{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:08:53Z","timestamp":1788520133060,"version":"build-2803163510"},"reference-count":46,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Presidential Foundation of Nanfang Hospital, China","award":["2014C014"],"award-info":[{"award-number":["2014C014"]}]},{"name":"Guangdong Education Department Foundation","award":["2013CXZDA010"],"award-info":[{"award-number":["2013CXZDA010"]}]},{"name":"Science and Technology Program of Guangdong, China","award":["2016B090913004"],"award-info":[{"award-number":["2016B090913004"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["201508020035"],"award-info":[{"award-number":["201508020035"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31440043"],"award-info":[{"award-number":["31440043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2017,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of a new generation of biomaterials with high osteogenic ability for treatment of osteoporotic fractures is being intensively investigated. The objective of this paper was to investigate new bone formation in an ovariectomized rat (OVX rat) calvarial model of critical size bone defects filled with Sr-containing\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -calcium sulfate hemihydrate (SrCSH) cement compared to an\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -calcium sulfate hemihydrate (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -CSH) cement and empty defect. X-ray diffraction analysis verified the partial substitution of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    for Ca\n                    <jats:sup>2+<\/jats:sup>\n                    did not change the phase composition of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -CSH. Scanning electron microscopy showed that Sr-substituted\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -CSH significantly increased the surface roughness. The effects of Sr substitution on the biological properties of SrCSH cement were evaluated by adhesion, proliferation, alkaline phosphatase (ALP) activity of osteoblast-like cells MC3T3-E1. The results showed that SrCSHs enhanced MC3T3-E1 cell proliferation, differentiation, and ALP activity. Furthermore, SrCSH cement was used to repair critical-sized OVX rat calvarial defects. The\n                    <jats:italic>in vivo<\/jats:italic>\n                    results revealed that SrCSH had good osteogenic capability and stimulated new blood vessel formation in a critical sized OVX calvarial defect within 12 weeks, suggesting that SrCSH cement has more potential for application in bone tissue regeneration.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aa68bc","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T05:14:27Z","timestamp":1496639667000},"page":"035004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Enhanced bone formation by strontium modified calcium sulfate hemihydrate in ovariectomized rat critical-size calvarial defects"],"prefix":"10.1088","volume":"12","author":[{"given":"Shenyu","family":"Yang","sequence":"first","affiliation":[{"name":"Jinan University"},{"name":"Jinan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanbao","family":"Feng","sequence":"additional","affiliation":[{"name":"Jinan University"},{"name":"Jinan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-5718","authenticated-orcid":false,"given":"Mei","family":"Tu","sequence":"additional","affiliation":[{"name":"Jinan University"},{"name":"Jinan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"bmmaa68bcbib1","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1016\/j.biomaterials.2013.02.033","type":"journal-article","article-title":"Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats","volume":"34","author":"Alghamdi","year":"2013","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.metabol.2003.10.022","type":"journal-article","article-title":"Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells","volume":"53","author":"Barbara","year":"2004","journal-title":"Metabolism"},{"key":"bmmaa68bcbib3","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.1016\/j.biomaterials.2014.03.053","type":"journal-article","article-title":"Combined effect of strontium and zoledronate on hydroxyapatite structure and bone cell responses","volume":"35","author":"Boanini","year":"2014","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bone.2007.08.043","type":"journal-article","article-title":"Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro","volume":"42","author":"Bonnelye","year":"2008","journal-title":"Bone"},{"key":"bmmaa68bcbib5","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.1016\/j.biomaterials.2012.03.069","type":"journal-article","article-title":"The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats","volume":"33","author":"Cao","year":"2012","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib6","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1089\/ten.tea.2011.0355","type":"journal-article","article-title":"Human adipose tissue-derived stromal cell therapy prevents bone loss in ovariectomized nude mouse","volume":"18","author":"Cho","year":"2012","journal-title":"Tissue Eng. A"},{"key":"bmmaa68bcbib7","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1016\/j.actbio.2011.07.004","type":"journal-article","article-title":"Systematic strontium substitution in hydroxyapatite coatings on titanium via micro-arc treatment and their osteoblast\/osteoclast responses","volume":"7","author":"Chung","year":"2011","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/8756-3282(96)00080-4","type":"journal-article","article-title":"The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro","volume":"18","author":"Canalis","year":"1996","journal-title":"Bone"},{"key":"bmmaa68bcbib9","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1016\/j.biomaterials.2012.05.061","type":"journal-article","article-title":"The cementogenic differentiation of periodontal ligament cells via the activation of Wnt\/beta-catenin signalling pathway by Li+ ions