{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:25:08Z","timestamp":1793928308824,"version":"4.8.0"},"reference-count":39,"publisher":"IOP Publishing","issue":"6","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":18,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["L222033"],"award-info":[{"award-number":["L222033"]}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changping Laboratory"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective.<\/jats:italic> Current commercial magnetoencephalography (MEG) systems detect neuro-magnetic signals using superconducting quantum interference devices (SQUIDs), which require liquid helium as cryogen and have many limitations during operation. In contrast, optically pumped magnetometers (OPMs) technology provides a promising alternative to conventional SQUID-MEG. OPMs can operate at room temperature, offering benefits such as flexible deployment and lower costs. However, the validation of OPM-MEG has primarily been conducted on small sample sizes and specific regions of interest in the brain, lacking comprehensive validation for larger sample sizes and assessment of whole-brain. <jats:italic>Approach.<\/jats:italic> We recruited 100 participants, including healthy and neurological disorders individuals. Whole-brain OPM-MEG and SQUID-MEG data were recorded sequentially during auditory (<jats:italic>n<\/jats:italic> = 50) and visual (<jats:italic>n<\/jats:italic> = 50) stimulation experiments. By comparing the task-evoked responses of the two systems, we aimed to validate the performance of the next-generation OPM-MEG. <jats:italic>Main results.<\/jats:italic> The results showed that OPM-MEG enhanced the amplitude of task-related responses and exhibited similar magnetic field patterns and neural oscillatory activity as SQUID-MEG. There was no difference in the task-related latencies measured by the two systems. The signal-to-noise ratio was lower for the OPM-MEG in the auditory experiment, but did not differ in the visual experiment, suggesting that the results may be task-dependent. <jats:italic>Significance.<\/jats:italic> These results demonstrate that OPM-MEG, as an alternative to traditional SQUID-MEG, shows superior response amplitude and comparable performance in capturing brain dynamics. This study provides evidence for the effectiveness of OPM-MEG as a next-generation neuroimaging technique.<\/jats:p>","DOI":"10.1088\/1741-2552\/ad9680","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T22:48:02Z","timestamp":1732488482000},"page":"066033","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Performance of optically pumped magnetometer magnetoencephalography: validation in large samples and multiple tasks"],"prefix":"10.1088","volume":"21","author":[{"given":"Xiongfei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8511-6544","authenticated-orcid":true,"given":"Qiujian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1870-0852","authenticated-orcid":true,"given":"Yuying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-997X","authenticated-orcid":true,"given":"Jiangfen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-5020","authenticated-orcid":true,"given":"Jingwei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-0297","authenticated-orcid":true,"given":"Jia-Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"jnead9680bib1","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3390\/brainsci12060788","article-title":"A brief introduction to magnetoencephalography (MEG) and its clinical applications","volume":"12","author":"Fred","year":"2022","journal-title":"Brain Sci."},{"key":"jnead9680bib2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1103\/RevModPhys.65.413","article-title":"Magnetoencephalography\u2014theory, instrumentation, and applications to noninvasive studies of the working human brain","volume":"65","author":"H\u00e4m\u00e4l\u00e4inen","year":"1993","journal-title":"Rev. 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