{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T07:35:39Z","timestamp":1793000139385,"version":"4.5.0"},"reference-count":121,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:00:00Z","timestamp":1792972800000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:00:00Z","timestamp":1792972800000},"content-version":"tdm","delay-in-days":25,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Canadian Institutes of Health Research","award":["CGS-D - 476621"],"award-info":[{"award-number":["CGS-D - 476621"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Natural Sciences and Engineering Research Council of Canada","award":["RGPIN\/03713"],"award-info":[{"award-number":["RGPIN\/03713"]}],"id":[{"id":"https:\/\/ror.org\/01h531d29","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Neural Eng."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Peripheral nerve regeneration is regulated by structural, biochemical, and electrical cues, yet their combined effects on neurite outgrowth remain unclear. In this study, an aligned fibrous scaffold was developed to evaluate how extracellular matrix (ECM) composition and electrical stimulation influence neurite extension and growth cone morphology.\n                    <jats:italic>Approach<\/jats:italic>\n                    . Type I collagen fibers incorporating fibronectin, collagen IV, and laminin I were fabricated by contact drawing. The contact drawn fibers were then consolidated into multifilaments, which were mounted on custom frames for cell culture. Primary dorsal root ganglia (DRG) explants were cultured on the multifilaments, and neurite outgrowth and alignment were quantified as a function of ECM composition. Functional activity was confirmed by patch clamp. High-resolution confocal imaging was performed to assess cytoskeletal organization and growth cone morphology. Electrical stimulation was applied to evaluate interactions between biochemical and bioelectrical cues.\n                    <jats:italic>Main Results<\/jats:italic>\n                    . Collagen multifilament scaffolds promoted a high degree of neurite alignment relative to DRGs cultured on isotropic surfaces. Fibronectin and collagen IV increased neurite length in a concentration-dependent manner, with maximal effects observed at intermediate ligand densities, while laminin I had no significant effect. Combinatorial ECM presentation produced non-additive responses. Electrical stimulation increased neurite length on collagen-only scaffolds but had a reduced effect or no effect with incorporation of additional ECM constituents. Growth cone morphology was altered by ECM composition, with fibronectin-, collagen IV-, and combinatorial scaffolds producing less circular growth cones, despite no significant differences in filopodia number or overall morphology-classification proportions.\n                    <jats:italic>Significance<\/jats:italic>\n                    . Neurite extension and growth cone structure are governed by non-linear interactions between multimodal cues. The scaffold system described here facilitates systematic comparison of multiple regenerative cues to inform the design of material for promoting nerve regeneration.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/aeb32c","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:50:34Z","timestamp":1791845434000},"page":"056060","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodal regulation of neurite extension by extracellular matrix composition and electrical stimulation on aligned collagen fiber scaffolds"],"prefix":"10.1088","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-6895","authenticated-orcid":true,"given":"Madalynn J","family":"Thompson","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1077-1151","authenticated-orcid":true,"given":"Joanna","family":"Borowska-Fielding","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7708-9509","authenticated-orcid":true,"given":"Ivy A","family":"Murphy","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-5666","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Victor","family":"Rafuse","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-1147","authenticated-orcid":true,"given":"John P","family":"Frampton","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Dalhousie University"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,10,26]]},"reference":[{"key":"jneaeb32cbib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2009.12.001","type":"journal-article","article-title":"Introduction to special issue: challenges and opportunities for regeneration in the peripheral nervous system","volume":"223","author":"H\u00f6ke","year":"2010","journal-title":"Exp. Neurol."},{"key":"jneaeb32cbib2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/brain\/74.4.491","type":"journal-article","article-title":"Classification of peripheral nerve injuries producing loss of function","volume":"74","author":"Sunderland","year":"1951","journal-title":"Brain"},{"key":"jneaeb32cbib3","article-title":"Nerve injuries and their repair: a critical appraisal","author":"Sunderland","year":"1991","type":"book"},{"key":"jneaeb32cbib4","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1330224","type":"journal-article","article-title":"Advancements in autologous peripheral nerve transplantation care: a review of strategies and practices to facilitate recovery","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Neurol."