{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:33:18Z","timestamp":1767691998615,"version":"3.48.0"},"reference-count":75,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018985","name":"Walloon Region","doi-asserted-by":"crossref","award":["Agreement N8191"],"award-info":[{"award-number":["Agreement N8191"]}],"id":[{"id":"10.13039\/100018985","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Epilepsy affects approximately 70 million individuals worldwide. Vagus nerve activity is known to be modulated by seizures; however, the types of fibers that are activated during seizures remain unknown. This work compares the electrical activity of the vagus nerve before, during, and after seizures in epileptic rats.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Six rats experiencing pentylenetetrazol-induced epilepsy seizures and two rats under saline solution were investigated. Action potentials (AP) identified by template matching were sorted according to the fiber type they are deemed to originate from. AP templates were based on a 3D COMSOL simplified model of the vagus nerve. Model templates were established for fibers of different diameters based on histology. Correspondences are thus established based on specific fiber diameters.\n                    <jats:italic>Main results<\/jats:italic>\n                    . During seizures, an increase in the percentage of occurrence of APs was observed for 2\n                    <jats:italic>\u03bc<\/jats:italic>\n                    m and 3\n                    <jats:italic>\u03bc<\/jats:italic>\n                    m fibers, while a decrease was observed for 4\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m, 5\u20136\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m, and 7\u201311\n                    <jats:italic>\u00b5<\/jats:italic>\n                    m fibers. This was not observed in the rat group under saline solution. The increase in smaller diameter sizes is believed to be linked to an increase in autonomic activity.\n                    <jats:italic>Significance<\/jats:italic>\n                    . These findings contribute to a better understanding of vagus nerve dynamics during epileptic seizures and highlight the potential of vagus nerve activity as a physiological marker for seizure detection and monitoring. This would be of particular interest in vagus nerve stimulation to control any closed-loop form of therapy. This work provides a foundation for developing novel diagnostic and therapeutic approaches in epilepsy management.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/ae30aa","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T22:50:16Z","timestamp":1766530216000},"page":"016002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of vagus nerve active fibers during seizure in rats"],"prefix":"10.1088","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-6701","authenticated-orcid":true,"given":"Javier","family":"Ch\u00e1vez Cerda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1034-2125","authenticated-orcid":false,"given":"Elena","family":"Acedo Reina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric","family":"Luppens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-2993","authenticated-orcid":true,"given":"Louis","family":"Vande Perre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-0367","authenticated-orcid":true,"given":"Romain","family":"Raffoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-6541","authenticated-orcid":true,"given":"Maxime","family":"Verstraeten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-187X","authenticated-orcid":true,"given":"Enrique","family":"Germany Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-6389","authenticated-orcid":true,"given":"Hugo","family":"Smets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3139-0080","authenticated-orcid":true,"given":"Pascal","family":"Doguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-3599","authenticated-orcid":true,"given":"Jean","family":"Delbeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-0194","authenticated-orcid":true,"given":"Ri\u00ebm","family":"El Tahry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-9588","authenticated-orcid":true,"given":"Antoine","family":"Nonclercq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"jneae30aabib1","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1212\/WNL.0b013e3182563b19","type":"journal-article","article-title":"Patterns of treatment response in newly diagnosed epilepsy","volume":"78","author":"Brodie","year":"2012","journal-title":"Neurology"},{"key":"jneae30aabib2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000503831","type":"journal-article","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"year":"2012","author":"Alarc\u00f3n","key":"jneae30aabib3","type":"book"},{"key":"jneae30aabib4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1528-1157.1997.tb01128.x","type":"journal-article","article-title":"Quality of life of people with epilepsy: a European study","volume":"38","author":"Baker","year":"1997","journal-title":"Epilepsia"},{"year":"2018","author":"Raedt","key":"jneae30aabib5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805353-9.00081-4","type":"book"},{"key":"jneae30aabib6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1056\/NEJM200002033420503","type":"journal-article","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"jneae30aabib7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1468-1331.2006.01215.x","type":"journal-article","article-title":"Diagnosing refractory epilepsy: response to sequential treatment schedules","volume":"13","author":"Mohanraj","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"jneae30aabib8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.eplepsyres.2007.06.003","type":"journal-article","article-title":"Predictors of pharmacoresistant epilepsy","volume":"75","author":"Hitiris","year":"2007","journal-title":"Epilepsy Res."