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Mater."],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An active area of research in the field of regenerative medicine involves the development of bioactive matrices that can promote cellular interactions and elicit desirable regenerative behavior\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This is particularly important in the context of ischemic stroke where a focal lesion forms forestalling the regrowth of brain tissue. Protein-based molecules have been used as building blocks to create supramolecular structures that emulate the properties of the native healthy extracellular matrix (ECM) within the central nervous system (CNS). In this review, we briefly describe the relevant biological aspect of stroke and the techniques found in molecular biology and biochemical synthesis methodologies used in the design and synthesis of novel biomaterials. Within these biomaterials, researchers are able to incorporate a number of different domains that trigger assembly or promote cell growth and survival and direct transplanted or endogenous stem cell behavior within the 3D scaffolds. Such domains may also yield stimuli-responsive biomaterial scaffolds where the structure of the hydrogel undergoes a change in response to the local environment. These highly modular proteinaceous materials allow incorporation of diverse biofunctional motifs and structural elements comparable to those found in native ECM. We explore CNS relevant biomaterials that promote cell survival and host tissue integration and discuss their applications to stem cell therapy in the treatment of stroke.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aaa4c3","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T04:00:14Z","timestamp":1514952014000},"page":"034103","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["From de novo peptides to native proteins: advancements in biomaterial scaffolds for acute ischemic stroke repair"],"prefix":"10.1088","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-0720","authenticated-orcid":false,"given":"James D","family":"Tang","sequence":"first","affiliation":[{"name":"University of Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J","family":"Lampe","sequence":"additional","affiliation":[{"name":"University of Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"bmmaaa4c3bib1","author":"WHO Department of Information, Evidence and Research","year":"2016","type":"report"},{"key":"bmmaaa4c3bib2","first-page":"582","type":"journal-article","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2197, 2012)","volume":"384","author":"Murray","year":"2014","journal-title":"Lancet"},{"key":"bmmaaa4c3bib3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000441087","type":"journal-article","article-title":"Stroke prevalence, mortality and disability-adjusted life years in children and youth aged 0\u201319 years: data from the global and regional burden of stroke 2013","volume":"45","author":"Krishnamurthi","year":"2015","journal-title":"Neuroepidemiology"},{"key":"bmmaaa4c3bib4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","type":"journal-article","article-title":"Global and regional burden of stroke during 1990\u20132010: findings from the global burden of disease study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"bmmaaa4c3bib5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","type":"journal-article","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"bmmaaa4c3bib6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000096017","type":"journal-article","article-title":"Pathophysiology of acute ischaemic stroke: an analysis of common signalling mechanisms and identification of new molecular targets","volume":"73","author":"Mitsios","year":"2006","journal-title":"Pathobiology"},{"key":"bmmaaa4c3bib7","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1161\/ATVBAHA.112.252619","type":"journal-article","article-title":"Combination therapy with velcade and tissue plasminogen activator is neuroprotective in aged rats after stroke and targets MicroRNA-146a and the toll-like receptor signaling pathway","volume":"32","author":"Zhang","year":"2012","journal-title":"Arteriosclerosis Thrombosis Vascular"},{"key":"bmmaaa4c3bib8","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1016\/j.molimm.2010.05.009","type":"journal-article","article-title":"Complement activation on platelets: implications for vascular inflammation and thrombosis","volume":"47","author":"Peerschke","year":"2010","journal-title":"Mol. 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