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Neural Eng."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Aberrant nonlinear dynamics of hippocampal neural oscillations are a hallmark of early network dysfunction in Alzheimer\u2019s disease (AD), with critical roles in memory processing. Although transcranial ultrasound stimulation (TUS) has shown cognitive benefits in AD models and patients, its effects on the nonlinear dynamics of hippocampal CA1 oscillations and their multiscale organization remain unclear.\n                    <jats:italic>Approach.<\/jats:italic>\n                    Here, we applied 40 Hz noninvasive TUS to the hippocampal CA1 region of AD mouse model and recorded local field potentials before, during, and after stimulation. Analyses integrated nonlinear dynamical metrics, power spectral dependencies, cross-frequency coupling, and event-level oscillatory features.\n                    <jats:italic>Main results.<\/jats:italic>\n                    We found that (1) 40 Hz TUS decreases complexity and irregularity of CA1 activity, and enhances dynamical activity and long-range temporal correlations in broadband and high-frequency ranges, increases complexity in the theta and beta bands. (2) TUS also significantly reduced theta\u2013gamma and intra-gamma phase-amplitude coupling, while producing frequency-specific changes in the rate, amplitude, duration, and temporal organization of theta, gamma, and ripple events. (3) Furthermore, the relationship between nonlinear dynamics and power spectral density was modulated across stimulation phases.\n                    <jats:italic>Significance.<\/jats:italic>\n                    40 Hz TUS can modulate multiscale nonlinear dynamics of neural oscillations in hippocampal CA1 of Alzheimer\u2019s mouse model, which lays a theoretical foundation for the clinical intervention of AD via ultrasound stimulation.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/ae9eed","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:50:33Z","timestamp":1787784633000},"page":"056015","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["40 Hz noninvasive transcranial ultrasound stimulation modulates multiscale nonlinear dynamics of hippocampal CA1 neural oscillations of Alzheimer\u2019s mouse model"],"prefix":"10.1088","volume":"23","author":[{"given":"Jiamin","family":"Chen","sequence":"first","affiliation":[{"name":"Yanshan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-6677","authenticated-orcid":true,"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Yanshan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"jneae9eedbib1","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1126\/science.1099745","type":"journal-article","article-title":"Neuronal oscillations in cortical networks","volume":"304","author":"Buzs\u00e1ki","year":"2004","journal-title":"Science"},{"key":"jneae9eedbib2","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/nn.4661","type":"journal-article","article-title":"Viewpoints: how the hippocampus contributes to memory, navigation and cognition","volume":"20","author":"Lisman","year":"2017","journal-title":"Nat. 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