{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:34:57Z","timestamp":1783413297308,"version":"3.54.6"},"reference-count":27,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":27,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01EY013337"],"award-info":[{"award-number":["R01EY013337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Boswell Foundation"},{"name":"T&C Chen Brain-Machine Interface Center at Caltech"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    A crucial goal in brain\u2013machine interfacing is the long-term stability of neural decoding performance, ideally without regular retraining. Long-term stability has only been previously demonstrated in non-human primate experiments and only in primary sensorimotor cortices. Here we extend previous methods to determine long-term stability in humans by identifying and aligning low-dimensional structures in neural data.\n                    <jats:italic>Approach.<\/jats:italic>\n                    Over a period of 1106 and 871 d respectively, two participants completed an imagined center-out reaching task. The longitudinal accuracy between all day pairs was assessed by latent subspace alignment using principal components analysis and canonical correlations analysis of multi-unit intracortical recordings in different brain regions (Brodmann Area 5, Anterior Intraparietal Area and the junction of the postcentral and intraparietal sulcus).\n                    <jats:italic>Main results.<\/jats:italic>\n                    We show the long-term stable representation of neural activity in subspaces of intracortical recordings from higher-order association areas in humans.\n                    <jats:italic>Significance.<\/jats:italic>\n                    These results can be practically applied to significantly expand the longevity and generalizability of brain\u2013computer interfaces.\n                  <\/jats:p>\n                  <jats:p>Clinical Trials<\/jats:p>\n                  <jats:p>NCT01849822, NCT01958086, NCT01964261<\/jats:p>","DOI":"10.1088\/1741-2552\/ad6e19","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T18:51:31Z","timestamp":1723488691000},"page":"046059","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Neural subspaces of imagined movements in parietal cortex remain stable over several years in humans"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-2491","authenticated-orcid":true,"given":"L","family":"Bashford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-3820","authenticated-orcid":true,"given":"I A","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-1058","authenticated-orcid":true,"given":"S","family":"Kellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5916","authenticated-orcid":true,"given":"D","family":"Bj\u00e5nes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Pejsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-3466","authenticated-orcid":true,"given":"B W","family":"Brunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"jnead6e19bib1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1126\/science.aaa5417","article-title":"Decoding motor imagery from the posterior parietal cortex of a tetraplegic human","volume":"348","author":"Aflalo","year":"2015","journal-title":"Science"},{"key":"jnead6e19bib2","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nature04970","article-title":"Neuronal ensemble control of prosthetic devices by a human with tetraplegia","volume":"442","author":"Hochberg","year":"2006","journal-title":"Nature"},{"key":"jnead6e19bib3","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1152\/jn.90920.2008","article-title":"Single-unit stability using chronically implanted multielectrode arrays","volume":"102","author":"Dickey","year":"2009","journal-title":"J. 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