},{"key":"jneaeb32cbib5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev.bioeng.5.011303.120731","type":"journal-article","article-title":"Neural tissue engineering: strategies for repair and regeneration","volume":"5","author":"Schmidt","year":"2003","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"jneaeb32cbib6","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.biomaterials.2007.11.036","type":"journal-article","article-title":"Peripheral nerve regeneration within an asymmetrically porous PLGA\/Pluronic F127 nerve guide conduit","volume":"29","author":"Oh","year":"2008","journal-title":"Biomaterials"},{"key":"jneaeb32cbib7","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.2106\/jbjs.l.00704","type":"journal-article","article-title":"Peripheral nerve repair and reconstruction","volume":"95","author":"Griffin","year":"2013","journal-title":"J. Bone Joint Surg. Am."},{"key":"jneaeb32cbib8","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202402062","type":"journal-article","article-title":"Bioengineered models of nerve regeneration","volume":"10","author":"Thompson","year":"2025","journal-title":"Adv. Mater. Technol."},{"key":"jneaeb32cbib9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.conb.2006.08.005","type":"journal-article","article-title":"Basal lamina: Schwann cells wrap to the rhythm of space-time","volume":"16","author":"Court","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"jneaeb32cbib10","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1073\/pnas.80.12.3850","type":"journal-article","article-title":"In vivo and in vitro observations on laminin production by Schwann cells","volume":"80","author":"Cornbrooks","year":"1983","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"jneaeb32cbib11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1083\/jcb.97.2.473","type":"journal-article","article-title":"Biosynthesis of type IV collagen by cultured rat Schwann cells","volume":"97","author":"Carey","year":"1983","journal-title":"J. Cell Biol."},{"key":"jneaeb32cbib12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/bf02057903","type":"journal-article","article-title":"Basal lamina-associated heparan sulphate proteoglycan in the rat PNS: characterization and localization using monoclonal antibodies","volume":"15","author":"Eldridge","year":"1986","journal-title":"J. Neurocytol."},{"key":"jneaeb32cbib13","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1679\/aohc.49.553","type":"journal-article","article-title":"Three-dimensional architecture of the endoneurium with special reference to the collagen fibril arrangement in relation to nerve fibers","volume":"49","author":"Ushiki","year":"1986","journal-title":"Arch Histol Jpn"},{"key":"jneaeb32cbib14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","type":"journal-article","article-title":"Peripheral regeneration","volume":"30","author":"Chen","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"jneaeb32cbib15","doi-asserted-by":"publisher","first-page":"28208","DOI":"10.1074\/jbc.M003922200","type":"journal-article","article-title":"Schwann cells synthesize type V collagen that contains a novel a4 Chain","volume":"275","author":"Chernousov","year":"2000","journal-title":"J. Biol. Chem."},{"key":"jneaeb32cbib16","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1515\/revneuro-2013-0022","type":"journal-article","article-title":"The role of peripheral nerve ECM components in the tissue engineering nerve construction","volume":"24","author":"Gao","year":"2013","journal-title":"Rev. Neurosci."},{"key":"jneaeb32cbib17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/ATN.ATN-D-23-00005","type":"journal-article","article-title":"Recent advances in biomaterial design for nerve guidance conduits: a narrative review","volume":"1","author":"Amalakanti","year":"2024","journal-title":"Ovid"},{"key":"jneaeb32cbib18","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.973301","type":"journal-article","article-title":"The application of collagen in the repair of peripheral nerve defect","volume":"10","author":"Li","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"jneaeb32cbib19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.expneurol.2003.10.016","type":"journal-article","article-title":"CNS stem and progenitor cell differentiation into functional neuronal circuits in three-dimensional collagen gels","volume":"190","author":"Ma","year":"2004","journal-title":"Exp. Neurol."