},{"key":"jneae30aabib9","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1046\/j.1528-1157.2001.04501.x","type":"journal-article","article-title":"Effectiveness of first antiepileptic drug","volume":"42","author":"Kwan","year":"2001","journal-title":"Epilepsia"},{"key":"jneae30aabib10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2165\/00002018-199309030-00003","type":"journal-article","article-title":"Antiepileptic drugs: a review of clinically significant drug interactions","volume":"9","author":"Patsalos","year":"1993","journal-title":"Drug Saf."},{"key":"jneae30aabib11","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1017\/S0317167100040750","type":"journal-article","article-title":"Acute and chronic toxicity of antiepileptic medications: a selective review","volume":"21","author":"Camfield","year":"1994","journal-title":"J. Can. Des Sci. Neurol."},{"volume":"vol 83","year":"2013","author":"Engel","key":"jneae30aabib12","type":"book"},{"key":"jneae30aabib13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1227\/NEU.0000000000001165","type":"journal-article","article-title":"Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy","volume":"79","author":"Englot","year":"2016","journal-title":"Neurosurgery"},{"key":"jneae30aabib14","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1227\/NEU.0000000000000530","type":"journal-article","article-title":"Factors associated with failed focal neocortical epilepsy surgery","volume":"75","author":"Englot","year":"2014","journal-title":"Neurosurgery"},{"key":"jneae30aabib15","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3171\/2014.7.PEDS13658","type":"journal-article","article-title":"Epilepsy surgery failure in children: a quantitative and qualitative analysis","volume":"14","author":"Englot","year":"2014","journal-title":"J. Neurosurg. Pediatr."},{"key":"jneae30aabib16","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/S1474-4422(21)00300-8","type":"journal-article","article-title":"Neuromodulation in epilepsy: state-of-the-art approved therapies","volume":"20","author":"Ryvlin","year":"2021","journal-title":"Lancet Neurol."},{"key":"jneae30aabib17","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2021.696543","type":"journal-article","article-title":"Evolution of the vagus nerve stimulation (VNS) therapy system technology for drug-resistant epilepsy","volume":"3","author":"Afra","year":"2021","journal-title":"Front. Med. Technol."},{"key":"jneae30aabib18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0920-1211(03)00107-4","type":"journal-article","article-title":"Correlation between GABAA receptor density and vagus nerve stimulation in individuals with drug-resistant partial epilepsy","volume":"55","author":"Marrosu","year":"2003","journal-title":"Epilepsy Res."},{"key":"jneae30aabib19","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.790943","type":"journal-article","article-title":"How is the norepinephrine system involved in the antiepileptic effects of vagus nerve stimulation?","volume":"15","author":"Berger","year":"2021","journal-title":"Front. Neurosci."},{"key":"jneae30aabib20","doi-asserted-by":"publisher","first-page":"S255","DOI":"10.4103\/2152-7806.103015","type":"journal-article","article-title":"Vagus nerve stimulation for epilepsy: a review of central mechanisms","volume":"3","author":"Krahl","year":"2012","journal-title":"Surg. Neurol. Int."},{"key":"jneae30aabib21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.yebeh.2018.06.032","type":"journal-article","article-title":"Vagus nerve stimulation (VNS) therapy update","volume":"88","author":"Wheless","year":"2018","journal-title":"Epilepsy Behav."},{"key":"jneae30aabib22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/healthcare12010031","type":"journal-article","article-title":"Advances in non-invasive neuromodulation\u202f: designing closed-loop devices for respiratory-controlled transcutaneous vagus nerve stimulation","volume":"12","author":"De Faria","year":"2024","journal-title":"Healthcare"},{"key":"jneae30aabib23","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1212\/WNL.53.8.1731","type":"journal-article","article-title":"Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy","volume":"53","author":"Morris","year":"1999","journal-title":"Neurology"},{"key":"jneae30aabib24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/00004691-200109000-00005","type":"journal-article","article-title":"Vagus nerve stimulation, side effects, and long-term safety","volume":"18","author":"Ben-Menachem","year":"2001","journal-title":"J. Clin. Neurophysiol."},{"key":"jneae30aabib25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.expneurol.2011.04.014","type":"journal-article","article-title":"Animal models for vagus nerve stimulation in epilepsy","volume":"230","author":"Aalbers","year":"2011","journal-title":"Exp. Neurol."