{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:04:29Z","timestamp":1784988269296,"version":"3.55.0"},"reference-count":49,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"tdm","delay-in-days":8,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["#2012\/23525-9"],"award-info":[{"award-number":["#2012\/23525-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to evaluate the\n                    <jats:italic>in vitro<\/jats:italic>\n                    osteogenic and osteoinductive potentials of BioS-2P and its ability to promote\n                    <jats:italic>in vivo<\/jats:italic>\n                    bone repair. To investigate osteogenic potential, UMR-106 osteoblastic cells were cultured on BioS-2P and Bioglass 45S5 discs in osteogenic medium. The osteoinductive potential was evaluated using mesenchymal stem cells (MSCs) cultured on BioS-2P, Bioglass 45S5 and polystyrene in non-osteogenic medium. Rat bone calvarial defects were implanted with BioS-2P scaffolds alone or seeded with MSCs. UMR-106 proliferation was similar for both materials, while alkaline phosphatase (ALP) activity and mineralization were higher for BioS-2P. Bone sialoprotein (BSP), RUNX2 and osteopontin (OPN) gene expression and BSP, OPN, ALP and RUNX2 protein expression were higher on BioS-2P. For MSCs, ALP activity was higher on Bioglass 45S5 than on BioS-2P and was lower on polystyrene. All genes were highly expressed on bioactive glasses compared to polystyrene. BioS-2P scaffolds promoted\n                    <jats:italic>in vivo<\/jats:italic>\n                    bone formation without differences in the morphometric parameters at 4, 8 and 12 weeks. After 8 weeks, the combination of BioS-2P with MSCs did not increase the quantity of new bone compared to the BioS-2P alone. To stimulate osteoblast activity, drive MSC differentiation and promote bone formation, BioS-2P is a good choice as a scaffold for bone tissue engineering.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aa768e","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T05:15:14Z","timestamp":1496380514000},"page":"045018","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Bioactive-glass ceramic with two crystalline phases (BioS-2P) for bone tissue engineering"],"prefix":"10.1088","volume":"12","author":[{"given":"Emanuela","family":"Prado Ferraz","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gileade","family":"Pereira Freitas","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo","family":"Camuri Crovace","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Carlos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Peitl","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Carlos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Dutra Zanotto","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Carlos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Tambasco","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Mateus Beloti","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Luiz Rosa","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"bmmaa768ebib1","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.8493529","type":"journal-article","article-title":"Tissue engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"bmmaa768ebib2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1601-6343.2005.00329.x","type":"journal-article","article-title":"Engineering craniofacial scaffolds","volume":"8","author":"Hollister","year":"2005","journal-title":"Orthod. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-03-13","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-06-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-08-09","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}