},{"key":"jneaeb32cbib20","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1089\/ten.tea.2009.0381","type":"journal-article","article-title":"Cell-laden hydrogel constructs of hyaluronic acid, collagen, and laminin for neural tissue engineering","volume":"16","author":"Suri","year":"2010","journal-title":"Tissue Eng. A"},{"key":"jneaeb32cbib21","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1021\/acsabm.1c01138","type":"journal-article","article-title":"Type\u2010I collagen\/collagenase modulates the 3D structure and behavior of glioblastoma spheroid models","volume":"5","author":"Calori","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"jneaeb32cbib22","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.injury.2010.12.030","type":"journal-article","article-title":"FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy","volume":"43","author":"Kehoe","year":"2012","journal-title":"Injury"},{"key":"jneaeb32cbib23","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1089\/ten.teb.2009.0639","type":"journal-article","article-title":"Controlling the porosity and microarchitecture of hydrogels for tissue engineering","volume":"16","author":"Annabi","year":"2010","journal-title":"Tissue Eng. B"},{"key":"jneaeb32cbib24","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/polym9120638","type":"journal-article","article-title":"Novel human-like collagen hydrogel scaffold with porous structure and sponge-like properties","volume":"9","author":"Song","year":"2017","journal-title":"Polymers"},{"key":"jneaeb32cbib25","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.644595","type":"journal-article","article-title":"Mimicking the hierarchical organization of natural collagen: toward the development of ideal scaffolding material for tissue regeneration","volume":"9","author":"Salvatore","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"jneaeb32cbib26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.actbio.2017.10.035","type":"journal-article","article-title":"Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials","volume":"65","author":"Davidenko","year":"2018","journal-title":"Acta Biomater."},{"key":"jneaeb32cbib27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10237-024-01911-w","type":"journal-article","article-title":"Biomechanical modelling infers that collagen content within peripheral nerves is a greater indicator of axial Young\u2019s modulus than structure","volume":"24","author":"Doman","year":"2025","journal-title":"Biomech. Model. Mechanobiol."},{"key":"jneaeb32cbib28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104624","type":"journal-article","article-title":"The effect of injurious compression on the elastic, hyper-elastic and visco-elastic properties of porcine peripheral nerves","volume":"121","author":"Fraser","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"jneaeb32cbib29","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-019-0647-0","type":"journal-article","article-title":"Processing of collagen based biomaterials and the resulting materials properties","volume":"18","author":"Meyer","year":"2019","journal-title":"Biomed. Eng. Online"},{"key":"jneaeb32cbib30","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.1016\/j.actbio.2010.07.004","type":"journal-article","article-title":"Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy","volume":"6","author":"Raub","year":"2010","journal-title":"Acta Biomater."},{"key":"jneaeb32cbib31","doi-asserted-by":"publisher","first-page":"5251","DOI":"10.1016\/j.biomaterials.2009.07.007","type":"journal-article","article-title":"Strategies for inducing the formation of bands of B\u00fcngner in peripheral nerve regeneration","volume":"30","author":"Ribeiro-Resende","year":"2009","journal-title":"Biomaterials"},{"key":"jneaeb32cbib32","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fbioe.2020.580654","type":"journal-article","article-title":"Tissue engineered bands of b\u00fcngner for accelerated motor and sensory axonal outgrowth","volume":"20","author":"Panzer","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"jneaeb32cbib33","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/jbm.a.37598","type":"journal-article","article-title":"Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds","volume":"112","author":"Tenchurin","year":"2024","journal-title":"J. Biomed. Mater. Res. A"},{"key":"jneaeb32cbib34","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s13770-017-0075-9","type":"journal-article","article-title":"Electrospun collagen nanofibers and their applications in skin tissue engineering","volume":"14","author":"Law","year":"2017","journal-title":"Tissue Eng. Regen. Med."},{"key":"jneaeb32cbib35","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3390\/polym13050755","type":"journal-article","article-title":"Fabrication and properties of electrospun collagen tubular scaffold crosslinked by physical and chemical treatments","volume":"13","author":"Chen","year":"2021","journal-title":"Polymers"},{"key":"jneaeb32cbib36","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1021\/acs.chemrev.8b00593","type":"journal-article","article-title":"Electrospinning and electrospun nanofibers: methods, materials, and applications","volume":"119","author":"Xue","year":"2019","journal-title":"Chem. Rev."},{"key":"jneaeb32cbib37","doi-asserted-by":"publisher","DOI":"10.1063\/1.2372694","type":"journal-article","article-title":"Drawing suspended polymer micro-\/nanofibers using glass micropipettes","volume":"89","author":"Nain","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"jneaeb32cbib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112525","type":"journal-article","article-title":"Multi-pin contact drawing enables production of anisotropic collagen fiber substrates for alignment of fibroblasts and monocytes","volume":"215","author":"Verma","year":"2022","journal-title":"Colloids Surf. B"},{"key":"jneaeb32cbib39","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202300204","type":"journal-article","article-title":"Multifilament collagen fiber bundles with tendon-like structure and mechanical performance","volume":"44","author":"Yaghoobi","year":"2023","journal-title":"Macromol. Rapid Commun."