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Mater."],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration\n                    <jats:italic>in vivo<\/jats:italic>\n                    . In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aa9f01","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T10:15:16Z","timestamp":1512382516000},"page":"031001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model"],"prefix":"10.1088","volume":"13","author":[{"given":"He","family":"Tang","sequence":"first","affiliation":[{"name":"Army Medical University (Third Military Medical University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Jia","sequence":"additional","affiliation":[{"name":"Army Medical University (Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Army Medical University (Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Army Medical University (Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ma","family":"Ou Zhu","sequence":"additional","affiliation":[{"name":"Army Medical University (Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Ye","sequence":"additional","affiliation":[{"name":"Army Medical University (Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-9053","authenticated-orcid":false,"given":"Jianwu","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190,"},{"name":"Third Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"bmmaa9f01bib1","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1097\/01.ju.0000121261.03616.63","type":"journal-article","article-title":"The distribution of neuronal and inducible nitric oxide synthase in urethral stricture formation","volume":"171","author":"Cavalcanti","year":"2004","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-05-02","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-12-04","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-02-20","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}