"key":"jneabb9c0bib65","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/s0142-9612(00)00179-4","type":"journal-article","article-title":"Retinal pigment epithelial cell adhesion on novel micropatterned surfaces fabricated from synthetic biodegradable polymers","volume":"22","author":"Lu","year":"2001","journal-title":"Biomaterials"},{"key":"jneabb9c0bib66","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.1016\/s0042-6989(99)00128-5","type":"journal-article","article-title":"Long-term survival of retinal cell cultures on retinal implant materials","volume":"39","author":"Guenther","year":"1999","journal-title":"Vis. Res"},{"key":"jneabb9c0bib67","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3389\/fbioe.2020.00456","type":"journal-article","article-title":"Optimisation of a novel bio-substrate as a treatment for atrophic age-related macular degeneration","volume":"8","author":"McCormick","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"jneabb9c0bib68","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1016\/s0142-9612(01)00171-5","type":"journal-article","article-title":"Natural and artificial substrates for retinal pigment epithelial monolayer transplantation","volume":"22","author":"Singh","year":"2001","journal-title":"Biomaterials"},{"key":"jneabb9c0bib69","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00417-006-0296-4","type":"journal-article","article-title":"Effects of subretinal implant materials on the viability, apoptosis and barrier function of cultured RPE cells","volume":"245","author":"Wu","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"jneabb9c0bib70","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.actbio.2017.02.035","type":"journal-article","article-title":"Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering","volume":"54","author":"Calejo","year":"2017","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib71","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1167\/iovs.13-12833","type":"journal-article","article-title":"Porous poly(\u03f5-caprolactone) scaffolds for retinal pigment epithelium transplantation","volume":"55","author":"McHugh","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"jneabb9c0bib72","doi-asserted-by":"publisher","first-page":"8047","DOI":"10.1016\/j.biomaterials.2012.07.033","type":"journal-article","article-title":"Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes","volume":"33","author":"Subrizi","year":"2012","journal-title":"Biomaterials"},{"key":"jneabb9c0bib73","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1167\/iovs.03-0662","type":"journal-article","article-title":"Survival of allogeneic porcine retinal pigment epithelial sheets after subretinal transplantation","volume":"45","author":"Del Priore","year":"2004","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"jneabb9c0bib74","doi-asserted-by":"publisher","first-page":"9777","DOI":"10.1016\/j.biomaterials.2014.08.040","type":"journal-article","article-title":"A novel Bruch\u2019s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells","volume":"35","author":"Xiang","year":"2014","journal-title":"Biomaterials"},{"key":"jneabb9c0bib75","doi-asserted-by":"publisher","first-page":"64631","DOI":"10.18632\/oncotarget.11502","type":"journal-article","article-title":"Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo Oncotarget","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget."},{"key":"jneabb9c0bib76","article-title":"A study of implantation of retinal pigment epithelium in subjects with acute wet age related macular degeneration - full text view - clinicalTrials.gov.","author":"Moorfields Eye Hospital NHS Foundation Trust","year":"2020","type":"web-resource"},{"key":"jneabb9c0bib77","article-title":"Study of subretinal implantation of human embryonic stem cell-derived RPE cells in advanced dry AMD - full text view - ClinicalTrials.gov.","author":"Lebkowski","year":"2020","type":"web-resource"},{"key":"jneabb9c0bib78","article-title":"Autologous transplantation of induced pluripotent stem cell-derived retinal pigment epithelium for geographic atrophy associated with age-related macular degeneration - full text view - ClinicalTrials.gov.","author":"Wiley","year":"2020","type":"web-resource"},{"key":"jneabb9c0bib79","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/ijms20010178","type":"journal-article","article-title":"Polybenzyl glutamate biocompatible scaffold promotes the efficiency of retinal differentiation toward retinal ganglion cell lineage from human-induced pluripotent stem cells","volume":"20","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"jneabb9c0bib80","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.actbio.2017.02.032","type":"journal-article","article-title":"HiPSC-derived retinal ganglion cells grow dendritic arbors and functional axons on a tissue-engineered scaffold","volume":"54","author":"Li","year":"2017","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib81","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1089\/ten.TEA.2013.0720","type":"journal-article","article-title":"Enhanced differentiation and delivery of mouse retinal progenitor cells using a micropatterned biodegradable thin-film polycaprolactone scaffold","volume":"21","author":"Yao","year":"2015","journal-title":"Tissue Eng. Part A."