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Mater."],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the present study, composite scaffolds of chitosan-graft-poly(methyl methacrylate) (Chi-g-PMMA) and mineral ions-loaded hydroxyapatite (mHA) (obtained by the hydrothermal treatment of hydroxyapatite (HA) in a simulated body fluid (SBF) solution (mHA@Chi-g-PMMA)) were prepared by the blending method. The physical properties, bioactivity, biological properties and their capabilities for sustained drug and protein release were studied. Physicochemical analysis showed a successful incorporation of the mineral ions in the HA particles and a good distribution of the mHA within the Chi-g-PMMA polymer matrix. The compressive strength and the Young\u2019s modulus were 15.760\u00a0\u00b1\u00a00.718 and 658.452\u00a0\u00b1\u00a017.020 MPa, respectively. In bioactivity studies, more apatite formation on the surface were seen after immersion in the SBF solution.\n                    <jats:italic>In vitro<\/jats:italic>\n                    growth experiments using UMR-106 osteoblast-like cells on the mHA@Chi-g-PMMA scaffold case showed that the attachment, viability and proliferation of the cells on the scaffolds had improved after 7 d of immersion. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    release of two compounds (the cancer drug, doxorubicin (DOX)) and bovine serum albumin (BSA)), which had been attached to separate mHA@Chi-g-PMMA scaffolds, were studied to determine their suitability as drug delivery vehicles. It was found that the sustained release of DOX was 73.95% and of BSA was 57.27% after 25 h of incubation. These experimental results demonstrated that the mHA@Chi-g-PMMA composite can be utilized as a scaffold for bone cells ingrowth and also be used for drug delivery during the bone repairing.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ab025f","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T17:46:56Z","timestamp":1548697616000},"page":"025013","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Fabrication of biocomposite scaffolds made with modified hydroxyapatite inclusion of chitosan-grafted-poly(methyl methacrylate) for bone tissue engineering"],"prefix":"10.1088","volume":"14","author":[{"given":"Tanatsaparn","family":"Tithito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panan","family":"Suntornsaratoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narattaphol","family":"Charoenphandhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirawan","family":"Thongbunchoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nateetip","family":"Krishnamra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-597X","authenticated-orcid":false,"given":"Weeraphat","family":"Pon-On","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"bmmab025fbib1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1741-7015-9-66","type":"journal-article","article-title":"Bone regeneration: current concepts and future directions","volume":"9","author":"Dimitriou","year":"2011","journal-title":"BMC Med."},{"key":"bmmab025fbib2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/458253","type":"journal-article","article-title":"Development of composite scaffolds for load-bearing segmental bone defects","volume":"1","author":"Pilia","year":"2013","journal-title":"BioMed Res. 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