{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:35:39Z","timestamp":1780403739389,"version":"3.54.1"},"reference-count":56,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":6,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"Cleveland Clinic Neurological Institute Transformative Research Grant"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Epilepsy is characterized by dynamic disruptions in brain networks, yet the spatiotemporal organization of directional interactions underlying ictal transitions remains incompletely understood. This study investigates peri-ictal transition patterns in mesial temporal lobe epilepsy (MTLE) by characterizing directional connectivity dynamics from intracranial stereo-electroencephalography (SEEG) seizure recordings.\n                    <jats:italic>Approach<\/jats:italic>\n                    . We analyzed SEEG data from 10 patients with MTLE who subsequently achieved seizure freedom following surgical resection. We quantified directional connectivity using directed transfer function measures across preictal, ictal, and post-ictal phases. We then applied clustering analyses to identify reproducible dynamical connectivity patterns and evaluated their consistency across seizures and patients.\n                    <jats:italic>Main results<\/jats:italic>\n                    . We identified distinct out-degree connectivity patterns across seizure phases, each associated with specific anatomical regions. Regions corresponding to the epileptogenic zone exhibited elevated out-degree during the preictal and early ictal periods, whereas non-resected regions showed increased out-degree during ictal termination and postictal phases. These patterns remained consistent across patients and seizures, demonstrating a structured and phase-dependent organization of directional information flow during seizure evolution.\n                    <jats:italic>Significance<\/jats:italic>\n                    . This study identifies stereotypical and reproducible peri-ictal directional connectivity patterns in MTLE. By characterizing how information flow evolves across seizure phases, our findings advance network-level understanding of ictal transitions and provide a reproducible framework for future studies of seizure network dynamics.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/ae555c","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:50:57Z","timestamp":1774047057000},"page":"026026","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Directional connectivity patterns in SEEG recorded epileptiform transitions in mesial temporal lobe epilepsy"],"prefix":"10.1088","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-7103","authenticated-orcid":true,"given":"Hanu Skanda","family":"Banappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1847-4049","authenticated-orcid":false,"given":"Tassia Ribeiro Salles","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-9705","authenticated-orcid":true,"given":"Demitre","family":"Serletis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-3286","authenticated-orcid":false,"given":"Andreas","family":"Alexopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-518X","authenticated-orcid":false,"given":"Juan","family":"Bulacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-3359","authenticated-orcid":true,"given":"Balu","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"jneae555cbib1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","type":"journal-article","article-title":"Neural networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"key":"jneae555cbib2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/epi.17171","type":"journal-article","article-title":"Epilepsy and brain network hubs","volume":"63","author":"Royer","year":"2022","journal-title":"Epilepsia"},{"key":"jneae555cbib3","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/epi.12152","type":"journal-article","article-title":"Temporal patterns and mechanisms of epilepsy surgery failure","volume":"54","author":"Najm","year":"2013","journal-title":"Epilepsia"},{"key":"jneae555cbib4","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1056\/NEJMoa1615335","type":"journal-article","article-title":"Surgery for drug-resistant epilepsy in children","volume":"377","author":"Dwivedi","year":"2017","journal-title":"N. 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