},{"key":"jneaeb32cbib40","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aad65b","type":"journal-article","article-title":"Directed and enhanced neurite outgrowth following exogenous electrical stimulation on carbon nanotube-hydrogel composites","volume":"15","author":"Imaninezhad","year":"2018","journal-title":"J. Neural Eng."},{"key":"jneaeb32cbib41","doi-asserted-by":"publisher","first-page":"9855","DOI":"10.1038\/s41598-018-27784-5","type":"journal-article","article-title":"Electrical stimulation with a conductive polymer promotes neurite outgrowth and synaptogenesis in primary cortical neurons in 3D","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"jneaeb32cbib42","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1109\/TBME.2015.2492998","type":"journal-article","article-title":"Stimulation frequency alters the dorsal root ganglion neurite growth and directionality In Vitro","volume":"63","author":"Kumar","year":"2016","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"jneaeb32cbib43","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1152\/physrev.00020.2004","type":"journal-article","article-title":"Controlling cell behavior electrically: current views and future potential","volume":"85","author":"McCaig","year":"2005","journal-title":"Physiol. Rev."},{"key":"jneaeb32cbib44","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1523\/JNEUROSCI.02-04-00483.1982","type":"journal-article","article-title":"Orientation of neurite growth by extracellular electric fields","volume":"2","author":"Patel","year":"1982","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s12015-016-9654-8","type":"journal-article","article-title":"The role of direct current electric field-guided stem cell migration in neural regeneration","volume":"12","author":"Yao","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"jneaeb32cbib46","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.semcdb.2008.12.009","type":"journal-article","article-title":"Electrical fields in wound healing\u2014An overriding signal that directs cell migration","volume":"20","author":"Zhao","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"jneaeb32cbib47","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1007\/s10439-014-1001-0","type":"journal-article","article-title":"Electrical and neurotrophin enhancement of neurite outgrowth within a 3D collagen scaffold","volume":"42","author":"Adams","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"jneaeb32cbib48","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.3724\/abbs.2023238","type":"journal-article","article-title":"Alternating current stimulation promotes neurite outgrowth and plasticity in neurons through activation of the PI3K\/AKT signaling pathway","volume":"55","author":"Zhong","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"jneaeb32cbib49","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/4\/046002","type":"journal-article","article-title":"Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation","volume":"11","author":"Koppes","year":"2014","journal-title":"J. Neural Eng."},{"key":"jneaeb32cbib50","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1007\/s10439-014-1058-9","type":"journal-article","article-title":"Short duration electrical stimulation to enhance neurite outgrowth and maturation of adult neural stem progenitor cells","volume":"42","author":"Kobelt","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"jneaeb32cbib51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41420-024-01820-y","type":"journal-article","article-title":"Electrical pulse stimulation parameters modulate N2a neuronal differentiation","volume":"10","author":"Mart\u00edn","year":"2024","journal-title":"Cell Death Discov."},{"key":"jneaeb32cbib52","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1081458","type":"journal-article","article-title":"Electrical stimulation therapy for peripheral nerve injury","volume":"14","author":"Ni","year":"2023","journal-title":"Front. Neurol."},{"key":"jneaeb32cbib53","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/(sici)1097-4695(199710)33:4","type":"journal-article","article-title":"Effects of the neurotrophins nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor (BDNF) on neurite growth from adult sensory neurons in compartmented cultures","volume":"33","author":"Kimpinski","year":"1997","journal-title":"J. Neurobiol."},{"key":"jneaeb32cbib54","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3389\/fncel.2018.00522","type":"journal-article","article-title":"The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met","volume":"12","author":"McGregor","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"jneaeb32cbib55","doi-asserted-by":"publisher","DOI":"10.3791\/51991","type":"journal-article","article-title":"Isolation and culture of dissociated sensory neurons from chick embryos","volume":"24 51991","author":"Powell","year":"2014","journal-title":"J. Vis. Exp."