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Mater."],"published-print":{"date-parts":[[2017,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Few studies have been reported that focus on developing implant surface nanofiber (NF) coating to prevent infection and enhance osseointegration by local drug release. In this study, coaxial doxycycline (Doxy)-doped polycaprolactone\/polyvinyl alcohol (PCL\/PVA) NFs were directly deposited on a titanium (Ti) implant surface during electrospinning. The interaction of loaded Doxy with both PVA and PCL NFs was characterized by Raman spectroscopy. The bonding strength of Doxy-doped NF coating on Ti implants was confirmed by a stand single-pass scratch test. The improved implant osseointegration by PCL\/PVA NF coatings\n                    <jats:italic>in vivo<\/jats:italic>\n                    was confirmed by scanning electron microscopy, histomorphometry and micro computed tomography\n                    <jats:italic>(\u03bc<\/jats:italic>\n                    CT) at 2, 4 and 8 weeks after implantation. The bone contact surface (%) changes of the NF coating group (80%) is significantly higher than that of the no NF group (&lt;5%,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Finally, we demonstrated that a Doxy-doped NF coating effectively inhibited bacterial infection and enhanced osseointegration in an infected (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) tibia implantation rat model. Doxy released from NF coating inhibited bacterial growth up to 8 weeks\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The maximal push-in force of the Doxy-NF coating (38 N) is much higher than that of the NF coating group (6.5 N) 8 weeks after implantation (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), which was further confirmed by quantitative histological analysis and\n                    <jats:italic>\u03bc<\/jats:italic>\n                    CT. These findings indicate that coaxial PCL\/PVA NF coating doped with Doxy and\/or other drugs have great potential in enhancing implant osseointegration and preventing infection.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aa6a26","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T08:14:54Z","timestamp":1490861694000},"page":"045008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Doxycycline-loaded coaxial nanofiber coating of titanium implants enhances osseointegration and inhibits\n                    <i>Staphylococcus aureus<\/i>\n                    infection"],"prefix":"10.1088","volume":"12","author":[{"given":"Wei","family":"Song","sequence":"first","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Seta","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bergum","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Providence Hospital and Medical Centers, Southfield, MI,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhubin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kanneganti","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Providence Hospital and Medical Centers, Southfield, MI,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E","family":"Kast","sequence":"additional","affiliation":[{"name":"Wayne State University"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W","family":"Auner","sequence":"additional","affiliation":[{"name":"Wayne State University"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shen","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Markel","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Providence Hospital and Medical Centers, Southfield, MI,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Ren","sequence":"additional","affiliation":[{"name":"Wayne State University"},{"name":"Department of Orthopedics, Providence Hospital and Medical Centers, Southfield, MI,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"bmmaa6a26bib1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1302\/0301-620X.76B6.7983118","type":"journal-article","article-title":"Does early micromotion of femoral stem prostheses matter? 4\u20137 year stereoradiographic follow-up of 84 cemented prostheses","volume":"76B","author":"Karrholm","year":"1994","journal-title":"J. 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