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Neural Eng."],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deep brain stimulation (DBS) using Medtronic\u2019s Percept\u2122 PC implantable pulse generator is FDA-approved for treating Parkinson\u2019s disease (PD), essential tremor, dystonia, obsessive compulsive disorder, and epilepsy. Percept\u2122 PC enables simultaneous recording of neural signals from the same lead used for stimulation. Many Percept\u2122 PC sensing features were built with PD patients in mind, but these features are potentially useful to refine therapies for many different disease processes. When starting our ongoing epilepsy research study, we found it difficult to find detailed descriptions about these features and have compiled information from multiple sources to understand it as a tool, particularly for use in patients other than those with PD. Here we provide a tutorial for scientists and physicians interested in using Percept\u2122 PC\u2019s features and provide examples of how neural time series data is often represented and saved. We address characteristics of the recorded signals and discuss Percept\u2122 PC hardware and software capabilities in data pre-processing, signal filtering, and DBS lead performance. We explain the power spectrum of the data and how it is shaped by the filter response of Percept\u2122 PC as well as the aliasing of the stimulation due to digitally sampling the data. We present Percept\u2122 PC\u2019s ability to extract biomarkers that may be used to optimize stimulation therapy. We show how differences in lead type affects noise characteristics of the implanted leads from seven epilepsy patients enrolled in our clinical trial. Percept\u2122 PC has sufficient signal-to-noise ratio, sampling capabilities, and stimulus artifact rejection for neural activity recording. Limitations in sampling rate, potential artifacts during stimulation, and shortening of battery life when monitoring neural activity at home were observed. Despite these limitations, Percept\u2122 PC demonstrates potential as a useful tool for recording neural activity in order to optimize stimulation therapies to personalize treatment.<\/jats:p>","DOI":"10.1088\/1741-2552\/ad1dc3","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T17:46:15Z","timestamp":1704995175000},"page":"012001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Neural signal data collection and analysis of Percept\u2122 PC BrainSense recordings for thalamic stimulation in epilepsy"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-1895","authenticated-orcid":true,"given":"Zachary T","family":"Sanger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-903X","authenticated-orcid":true,"given":"Thomas R","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-0811","authenticated-orcid":true,"given":"Michael C","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-0584","authenticated-orcid":true,"given":"David","family":"Darrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-1899","authenticated-orcid":true,"given":"Robert A","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-1930","authenticated-orcid":true,"given":"Theoden I","family":"Netoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"jnead1dc3bib1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00004691-200401000-00002","article-title":"Deep brain stimulation and essential tremor","volume":"21","author":"Lyons","year":"2004","journal-title":"J. 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