},{"key":"jneabb9c0bib82","doi-asserted-by":"publisher","DOI":"10.1038\/srep14326","type":"journal-article","article-title":"Electrospun SF\/PLCL nanofibrous membrane: a potential scaffold for retinal progenitor cell proliferation and differentiation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"jneabb9c0bib83","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature10997","type":"journal-article","article-title":"Restoration of vision after transplantation of photoreceptors","volume":"485","author":"Pearson","year":"2012","journal-title":"Nature"},{"key":"jneabb9c0bib84","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/srep29784","type":"journal-article","article-title":"Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice","volume":"136:29784","author":"Barnea-Cramer","year":"2016","journal-title":"Sci. Rep."},{"key":"jneabb9c0bib85","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1038\/s41467-019-12330-2","type":"journal-article","article-title":"Restoration of visual function by transplantation of optogenetically engineered photoreceptors","volume":"10","author":"Garita-Hernandez","year":"2019","journal-title":"Nat. Commun."},{"key":"jneabb9c0bib86","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.8.3.30","type":"journal-article","article-title":"Transplantation of mature photoreceptors in rodents with retinal degeneration","volume":"8","author":"Lorach","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"jneabb9c0bib87","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.100779","type":"journal-article","article-title":"Retinal stem cell transplantation: balancing safety and potential","volume":"75","author":"Singh","year":"2020","journal-title":"Prog. Retinal Eye Res."},{"key":"jneabb9c0bib88","doi-asserted-by":"publisher","first-page":"931","DOI":"10.2147\/OPTH.S133502","type":"journal-article","article-title":"Intravitreal use of bone marrow mononuclear fraction containing CD34+ stem cells in patients with atrophic age-related macular degeneration","volume":"11","author":"Cotrim","year":"2017","journal-title":"Clin. Ophthalmol."},{"key":"jneabb9c0bib89","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ajo.2008.04.009","type":"journal-article","article-title":"Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium","volume":"146","author":"Radtke","year":"2008","journal-title":"Am. J. Ophthalmol ."},{"key":"jneabb9c0bib90","doi-asserted-by":"publisher","first-page":"982","DOI":"10.4103\/1673-5374.158365","type":"journal-article","article-title":"Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report","volume":"10","author":"Weiss","year":"2015","journal-title":"Neural Regen. Res."},{"key":"jneabb9c0bib91","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46188","type":"journal-article","article-title":"Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform","volume":"8","author":"Achberger","year":"2019","journal-title":"eLife"},{"key":"jneabb9c0bib92","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12015-018-9802-4","type":"journal-article","article-title":"Pluripotent stem cells for retinal tissue engineering: current status and future prospects","volume":"14","author":"Singh","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"jneabb9c0bib93","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.progpolymsci.2007.05.013","type":"journal-article","article-title":"Silk as a biomaterial","volume":"32","author":"Vepari","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"jneabb9c0bib94","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.actbio.2016.09.003","type":"journal-article","article-title":"Safety and tolerability of silk fibroin hydrogels implanted into the mouse brain","volume":"45","author":"Fern\u00e1ndez-Garc\u00eda","year":"2016","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib95","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1021\/acsbiomaterials.8b01024","type":"journal-article","article-title":"In vivo evaluation of engineered self-assembling silk fibroin hydrogels after intracerebral injection in a rat stroke model","volume":"5","author":"Gorenkova","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"jneabb9c0bib96","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3389\/fncel.2018.00296","type":"journal-article","article-title":"Cortical reshaping and functional recovery induced by silk fibroin hydrogels-encapsulated stem cells implanted in stroke animals","volume":"12","author":"Fern\u00e1ndez-Garc\u00eda","year":"2018","journal-title":"Frontiers Cell Neurosci."},{"key":"jneabb9c0bib97","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2019.02.052","type":"journal-article","article-title":"Film interface for drug testing for delivery to cells in culture and in the brain","volume":"94","author":"Tang-Schomer","year":"2019","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib98","doi-asserted-by":"publisher","first-page":"959","DOI":"10.4103\/1673-5374.268974","type":"journal-article","article-title":"Three-dimensional bioprinting collagen\/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury","volume":"15","author":"Jiang","year":"2020","journal-title":"Neural Regener. Res."