released from bioactive scaffolds","volume":"33","author":"Han","year":"2012","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib10","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1002\/jbmr.5650070902","type":"journal-article","article-title":"Perspective: how many women have osteoporosis?","volume":"7","author":"Melton","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"bmmaa68bcbib11","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1359\/jbmr.2005.20.5.886","type":"journal-article","article-title":"How many women have osteoporosis?","volume":"20","author":"Melton","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"bmmaa68bcbib12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1056\/NEJMoa022436","type":"journal-article","article-title":"The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis","volume":"350","author":"Meunier","year":"2004","journal-title":"New Engl. J. Med."},{"key":"bmmaa68bcbib13","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s10856-005-4754-z","type":"journal-article","article-title":"Study of the reactivity and in vitro bioactivity of Sr-substituted alpha-TCP cements","volume":"16","author":"Saint-Jean","year":"2005","journal-title":"J. Mater. Sci., Mater. Med."},{"key":"bmmaa68bcbib14","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/j.1600-0501.2009.01755.x","type":"journal-article","article-title":"Maxillary sinus floor elevation using a tissue-engineered bone complex with beta-TCP and BMP-2 gene-modified bMSCs in rabbits","volume":"20","author":"Jiang","year":"2009","journal-title":"Clin. Oral Implants Res."},{"key":"bmmaa68bcbib15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.biomaterials.2009.09.019","type":"journal-article","article-title":"Modulation of the resorption and osteoconductivity of alpha-calcium sulfate by histone deacetylase inhibitors","volume":"31","author":"Jung","year":"2010","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib16","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.1016\/j.biomaterials.2010.07.112","type":"journal-article","article-title":"The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats","volume":"31","author":"Li","year":"2010","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib17","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.biomaterials.2006.11.001","type":"journal-article","article-title":"Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite","volume":"28","author":"Li","year":"2007","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cej.2013.02.037","type":"journal-article","article-title":"Strontium substituted hydroxyapatite porous microspheres: surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release","volume":"222","author":"Lin","year":"2013","journal-title":"Chem. Eng. J."},{"key":"bmmaa68bcbib19","doi-asserted-by":"publisher","first-page":"6773","DOI":"10.1016\/j.biomaterials.2011.05.080","type":"journal-article","article-title":"The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis","volume":"32","author":"Liu","year":"2011","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib20","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.bone.2007.02.003","type":"journal-article","article-title":"Strontium ranelate: new insights into its dual mode of action","volume":"40","author":"Marie","year":"2007","journal-title":"Bone"},{"key":"bmmaa68bcbib21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/jbm.b.30417","type":"journal-article","article-title":"Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: an in vivo study","volume":"77","author":"Ni","year":"2006","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bmmaa68bcbib22","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.biomaterials.2005.08.006","type":"journal-article","article-title":"Effect of strontium ions on the growth of ROS17\/2.8 cells on porous calcium polyphosphate scaffolds","volume":"27","author":"Qiu","year":"2006","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib23","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","type":"journal-article","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"bmmaa68bcbib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1098-3597(00)90001-2","type":"journal-article","article-title":"Epidemiology and pathogenesis of osteoporosis","volume":"2","author":"Raisz","year":"2000","journal-title":"Clin. Cornerstone"},{"key":"bmmaa68bcbib25","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1002\/art.23461","type":"journal-article","article-title":"Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: results of a five-year, randomized, placebo-controlled trial","volume":"58","author":"Reginster","year":"2008","journal-title":"Arthritis Rheumatism"},{"key":"bmmaa68bcbib26","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1210\/jc.2004-1774","type":"journal-article","article-title":"Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study","volume":"90","author":"Reginster","year":"2005","journal-title":"J. Clin. End. Metab."},{"key":"bmmaa68bcbib27","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/ID.0b013e3180587ad8","type":"journal-article","article-title":"Peri-implant bone regeneration with calcium sulfate: a light and transmission electron microscopy case report","volume":"16","author":"Scarano","year":"2007","journal-title":"Implant Dentistry"},{"key":"bmmaa68bcbib28","doi-asserted-by":"publisher","first-page":"9547","DOI":"10.1016\/j.actbio.2013.07.027","type":"journal-article","article-title":"A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro","volume":"9","author":"Schumacher","year":"2013","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1563\/1548-1336(2002)028<0273:BRWCSE>2.3.CO;2","type":"journal-article","article-title":"Bone regeneration with calcium sulfate: evidence for increased angiogenesis in rabbits","volume":"28","author":"Strocchi","year":"2002","journal-title":"J. Oral Implantology"},{"key":"bmmaa68bcbib30","doi-asserted-by":"publisher","first-page":"8589","DOI":"10.1016\/j.biomaterials.2013.07.036","type":"journal-article","article-title":"Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats","volume":"34","author":"Thormann","year":"2013","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib31","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1532-849X.2008.00433.x","type":"journal-article","article-title":"Outcomes of dental implants in osteoporotic patients. A literature review","volume":"18","author":"Tsolaki","year":"2009","journal-title":"J. Prosthodontics"},{"key":"bmmaa68bcbib32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/BLO.0b013e318059b902","type":"journal-article","article-title":"Increased bone formation using calcium sulfate\u2013calcium phosphate composite graft","volume":"459","author":"Urban","year":"2007","journal-title":"Clin. Orthopaedics Relat. Res."