},{"key":"jneae30aabib26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.seizure.2021.03.030","type":"journal-article","article-title":"Closed-loop vagal nerve stimulation for intractable epilepsy: a single-center experience","volume":"88","author":"Winston","year":"2021","journal-title":"Seizure"},{"key":"jneae30aabib27","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.seizure.2014.02.012","type":"journal-article","article-title":"Ictal tachycardia: the head-heart connection","volume":"23","author":"Eggleston","year":"2014","journal-title":"Seizure"},{"key":"jneae30aabib28","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/ner.12376","type":"journal-article","article-title":"Automatic vagus nerve stimulation triggered by ictal tachycardia: clinical outcomes and device performance\u2014The U.S. E-37 trial","volume":"19","author":"Fisher","year":"2016","journal-title":"Neuromodulation"},{"key":"jneae30aabib29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.seizure.2015.02.004","type":"journal-article","article-title":"Cardiac-based vagus nerve stimulation reduced seizure duration in a patient with refractory epilepsy","volume":"26","author":"Hampel","year":"2015","journal-title":"Seizure"},{"key":"jneae30aabib30","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065721500246","type":"journal-article","article-title":"Vagus nerve electroneurogram-based detection of acute pentylenetetrazol induced seizures in rats","volume":"31","author":"Stumpp","year":"2021","journal-title":"Int. J. Neural Syst."},{"key":"jneae30aabib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/MeMeA60663.2024.10596789","type":"conference-proceedings","article-title":"Proof-of-concept of respiration-triggered vagus nerve stimulation to treat epilepsy","author":"Ch\u00e1vez Cerda","year":"2024"},{"key":"jneae30aabib32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1109\/BioCAS54905.2022.9948638","type":"conference-proceedings","article-title":"Micro cuff electrode manufacture for vagus nerve monitoring in rats","author":"Ch\u00e1vez Cerda","year":"2022"},{"key":"jneae30aabib33","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s11517-011-0782-7","type":"journal-article","article-title":"Ictal and peri-ictal changes in cervical vagus nerve activity associated with cardiac effects","volume":"49","author":"Harreby","year":"2011","journal-title":"Med. Biol. Eng. Comput."},{"key":"jneae30aabib34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108832","type":"journal-article","article-title":"Recording of spontaneous vagus nerve activity during pentylenetetrazol-induced seizures in rats","volume":"343","author":"Stumpp","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"jneae30aabib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2024.1427308","type":"journal-article","article-title":"Vagus nerve electroneurogram-based detection of acute kainic acid induced seizures","volume":"18","author":"Acedo Reina","year":"2024","journal-title":"Front. Neurosci."},{"key":"jneae30aabib36","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.seizure.2012.03.011","type":"journal-article","article-title":"Parasympathetic alteration during sub-clinical seizures","volume":"21","author":"Brotherstone","year":"2012","journal-title":"Seizure"},{"key":"jneae30aabib37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/epi.12614","type":"journal-article","article-title":"Heart rate variability analysis indicates preictal parasympathetic overdrive preceding seizure\u2010induced cardiac dysrhythmias leading to sudden unexpected death in a patient with epilepsy","volume":"55","author":"Jeppesen","year":"2014","journal-title":"Epilepsia"},{"key":"jneae30aabib38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s42234-022-00091-1","type":"journal-article","article-title":"Strategies for precision vagus neuromodulation","volume":"8","author":"Ahmed","year":"2022","journal-title":"Bioelectron. Med."},{"key":"jneae30aabib39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fnins.2020.00284","type":"journal-article","article-title":"Critical review of transcutaneous vagus nerve stimulation: challenges for translation to clinical practice","volume":"14","author":"Yap","year":"2020","journal-title":"Front. Neurosci."},{"key":"jneae30aabib40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/ar.1091310404","type":"journal-article","article-title":"The myelinated component of the vagus nerves in man","volume":"131","author":"Schnitzlein","year":"1958","journal-title":"Anat. Rec."},{"key":"jneae30aabib41","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1109\/BioCAS54905.2022.9948681","type":"conference-proceedings","article-title":"Action potential detection algorithm adaptable to individual nerve and recording setup","author":"Raffoul","year":"2022"},{"key":"jneae30aabib42","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abe68f","type":"journal-article","article-title":"Analysing vagus nerve spontaneous activity using finite element modelling","volume":"18","author":"Smets","year":"2021","journal-title":"J. Neural Eng."},{"key":"jneae30aabib43","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1487082","type":"journal-article","article-title":"The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol","volume":"19","author":"Ch\u00e1vez Cerda","year":"2025","journal-title":"Front. Neurosci."