{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:40Z","timestamp":1777983880109,"version":"3.51.4"},"reference-count":49,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100008795","name":"Manitoba Medical Service Foundation","doi-asserted-by":"crossref","award":["2025-03"],"award-info":[{"award-number":["2025-03"]}],"id":[{"id":"10.13039\/100008795","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"crossref","award":["RGPIN-2023-03443"],"award-info":[{"award-number":["RGPIN-2023-03443"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    This study investigates whether dynamic functional connectivity (dFC) dwell-time patterns derived from resting-state functional magnetic resonance imaging (rs-fMRI) can distinguish Alzheimer\u2019s disease (AD) genetic risk profiles, specifically the APOE-\n                    <jats:inline-formula>\n                      <jats:tex-math>\n                        \n                      <\/jats:tex-math>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                        <mml:mrow>\n                          <mml:mi>\u03b5<\/mml:mi>\n                          <mml:mn>4<\/mml:mn>\n                        <\/mml:mrow>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    (A+) and phosphatidylinositol-binding clathrin assembly protein rs3851179 (P+) variants, in cognitively healthy, middle-aged adults.\n                    <jats:italic>Approach.<\/jats:italic>\n                    We estimated recurring dFC clusters from rs-fMRI data and quantified the dwell-time (total duration spent in specific connectivity states) for three cohorts: not-at-risk, A+P\u2212, and A+P+. To evaluate the utility of these temporal features, group differences in dwell-time profiles were assessed, and logistic regression with permutation testing was employed to classify genotypes based on dFC patterns.\n                    <jats:italic>Main results.<\/jats:italic>\n                    Individuals in at-risk groups (A+P\u2212 and A+P+) exhibited significantly reduced dwell-time in left-hemisphere hubs compared to the not-at-risk group, aligning with known left-hemisphere vulnerability in early AD progression. The logistic regression models achieved above-chance discrimination of genotypes, with permutation tests confirming a significant trend when distinguishing not-at-risk individuals from the combined at-risk cohorts.\n                    <jats:italic>Significance.<\/jats:italic>\n                    These findings suggest that the temporal dFC features are sensitive to subtle functional brain alterations linked to AD genetic risk before clinical symptoms appear. Dwell-time features represent a promising physiological marker for early risk stratification and warrant further validation in larger longitudinal datasets. Our code is available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/Shyamal-Dharia\/APOE-PICALM-dFC-dwell-time.git\">https:\/\/github.com\/Shyamal-Dharia\/APOE-PICALM-dFC-dwell-time.git<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/ae4926","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:50:09Z","timestamp":1771887009000},"page":"026016","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the interaction of APOE-\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>\u03b5<\/mml:mi>\n                        <mml:mn>4<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    and PICALM rs3851179 with dynamic functional connectivity in healthy middle-aged adults at risk for Alzheimer\u2019s disease"],"prefix":"10.1088","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1956-8726","authenticated-orcid":true,"given":"Shyamal Y","family":"Dharia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-8265","authenticated-orcid":true,"given":"Camilo E","family":"Valderrama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9832-596X","authenticated-orcid":true,"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-8372","authenticated-orcid":false,"given":"Stephen D","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"jneae4926bib1","first-page":"36","type":"journal-article","article-title":"Preclinical, prodromal and dementia stages of Alzheimer\u2019s disease","volume":"15","author":"Scharre","year":"2019","journal-title":"Pract. 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