},{"key":"jneabb9c0bib99","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110131","type":"journal-article","article-title":"Optimization of silk fibroin membranes for retinal implantation","volume":"105","author":"Suzuki","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"jneabb9c0bib100","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ejpb.2014.04.011","type":"journal-article","article-title":"A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles","volume":"88","author":"Huang","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"jneabb9c0bib101","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/ijms10041514","type":"journal-article","article-title":"Biodegradation of silk biomaterials","volume":"10","author":"Cao","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"jneabb9c0bib102","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jconrel.2014.05.059","type":"journal-article","article-title":"Silk-based biomaterials for sustained drug delivery","volume":"190","author":"Yucel","year":"2014","journal-title":"J. Controlled Release"},{"key":"jneabb9c0bib103","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.expneurol.2009.05.018","type":"journal-article","article-title":"Antiepileptic effects of silk-polymer based adenosine release in kindled rats","volume":"219","author":"Szybala","year":"2009","journal-title":"Exp. Neurol."},{"key":"jneabb9c0bib104","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.12659\/MSM.905569","type":"journal-article","article-title":"Isolation and culture of primary mouse retinal pigment epithelial (RPE) cells with rho-kinase and TGF\u03b2R-1\/ALK5 Inhibitor","volume":"23","author":"Shen","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"jneabb9c0bib105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124810","type":"journal-article","article-title":"Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa.","volume":"10","author":"Rocco","year":"2015","journal-title":"PLoS One"},{"key":"jneabb9c0bib106","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110131","type":"journal-article","article-title":"Optimization of silk fibroin membranes for retinal implantation","volume":"105","author":"Suzuki","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"jneabb9c0bib107","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/10837450.2018.1545236","type":"journal-article","article-title":"Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina","volume":"24","author":"Yang","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"jneabb9c0bib108","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3390\/jfb6030946","type":"journal-article","article-title":"Incorporation of human recombinant tropoelastin into silk fibroin membranes with the view to repairing bruch\u2019s membrane","volume":"6","author":"Shadforth","year":"2015","journal-title":"J. Funct. Biomater."},{"key":"jneabb9c0bib109","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nmat4874","type":"journal-article","article-title":"A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness","volume":"16","author":"Maya-Vetencourt","year":"2017","journal-title":"Nat. Mater."},{"key":"jneabb9c0bib110","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13287-020-01651-5","type":"journal-article","article-title":"Paracrine effects of intraocularly implanted cells on degenerating retinas in mice","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res Ther."},{"key":"jneabb9c0bib111","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nature05161","type":"journal-article","article-title":"Retinal repair by transplantation of photoreceptor precursors","volume":"444","author":"MacLaren","year":"2006","journal-title":"Nature"},{"key":"jneabb9c0bib112","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature10997","type":"journal-article","article-title":"Restoration of vision after transplantation of photoreceptors","volume":"485","author":"Pearson","year":"2012","journal-title":"Nature"},{"key":"jneabb9c0bib113","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/ijms18081406","type":"journal-article","article-title":"Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases","volume":"18","author":"Ding","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"jneabb9c0bib114","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1016\/j.biomaterials.2013.02.027","type":"journal-article","article-title":"Tissue engineering the retinal ganglion cell nerve fiber layer","volume":"34","author":"Kador","year":"2013","journal-title":"Biomaterials"},{"key":"jneabb9c0bib115","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/0896-6273(95)90172-8","type":"journal-article","article-title":"Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture","volume":"15","author":"Meyer-Franke","year":"1995","journal-title":"Neuron"},{"key":"jneabb9c0bib116","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1126\/science.1068428","type":"journal-article","article-title":"Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells","volume":"296","author":"Goldberg","year":"2002","journal-title":"Science"},{"key":"jneabb9c0bib117","doi-asserted-by":"publisher","first-page":"4939","DOI":"10.1016\/j.actbio.2014.08.032","type":"journal-article","article-title":"Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold","volume":"10","author":"Kador","year":"2014","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib118","doi-asserted-by":"publisher","first-page":"20540","DOI":"10.1021\/acsami.6b04679","type":"journal-article","article-title":"A self-assembling injectable biomimetic microenvironment encourages retinal ganglion cell axon extension in vitro","volume":"8","author":"Laughter","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"jneabb9c0bib119","first-page":"704","type":"journal-article","article-title":"Medical applications for 3D printing: current and projected uses","volume":"39","author":"Lee Ventola","year":"2014","journal-title":"Pharm. Ther."