},{"key":"jneae30aabib44","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/BF00374660","type":"journal-article","article-title":"Action potentials and membrane currents in the human node of Ranvier","volume":"430","author":"Schwarz","year":"1995","journal-title":"Pflugers Arch."},{"key":"jneae30aabib45","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/BF02513291","type":"journal-article","article-title":"A model of the electrical behaviour of myelinated sensory nerve fibres based on human data","volume":"37","author":"Wesselink","year":"1999","journal-title":"Med. Biol. Eng. Comput."},{"key":"jneae30aabib46","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.brainres.2007.12.045","type":"journal-article","article-title":"Morphology and morphometry of the vagus nerve in male and female spontaneously hypertensive rats","volume":"1197","author":"Licursi de Alc\u00e2ntara","year":"2008","journal-title":"Brain Res."},{"key":"jneae30aabib47","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1109\/TBME.1976.324593","type":"journal-article","article-title":"Analysis of a model for excitation of myelinated nerve","volume":"BME-23","author":"McNeal","year":"1976","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"jneae30aabib48","doi-asserted-by":"publisher","first-page":"e7754","DOI":"10.1371\/journal.pone.0007754","type":"journal-article","article-title":"What is the optimal value of the g-ratio for myelinated fibers in the rat CNS? A theoretical approach","volume":"4","author":"Chomiak","year":"2009","journal-title":"PLoS One"},{"key":"jneae30aabib49","first-page":"1577","type":"conference-proceedings","article-title":"Modeling of mammalian myelinated nerve for functional neuromuscular stimulation","author":"Sweeney","year":"1987"},{"key":"jneae30aabib50","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.eplepsyres.2016.07.009","type":"journal-article","article-title":"Investigation of mechanisms of vagus nerve stimulation for seizure using finite element modeling","volume":"126","author":"Arle","year":"2016","journal-title":"Epilepsy Res."},{"key":"jneae30aabib51","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1540-8159.1991.tb04053.x","type":"journal-article","article-title":"Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording","volume":"14","author":"Woodbury","year":"1991","journal-title":"Pacing Clin. Electrophysiol."},{"key":"jneae30aabib52","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1109\/NER.2019.8717121","type":"journal-article","article-title":"Modeling the recording of intraneural action potentials with microelectrodes using fem and point-source methods","volume":"2019","author":"Furniturewalla","year":"2019","journal-title":"Int. IEEE\/EMBS Conf. Neural Eng. NER"},{"key":"jneae30aabib53","first-page":"1","type":"journal-article","article-title":"Kruskal-wallis test","author":"McKight","year":"2010","journal-title":"Corsini Encycl. Psychol."},{"key":"jneae30aabib54","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","type":"journal-article","article-title":"A multiple comparison procedure for comparing several treatments with a control","volume":"50","author":"Dunnett","year":"1955","journal-title":"J. Am. Stat. Assoc."},{"key":"jneae30aabib55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nmo.13889","type":"journal-article","article-title":"Comparison between the cervical and abdominal vagus nerves in mice, pigs, and humans","volume":"32","author":"Stakenborg","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"jneae30aabib56","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.brainres.2018.02.003","type":"journal-article","article-title":"Effects of vagal neuromodulation on feeding behavior","volume":"1693","author":"Pelot","year":"2018","journal-title":"Brain Res."},{"key":"jneae30aabib57","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1113\/jphysiol.1957.sp005703","type":"journal-article","article-title":"Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat","volume":"135","author":"Agostoni","year":"1957","journal-title":"J. Physiol."},{"key":"jneae30aabib58","first-page":"320","type":"journal-article","article-title":"Histological and functional studies on the fibre composition of the vagus nerve of the rabbit","volume":"88","author":"Evans","year":"1954","journal-title":"J. Anat."},{"key":"jneae30aabib59","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF00389602","type":"journal-article","article-title":"An electron microscope study of vagus nerve composition in the ferret","volume":"175","author":"Asala","year":"1986","journal-title":"Anat. Embryol."},{"key":"jneae30aabib60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2020.601479","type":"journal-article","article-title":"Quantified morphology of the cervical and subdiaphragmatic vagus nerves of human, pig, and rat","volume":"14","author":"Pelot","year":"2020","journal-title":"Front. Neurosci."},{"key":"jneae30aabib61","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neulet.2009.05.064","type":"journal-article","article-title":"Microneurographic single-unit recordings to assess receptive properties of afferent human C-fibers","volume":"470","author":"Schmelz","year":"2010","journal-title":"Neurosci. Lett."