},{"key":"jneaeb32cbib56","first-page":"183","type":"book","article-title":"Micro-structured materials and mechanical cues in 3D collagen gels","author":"Phillips","year":"2010"},{"key":"jneaeb32cbib57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120767","type":"journal-article","article-title":"Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration","volume":"272","author":"Dong","year":"2021","journal-title":"Biomaterials"},{"key":"jneaeb32cbib58","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1016\/j.biomaterials.2008.03.042","type":"journal-article","article-title":"The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps","volume":"29","author":"Tae","year":"2008","journal-title":"Biomaterials"},{"key":"jneaeb32cbib59","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/jbm.b.31308","type":"journal-article","article-title":"Orienting neurite growth in electrospun fibrous neural conduits","volume":"90B","author":"Yao","year":"2009","journal-title":"J. Biomed. Mater. Res. B"},{"key":"jneaeb32cbib60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.actbio.2017.01.023","type":"journal-article","article-title":"Controlling the morphology and outgrowth of nerve and neuroglial cells: the effect of surface topography","volume":"51","author":"Simitzi","year":"2017","journal-title":"Acta Biomater."},{"key":"jneaeb32cbib61","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1529\/biophysj.105.073114","type":"journal-article","article-title":"Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures","volume":"90","author":"Georges","year":"2006","journal-title":"Biophys. J."},{"key":"jneaeb32cbib62","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/dneu.20931","type":"journal-article","article-title":"Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions","volume":"71","author":"Myers","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"jneaeb32cbib63","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fncel.2015.00244","type":"journal-article","article-title":"Mechanochemical regulation of growth cone motility","volume":"9","author":"Kerstein","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"jneaeb32cbib64","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0006-3495(91)82027-6","type":"journal-article","article-title":"Mathematical model for the effects of adhesion and mechanics on cell migration speed","volume":"60","author":"DiMilla","year":"1991","journal-title":"Biophys. J."},{"key":"jneaeb32cbib65","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.93700.2","type":"journal-article","article-title":"Cell adhesion-dependent biphasic axon outgrowth elucidated by femtosecond laser impulse","volume":"13","author":"Yamada","year":"2025","journal-title":"eLife"},{"key":"jneaeb32cbib66","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nmeth.3839","type":"journal-article","article-title":"Practical guide to hydrogels for cell culture","volume":"13","author":"Caliari","year":"2016","journal-title":"Nat. Methods"},{"key":"jneaeb32cbib67","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/4\/046023","type":"journal-article","article-title":"Neurite outgrowth is significantly increased by the simultaneous presentation of Schwann cells and moderate exogenous electric fields","volume":"8","author":"Koppes","year":"2011","journal-title":"J. Neural Eng."},{"key":"jneaeb32cbib68","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/6\/4\/046003","type":"journal-article","article-title":"Applied electric field enhances DRG neurite growth: influence of stimulation media, surface coating and growth supplements","volume":"6","author":"Wood","year":"2009","journal-title":"J. Neural Eng."},{"key":"jneaeb32cbib69","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/cm.20354","type":"journal-article","article-title":"Directional change produced by perpendicularly-oriented microgrooves is microtubule-dependent for fibroblasts and epithelium","volume":"66","author":"Hamilton","year":"2009","journal-title":"Cell Motil."},{"key":"jneaeb32cbib70","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1016\/j.bioactmat.2021.04.019","type":"journal-article","article-title":"Anisotropic scaffolds for peripheral nerve and spinal cord regeneration","volume":"6","author":"Xue","year":"2021","journal-title":"Bioact. Mater."},{"key":"jneaeb32cbib71","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3390\/biology12070954","type":"journal-article","article-title":"Clutching at guidance cues: the integrin\u2013FAK axis steers axon outgrowth","volume":"12","author":"Davis-Lunn","year":"2023","journal-title":"Biology"},{"key":"jneaeb32cbib72","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/polym14050876","type":"journal-article","article-title":"The molecular interaction of collagen with cell receptors for biological function","volume":"14","author":"Elango","year":"2022","journal-title":"Polymers"},{"key":"jneaeb32cbib73","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/humu.21401","type":"journal-article","article-title":"Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes","volume":"32","author":"Parkin","year":"2011","journal-title":"Hum. Mutat."