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Neural Eng."],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Retinal prostheses have been developed to restore vision in blind patients suffering from diseases like retinitis pigmentosa.\n                    <jats:italic>Approach.<\/jats:italic>\n                    A new type of retinal prosthesis called the Okayama University-type retinal prosthesis (OUReP) was developed by chemically coupling photoelectric dyes to a polyethylene film surface. The prosthesis works by passively generating an electric potential when stimulated by light. However, the neurophysiological mechanism of how OUReP stimulates the degenerated retina is unknown.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Here, we explore how the OUReP affects retinal tissues using a finite element model to solve for the potential inside the tissue and an active Hodgkin\u2013Huxley model based on rat vision to predict the corresponding retinal bipolar response.\n                    <jats:italic>Significance.<\/jats:italic>\n                    We show that the OUReP is likely capable of eliciting responses in retinal bipolar cells necessary to generate vision under most ambient conditions.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/abf892","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T23:26:07Z","timestamp":1618529167000},"page":"045006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film"],"prefix":"10.1088","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-0302","authenticated-orcid":false,"given":"Koichiro","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8871-1346","authenticated-orcid":false,"given":"Prathima","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-3054","authenticated-orcid":false,"given":"Tetsuya","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-0030","authenticated-orcid":false,"given":"Toshihiko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-3140","authenticated-orcid":false,"given":"Willy","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"jneabf892bib1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1001\/archopht.122.4.587","type":"journal-article","article-title":"Outer retinal degeneration: an electronic retinal prosthesis as a treatment strategy","volume":"122","author":"Loewenstein","year":"2004","journal-title":"Arch. 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