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Mater."],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An acid-free water-born chitosan derivative\/montmorillonite has been successfully synthesized. A natural-based biopolymer, N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride, was synthesized, and its structure confirmed by Fourier transform infrared microscopy and conductometric titration. It was applied to the cationic ion-exchange reaction of montmorillonite. Then, the synthesized materials were used to produce water-born composite scaffolds for tissue engineering applications and formed an ultra-fine bead-free multicomponent nanofibrous scaffold. The scaffold was subjected to\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    investigations. The effects of both acidic and neutral reaction media on the efficiency of the cationic ion-exchange reaction of montmorillonite were investigated. A mechanism has been suggested for the more efficient cationic ion-exchange reaction achieved in the absence of the acid. In\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies, the modified montmorillonite showed synergistic biocompatibility and cell growth with enhanced bioactivity compared to unmodified clay and even chitosan and the chitosan derivative. Scanning electron microscopy showed ultra-fine bead-free nanocomposite nanofibers. Improved biocompatibility, cell attachment, and cell growth were observed for the nanofibrous scaffolds compared to the individual components.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments showed complete restoration of a critical-sized full-thickness wound without infection in 21 d. The technique provides a guideline to achieve chitosan nanofibrous morphology for multifunctional biomedical applications.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aa7608","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T10:15:37Z","timestamp":1496225737000},"page":"045014","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["An acid-free water-born quaternized chitosan\/montmorillonite loaded into an innovative ultra-fine bead-free water-born nanocomposite nanofibrous scaffold;\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    approaches"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-6370","authenticated-orcid":false,"given":"Roya","family":"Dastjerdi","sequence":"first","affiliation":[{"name":"Yazd University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Sharafi","sequence":"additional","affiliation":[{"name":"Yazd University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Kabiri","sequence":"additional","affiliation":[{"name":"Iran Polymer and Petrochemical Institute (IPPI), PO Box 14965-115, Tehran,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Mivehi","sequence":"additional","affiliation":[{"name":"University of Guilan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Samadikuchaksaraei","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering & Regenerative Medicine Iran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"bmmaa7608bib1","doi-asserted-by":"publisher","first-page":"8776","DOI":"10.1039\/c0jm01443e","type":"journal-article","article-title":"Fiber-reinforced scaffolds for tissue engineering and regenerative medicine: use of traditional textile substrates to nanofibrous arrays","volume":"20","author":"McCullen","year":"2010","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2016-07-15","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-05-31","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-07-26","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}