},{"key":"jneaeb32cbib74","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1021\/acs.biomac.5c01404","type":"journal-article","article-title":"Collagen-fibronectin crosstalk in engineered matrices: synergistic assembly orchestrates fibrillar morphogenesis and cell adhesion-migration dynamics","volume":"27","author":"Hou","year":"2025","journal-title":"Biomacromolecules"},{"key":"jneaeb32cbib75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012577","type":"journal-article","article-title":"The structural interactions of molecular and fibrillar collagen type i with fibronectin and its role in the regulation of mesenchymal stem cell morphology and functional activity","volume":"23","author":"Nashchekina","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"jneaeb32cbib76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022422118","type":"journal-article","article-title":"Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation","volume":"118","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"jneaeb32cbib77","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200360","type":"journal-article","article-title":"To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease","volume":"11","author":"Khalilgharibi","year":"2021","journal-title":"Open Biol."},{"key":"jneaeb32cbib78","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200456","type":"journal-article","article-title":"Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila","volume":"149","author":"T\u00f6pfer","year":"2022","journal-title":"Development"},{"key":"jneaeb32cbib79","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1016\/j.actbio.2014.01.032","type":"journal-article","article-title":"Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon","volume":"10","author":"Szczesny","year":"2014","journal-title":"Acta Biomater."},{"key":"jneaeb32cbib80","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jdsr.2019.11.002","type":"journal-article","article-title":"glance on the role of fibronectin in controlling cell response at biomaterial interface","volume":"56","author":"Parisi","year":"2020","journal-title":"Jpn. Dent Sci. Rev."},{"key":"jneaeb32cbib81","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1016\/j.bioactmat.2021.02.021","type":"journal-article","article-title":"Mechanistic insights into the adsorption and bioactivity of fibronectin on surfaces with varying chemistries by a combination of experimental strategies and molecular simulations","volume":"6","author":"Hao","year":"2021","journal-title":"Bioact. Mater."},{"key":"jneaeb32cbib82","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/smll.201401574","type":"journal-article","article-title":"Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities","volume":"11","author":"Romano","year":"2015","journal-title":"Small"},{"key":"jneaeb32cbib83","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.bpj.2015.08.013","type":"journal-article","article-title":"Substrate deformation predicts neuronal growth cone advance","volume":"109","author":"Athamneh","year":"2015","journal-title":"Biophys. J."},{"key":"jneaeb32cbib84","doi-asserted-by":"publisher","first-page":"6813","DOI":"10.1074\/jbc.275.10.6813","type":"journal-article","article-title":"Three-dimensional migration of neurites is mediated by adhesion site density and affinity","volume":"275","author":"Schense","year":"2000","journal-title":"J. Biol. Chem."},{"key":"jneaeb32cbib85","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.neuron.2012.03.005","type":"journal-article","article-title":"Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane","volume":"73","author":"Vitriol","year":"2012","journal-title":"Neuron"},{"key":"jneaeb32cbib86","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1523\/JNEUROSCI.04-12-03051.1984","type":"journal-article","article-title":"Correlation between growth form and movement and their dependence on neuronal age","volume":"4","author":"Argiro","year":"1984","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib87","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/cm.970130407","type":"journal-article","article-title":"Rapid growth cone translocation on laminin is supported by lamellipodial not filopodial structures","volume":"13","author":"Kleitman","year":"1989","journal-title":"Cell Motil."},{"key":"jneaeb32cbib88","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1523\/JNEUROSCI.14-11-07024.1994","type":"journal-article","article-title":"Retinal axon divergence in the optic chiasm: dynamics of growth cone behavior at the midline","volume":"14","author":"Godement","year":"1994","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib89","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1523\/JNEUROSCI.05-09-02345.1985","type":"journal-article","article-title":"Growth cone morphology and trajectory in the lumbosacral region of the chick embryo","volume":"5","author":"Tosney","year":"1985","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib90","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.29.925602","type":"preprint","article-title":"Variation and selection in axon navigation through microtubule-dependent stepwise growth cone