},{"key":"bmmaa68bcbib33","doi-asserted-by":"publisher","first-page":"7776","DOI":"10.1016\/j.biomaterials.2010.06.047","type":"journal-article","article-title":"In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite","volume":"31","author":"Verron","year":"2010","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib34","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/jbm.b.31428","type":"journal-article","article-title":"Comparative evaluation of different crystal-structured calcium sulfates as bone-filling materials","volume":"91","author":"Woo","year":"2009","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bmmaa68bcbib35","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/j.actbio.2010.12.018","type":"journal-article","article-title":"Bioactive SrO\u2013SiO2 glass with well-ordered mesopores: characterization, physiochemistry and biological properties","volume":"7","author":"Wu","year":"2011","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib36","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1016\/j.actbio.2012.06.023","type":"journal-article","article-title":"Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic\/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering","volume":"8","author":"Wu","year":"2012","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib37","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.biomaterials.2012.09.066","type":"journal-article","article-title":"Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity","volume":"34","author":"Wu","year":"2013","journal-title":"Biomaterials"},{"key":"bmmaa68bcbib38","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.msec.2011.11.016","type":"journal-article","article-title":"A novel resorbable \u03b1-calcium sulfate hemihydrate\/amorphous calcium phosphate bone substitute for dental implantation surgery","volume":"32","author":"Wu","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"bmmaa68bcbib39","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1016\/j.surfcoat.2006.10.012","type":"journal-article","article-title":"Preparation and cell\u2013materials interactions of plasma sprayed strontium-containing hydroxyapatite coating","volume":"201","author":"Xue","year":"2007","journal-title":"Surf. Coat. Technol."},{"key":"bmmaa68bcbib40","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/stem.646","type":"journal-article","article-title":"Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt\/catenin signaling","volume":"29","author":"Yang","year":"2011","journal-title":"Stem. Cells"},{"key":"bmmaa68bcbib41","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1016\/S1875-5372(15)60046-7","type":"journal-article","article-title":"Doping of strontium into natural bone powder and further cell experiment","volume":"43","author":"Zhao","year":"2014","journal-title":"Rare Met. Mater. Eng."},{"key":"bmmaa68bcbib42","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1089\/ten.2006.12.1753","type":"journal-article","article-title":"Efficacy of bone marrowderived stem cells in strengthening osteoporotic bone in a rabbit model","volume":"12","author":"Wang","year":"2006","journal-title":"Tissue Eng."},{"key":"bmmaa68bcbib43","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.actbio.2010.08.031","type":"journal-article","article-title":"Effects of strontium in modified biomaterials","volume":"7","author":"Zhang","year":"2011","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib44","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.actbio.2014.10.015","type":"journal-article","article-title":"Three-dimensional printed strontium-containing mesoporous bioactive glass scaffolds for repairing rat critical-sized calvarial defects","volume":"12","author":"Zhao","year":"2015","journal-title":"Acta Biomater."},{"key":"bmmaa68bcbib45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.micromeso.2011.03.007","type":"journal-article","article-title":"The effect of zirconium incorporation on the physiochemical and biological properties of mesoporous bioactive glasses scaffolds","volume":"143","author":"Zhu","year":"2011","journal-title":"Microporous Mesoporous Mater."},{"key":"bmmaa68bcbib46","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.1016\/j.actbio.2013.01.021","type":"journal-article","article-title":"Substitutions of strontium in mesoporous calcium silicate and their physicochemical and biological properties","volume":"9","author":"Zhu","year":"2013","journal-title":"Acta Biomater."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:44:04Z","timestamp":1784987044000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aa68bc"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,6,5]]},"published-print":{"date-parts":[[2017,6,23]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/aa68bc","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,5]]},"assertion":[{"value":"Enhanced bone formation by strontium modified calcium sulfate hemihydrate in ovariectomized rat critical-size calvarial defects","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2017 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2016-12-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-03-23","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-06-05","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}