},{"key":"jneabb9c0bib120","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/S0266-3538(00)00241-4","type":"journal-article","article-title":"Biomedical applications of polymer-composite materials: A review","volume":"61","author":"Ramakrishna","year":"2001","journal-title":"Compos. Sci. Technol."},{"key":"jneabb9c0bib121","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.3390\/ijms18092013","type":"journal-article","article-title":"Elongation of axon extension for human iPSC-derived retinal ganglion cells by a nano-imprinted scaffold","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"jneabb9c0bib122","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.actbio.2010.12.031","type":"journal-article","article-title":"Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering","volume":"7","author":"Chen","year":"2011","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib123","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/(SICI)1097-4636(199824)43:4<422::AID-JBM9>3.0.CO;2-1","type":"journal-article","article-title":"Polymer concepts in tissue engineering","volume":"43","author":"Peter","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"jneabb9c0bib124","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701328","type":"journal-article","article-title":"Biomaterials for regenerative medicine approaches for the anterior segment of the eye","volume":"7","author":"Williams","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"jneabb9c0bib125","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0142-9612(02)00353-8","type":"journal-article","article-title":"Silk-based biomaterials","volume":"24","author":"Altman","year":"2003","journal-title":"Biomaterials"},{"key":"jneabb9c0bib126","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1016\/S0142-9612(02)00156-4","type":"journal-article","article-title":"Silk matrix for tissue engineered anterior cruciate ligaments","volume":"23","author":"Altman","year":"2002","journal-title":"Biomaterials"},{"key":"jneabb9c0bib127","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/bk-1994-0544.ch001","type":"journal-article","article-title":"Silk: Biology, Structure, Properties, and Genetics","volume":"544","author":"Kaplan","year":"1993"},{"key":"jneabb9c0bib128","doi-asserted-by":"publisher","first-page":"25-32","DOI":"10.1016\/S0141-3910(97)00000-1","type":"journal-article","article-title":"Fibrous proteins - Silk as a model system","volume":"59","author":"Kaplan","year":"1998","journal-title":"Polym. Degrad. Stab."},{"key":"jneabb9c0bib129","doi-asserted-by":"publisher","first-page":"6167","DOI":"10.1016\/j.biomaterials.2005.03.024","type":"journal-article","article-title":"Matrix-mediated retention of adipogenic differentiation potential by human adult bone marrow-derived mesenchymal stem cells during ex vivo expansion","volume":"26","author":"Mauney","year":"2005","journal-title":"Biomaterials"},{"key":"jneabb9c0bib130","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1089\/ten.2005.11.787","type":"journal-article","article-title":"Role of adult mesenchymal stem cells in bone tissue-engineering applications: current status and future prospects","volume":"11","author":"Mauney","year":"2005","journal-title":"Tissue Eng."},{"key":"jneabb9c0bib131","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.bone.2005.06.010","type":"journal-article","article-title":"Silk implants for the healing of critical size bone defects","volume":"37","author":"Meinel","year":"2005","journal-title":"Bone"},{"key":"jneabb9c0bib132","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/bit.20252","type":"journal-article","article-title":"Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds","volume":"88","author":"Meinel","year":"2004","journal-title":"Biotechnol. Bioeng."},{"key":"jneabb9c0bib133","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/jbm.a.30117","type":"journal-article","article-title":"Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds","volume":"71","author":"Meinel","year":"2004","journal-title":"J. Biomed. Mater. Res. A"},{"key":"jneabb9c0bib134","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.1016\/j.biomaterials.2007.09.001","type":"journal-article","article-title":"Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration","volume":"28","author":"Yang","year":"2007","journal-title":"Biomaterials"},{"key":"jneabb9c0bib135","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.biomaterials.2009.11.073","type":"journal-article","article-title":"Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration","volume":"31","author":"Madduri","year":"2010","journal-title":"Biomaterials"},{"key":"jneabb9c0bib136","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1002\/adfm.201190103","type":"journal-article","article-title":"Multifunctionalized electrospun silk fibers promote axon regeneration in the central nervous system","volume":"21","author":"Wittmer","year":"2011","journal-title":"Adv. Funct. Mater."