advance","author":"Turney","year":"2020"},{"key":"jneaeb32cbib91","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1523\/JNEUROSCI.4209-05.2006","type":"journal-article","article-title":"Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts","volume":"26","author":"Woo","year":"2006","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib92","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1523\/JNEUROSCI.5331-07.2008","type":"journal-article","article-title":"Molecular clutch between the actin flow and n-cadherin adhesions drives growth cone migration","volume":"28","author":"Bard","year":"2008","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib93","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.devcel.2008.05.016","type":"journal-article","article-title":"II activity facilitates microtubule bundling in the neuronal growth cone neck","volume":"15","author":"Burnette","year":"2008","journal-title":"Dev. Cell"},{"key":"jneaeb32cbib94","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/jbm.a.30203","type":"journal-article","article-title":"Adhesive and mechanical properties of hydrogels influence neurite extension","volume":"72A","author":"Gunn","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"key":"jneaeb32cbib95","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/cm.20518","type":"journal-article","article-title":"Micropatterned ECM substrates reveal complementary contribution of low and high affinity ligands to neurite outgrowth","volume":"68","author":"F\u00e9r\u00e9ol","year":"2011","journal-title":"Cytoskeleton"},{"key":"jneaeb32cbib96","doi-asserted-by":"publisher","first-page":"5583","DOI":"10.3390\/ijms22115583","type":"journal-article","article-title":"The CNS\/PNS extracellular matrix provides instructive guidance cues to neural cells and neuroregulatory proteins in neural development and repair","volume":"22","author":"Melrose","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"jneaeb32cbib97","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2026.107374","type":"journal-article","article-title":"The extracellular matrix as a dynamic regulator of brain function and plasticity","volume":"223","author":"Ge","year":"2026","journal-title":"Neurobiol. Dis."},{"key":"jneaeb32cbib98","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214633","type":"journal-article","article-title":"Laminin 1 enhances the angiogenic and neurogenic potential of collagen-based scaffolds for complex wound healing applications","volume":"181","author":"McGrath","year":"2026","journal-title":"Biomater. Adv."},{"key":"jneaeb32cbib99","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/9\/4\/046007","type":"journal-article","article-title":"The impact of laminin on 3D neurite extension in collagen gels","volume":"9","author":"Swindle-Reilly","year":"2012","journal-title":"J. Neural Eng."},{"key":"jneaeb32cbib100","doi-asserted-by":"publisher","first-page":"tkae049","DOI":"10.1093\/burnst\/tkae049","type":"journal-article","article-title":"Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment","volume":"12","author":"Lu","year":"2024","journal-title":"Burns Trauma"},{"key":"jneaeb32cbib101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67046-1","type":"journal-article","article-title":"Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration","volume":"14","author":"Tusnim","year":"2024","journal-title":"Sci. Rep."},{"key":"jneaeb32cbib102","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fncel.2018.00447","type":"journal-article","article-title":"An integrated cytoskeletal model of neurite outgrowth","volume":"12","author":"Miller","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"jneaeb32cbib103","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neulet.2006.10.030","type":"journal-article","article-title":"Embryonic zebrafish neuronal growth is not affected by an applied electric field in vitro","volume":"411","author":"Cormie","year":"2007","journal-title":"Neurosci. Lett."},{"key":"jneaeb32cbib104","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1038\/s41467-020-20179-z","type":"journal-article","article-title":"Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling","volume":"11","author":"De Virgiliis","year":"2020","journal-title":"Nat. Commun."},{"key":"jneaeb32cbib105","doi-asserted-by":"publisher","first-page":"14883","DOI":"10.1073\/pnas.0505164102","type":"journal-article","article-title":"Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"jneaeb32cbib106","doi-asserted-by":"publisher","first-page":"572","DOI":"10.4103\/1673-5374.180740","type":"journal-article","article-title":"Extrinsic and intrinsic mechanisms of axon regeneration: the need for spinal cord injury treatment strategies to address both","volume":"11","author":"Vogelaar","year":"2016","journal-title":"Neural Regen. Res."},{"key":"jneaeb32cbib107","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000519068","type":"journal-article","article-title":"Time in neurogenesis: conservation of the developmental formation of the cerebellar circuitry","volume":"97","author":"Rueda-Ala\u00f1a","year":"2021","journal-title":"Brain Behav. Evol."