},{"key":"jneae30aabib62","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/bimj.4710380510","type":"journal-article","article-title":"Estimation of the power of the Kruskal-Wallis test","volume":"38","author":"Mahoney","year":"1996","journal-title":"Biom. J."},{"key":"jneae30aabib63","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1152\/jn.00353.2001","type":"journal-article","article-title":"Modeling the excitability of mammalian nerve fibers: influence of after potentials on the recovery cycle","volume":"87","author":"McIntyre","year":"2002","journal-title":"J. Neurophysiol."},{"key":"jneae30aabib64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s42234-025-00174-9","type":"journal-article","article-title":"Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species","volume":"11","author":"Musselman","year":"2025","journal-title":"Bioelectron. Med."},{"key":"jneae30aabib65","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aaeb0c","type":"journal-article","article-title":"On the parameters used in finite element modeling of compound peripheral nerves","volume":"16","author":"Pelot","year":"2018","journal-title":"J. Neural Eng."},{"key":"jneae30aabib66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s44328-024-00012-z","type":"journal-article","article-title":"Label-free functional imaging of vagus nerve stimulation-evoked potentials at the cortical surface","volume":"1","author":"RoaFiore","year":"2024","journal-title":"npj Biosensing"},{"key":"jneae30aabib67","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0165-0270(02)00304-7","type":"journal-article","article-title":"Detection of single unit activity from the rat vagus using cluster analysis of principal components","volume":"122","author":"Horn","year":"2003","journal-title":"J. Neurosci. Methods"},{"key":"jneae30aabib68","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.clinph.2020.12.009","type":"journal-article","article-title":"Automated seizure detection using wearable devices: a clinical practice guideline of the international league against epilepsy and the international federation of clinical neurophysiology","volume":"132","author":"Beniczky","year":"2021","journal-title":"Clin. Neurophysiol."},{"key":"jneae30aabib69","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3390\/jcm14030863","type":"journal-article","article-title":"Seizure detection devices","volume":"14","author":"Baumgartner","year":"2025","journal-title":"J. Clin. Med."},{"key":"jneae30aabib70","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1568261","type":"journal-article","article-title":"Vagal nerve signals are modulated by spontaneous seizures in genetic absence epilepsy rats from Strasbourg","volume":"19","author":"Collard","year":"2025","journal-title":"Front. Neurosci."},{"key":"jneae30aabib71","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac7c8f","type":"journal-article","article-title":"Chronic recording of the vagus nerve to analyze modulations by the light\u2013dark cycle","volume":"19","author":"Smets","year":"2022","journal-title":"J. Neural Eng."},{"key":"jneae30aabib72","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1109\/BioCAS54905.2022.9948636","type":"conference-proceedings","article-title":"Chronic setup system for continuous monitoring of epileptic rats","author":"Ch\u00e1vez Cerda","year":"2022"},{"key":"jneae30aabib73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneur.2017.00588","type":"journal-article","article-title":"Kainic acid-induced post-status epilepticus models of temporal lobe epilepsy with diverging seizure phenotype and neuropathology","volume":"8","author":"Bertoglio","year":"2017","journal-title":"Front. Neurol."},{"key":"jneae30aabib74","doi-asserted-by":"crossref","DOI":"10.1109\/IEMBS.2004.1403654","type":"conference-proceedings","article-title":"Reduction of power line interference using active electrodes and a driven-right-leg circuit in electroencephalographic recording with a minimum number of electrodes","author":"Nonclercq","year":"2004"},{"key":"jneae30aabib75","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1109\/TBME.2010.2055867","type":"journal-article","article-title":"Quantification of motion artifact rejection due to active electrodes and driven-right-leg circuit in spike detection algorithms","volume":"57","author":"Nonclercq","year":"2010","journal-title":"IEEE Trans. Biomed. Eng."}],"container-title":["Journal of Neural Engineering"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:31:02Z","timestamp":1767691862000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/ae30aa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,6]]},"published-print":{"date-parts":[[2026,2,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1741-2552\/ae30aa","relation":{},"ISSN":["1741-2560","1741-2552"],"issn-type":[{"type":"print","value":"1741-2560"},{"type":"electronic","value":"1741-2552"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"Characterization of vagus nerve active fibers during seizure in rats","name":"article_title","label":"Article Title"},{"value":"Journal of Neural Engineering","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-12-18","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-12-23","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-06","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}