},{"key":"jneabb9c0bib137","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.actbio.2017.02.032","type":"journal-article","article-title":"HiPSC-derived retinal ganglion cells grow dendritic arbors and functional axons on a tissue-engineered scaffold","volume":"54","author":"Li","year":"2017","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib138","doi-asserted-by":"publisher","first-page":"7622","DOI":"10.1016\/j.actbio.2013.04.048","type":"journal-article","article-title":"A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells","volume":"9","author":"Hertz","year":"2013","journal-title":"Acta Biomater."},{"key":"jneabb9c0bib139","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1016\/S0142-9612(00)00432-4","type":"journal-article","article-title":"Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation","volume":"22","author":"Chen","year":"2001","journal-title":"Biomaterials"},{"key":"jneabb9c0bib140","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10544-012-9687-y","type":"journal-article","article-title":"Structural and molecular micropatterning of dual hydrogel constructs for neural growth models using photochemical strategies","volume":"15","author":"Horn-Ranney","year":"2013","journal-title":"Biomed. Microdevices"},{"key":"jneabb9c0bib141","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1242\/dev.02412","type":"journal-article","article-title":"Growth cone navigation in substrate-bound ephrin gradients","volume":"133","author":"von Philipsborn","year":"2006","journal-title":"Development"},{"key":"jneabb9c0bib142","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12033-011-9411-9","type":"journal-article","article-title":"A novel method to produce immobilised biomolecular concentration gradients to study cell activities: design and modelling","volume":"50","author":"Vozzi","year":"2012","journal-title":"Mol. Biotechnol."},{"key":"jneabb9c0bib143","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1016\/j.biomaterials.2012.02.040","type":"journal-article","article-title":"The cultivation of human retinal pigment epithelial cells on Bombyx mori silk fibroin","volume":"33","author":"Shadforth","year":"2012","journal-title":"Biomaterials"},{"key":"jneabb9c0bib144","doi-asserted-by":"publisher","first-page":"8801","DOI":"10.1038\/s41598-019-45238-4","type":"journal-article","article-title":"Evaluation of neurosecretome from mesenchymal stem cells encapsulated in silk fibroin hydrogels","volume":"9","author":"Mart\u00edn-Mart\u00edn","year":"2019","journal-title":"Sci. Rep."},{"key":"jneabb9c0bib145","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/cells9051074","type":"journal-article","article-title":"Biomaterials to neuroprotect the stroke brain: a large opportunity for narrow time windows","volume":"9","author":"Gonz\u00e1lez-Nieto","year":"2020","journal-title":"Cells"},{"key":"jneabb9c0bib146","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1586\/eop.12.56","type":"journal-article","article-title":"Scaffolds and stem cells: delivery of cell transplants for retinal degenerations","volume":"7","author":"Kador","year":"2012","journal-title":"Expert Rev. Ophthalmol."},{"key":"jneabb9c0bib147","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1001\/archopht.123.12.1725","type":"journal-article","article-title":"Tissue bioengineering: potential applications to glaucoma","volume":"123","author":"Young","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"jneabb9c0bib148","doi-asserted-by":"publisher","DOI":"10.1201\/9781420003871","type":"book","article-title":"","author":"Yoon","year":"2006"},{"key":"jneabb9c0bib149","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12015-018-9802-4","type":"journal-article","article-title":"Pluripotent stem cells for retinal tissue engineering: current status and future prospects","volume":"14","author":"Singh","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"jneabb9c0bib150","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","type":"journal-article","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"jneabb9c0bib151","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0142-9612(02)00326-5","type":"journal-article","article-title":"Enzymatic degradation behavior of porous silk fibroin sheets","volume":"24","author":"Li","year":"2003","journal-title":"Biomaterials"},{"key":"jneabb9c0bib152","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.taap.2016.11.008","type":"journal-article","article-title":"A silk peptide fraction restores cognitive function in AF64A-induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene","volume":"314","author":"Cha","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Journal of Neural Engineering"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T13:18:15Z","timestamp":1768655895000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/abb9c0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":152,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,10,28]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1741-2552\/abb9c0","relation":{},"ISSN":["1741-2560","1741-2552"],"issn-type":[{"value":"1741-2560","type":"print"},{"value":"1741-2552","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]},"assertion":[{"value":"First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)","name":"article_title","label":"Article Title"},{"value":"Journal of Neural Engineering","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-02-29","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-18","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-10-28","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}