},{"key":"jneaeb32cbib108","doi-asserted-by":"publisher","first-page":"eaba7667","DOI":"10.1126\/science.aba7667","type":"journal-article","article-title":"Species-specific developmental timing is associated with global differences in protein stability in mouse and human","volume":"369","author":"Rayon","year":"2020","journal-title":"Science"},{"key":"jneaeb32cbib109","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cne.22248","type":"journal-article","article-title":"Patterned assembly and neurogenesis in the chick dorsal root ganglion","volume":"518","author":"George","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"jneaeb32cbib110","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ydbio.2012.03.027","type":"journal-article","article-title":"Defining structural homology between the mammalian and avian hippocampus through conserved gene expression patterns observed in the chick embryo","volume":"366","author":"Gupta","year":"2012","journal-title":"Dev. Biol."},{"key":"jneaeb32cbib111","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp3957","type":"journal-article","article-title":"Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium","volume":"387","author":"Hecker","year":"2025","journal-title":"Science"},{"key":"jneaeb32cbib112","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/(SICI)1096-9861(19960122)364:4","type":"journal-article","article-title":"Expression of neurotrophins and trk receptors in the avian retina","volume":"364","author":"Hallb\u00f6\u00f6k","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"jneaeb32cbib113","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1097\/00001756-199511270-00003","type":"journal-article","article-title":"Neurotrophin receptor expression during development of the chick spinal sensory ganglion","volume":"6","author":"Williams","year":"1995","journal-title":"Neuroreport"},{"key":"jneaeb32cbib114","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2023.1162049","type":"journal-article","article-title":"Single-cell transcriptomic profiling of dorsal root ganglion: an overview","volume":"17","author":"Xie","year":"2023","journal-title":"Front. Neuroanat."},{"key":"jneaeb32cbib115","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/cne.902830105","type":"journal-article","article-title":"Extracellular matrix components of the peripheral pathway of chick trigeminal axons","volume":"283","author":"Moody","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"jneaeb32cbib116","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1523\/JNEUROSCI.13-11-04880.1993","type":"journal-article","article-title":"Expression of \u03b21 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms","volume":"13","author":"Tomaselli","year":"1993","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib117","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0012-1606(83)90356-1","type":"journal-article","article-title":"Ionic behaviors and nerve growth factor dependence in developing chick ganglia. II. Studies with neurons of dorsal root ganglia","volume":"98","author":"Skaper","year":"1983","journal-title":"Dev. Biol."},{"key":"jneaeb32cbib118","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1113\/jphysiol.1977.sp011813","type":"journal-article","article-title":"The action potential of chick dorsal root ganglion neurones maintained in cell culture","volume":"267","author":"Dichter","year":"1977","journal-title":"J. Physiol."},{"key":"jneaeb32cbib119","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1523\/JNEUROSCI.23-05-01781.2003","type":"journal-article","article-title":"Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation","volume":"23","author":"Guan","year":"2003","journal-title":"J. Neurosci."},{"key":"jneaeb32cbib120","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jhsa.2017.02.017","type":"journal-article","article-title":"The role of nerve graft substitutes in motor and mixed motor\/sensory peripheral nerve injuries","volume":"42","author":"Rbia","year":"2017","journal-title":"J. Hand Surg."},{"key":"jneaeb32cbib121","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.3389\/fnins.2019.01442","type":"journal-article","article-title":"Experimental testing of bionic peripheral nerve and muscle interfaces: animal model considerations","volume":"13","author":"Aman","year":"2020","journal-title":"Front. Neurosci."}],"container-title":["Journal of Neural Engineering"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T07:24:11Z","timestamp":1792999451000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/aeb32c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":121,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10,26]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1741-2552\/aeb32c","relation":{},"ISSN":["1741-2560","1741-2552"],"issn-type":[{"value":"1741-2560","type":"print"},{"value":"1741-2552","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"Multimodal regulation of neurite extension by extracellular matrix composition and electrical stimulation on aligned collagen fiber scaffolds","name":"article_title","label":"Article Title"},{"value":"Journal of Neural Engineering","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2026-03-27","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-10-12","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-10-26","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}