{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:38:54Z","timestamp":1790473134786,"version":"4.1.0"},"reference-count":31,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"crossref","award":["grant #1283\/14"],"award-info":[{"award-number":["grant #1283\/14"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005385","name":"Israel Council for Higher Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005385","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We report the osteogenic potential of silver (Ag), gold (Au), or silver\u2013gold doped hydroxyapatite nanoparticles (Ag-Au-HA) in zebrafish (ZF) jawbone regeneration (JBR) model. The hydroxyapatite (HA, Ca\n                    <jats:sub>10<\/jats:sub>\n                    (PO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>6<\/jats:sub>\n                    (OH)\n                    <jats:sub>2<\/jats:sub>\n                    ), Ag-HA, Au-HA, and Ag-Au-HA nanomaterials were synthesized by the co-precipitation procedure. The surface structures of Ag-HA, Au-HA, HA, and Ag-Au-HA were analysed by scanning electron microscopy, transmission-electron microscopy (TEM), x-ray diffraction, Fourier transform infrared (FTIR), UV\u2013vis, energy dispersive x-ray spectroscopy (EDS), elemental mapping, and laser fluorescent spectroscopy. The TEM and EDS analysis confirmed that the Ag and Au are associated with the surface of HA nanoparticle. The chemical structure of HA, Ag-HA, Au-HA, and Ag-Au-HA nanoparticles was validated by FTIR and EDS analysis. We observed that Ag and Au are associated with HA nanoparticles by electrostatic, wander wall, and electrostatic and H-bonding interaction. The effect of Ag-HA, Au-HA, and Ag-Au-HA nanoparticles on bone regeneration was confirmed by ZF JBR model. The significant growth of ZF bone regeneration was observed in Ag-Au-HA nanoparticles as compared with HA, Ag-HA, and Au-HA nanoparticles. These results indicating a therapeutic potential of Ag-Au-HA compositions suggest these nanomaterials would be excellent for bone regeneration and fracture healing.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ab28e4","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T18:45:28Z","timestamp":1560278728000},"page":"055002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Silver and gold doped hydroxyapatite nanocomposites for enhanced bone regeneration"],"prefix":"10.1088","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-1463","authenticated-orcid":false,"given":"Vijay Bhooshan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Khajuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Karasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1243-2957","authenticated-orcid":false,"given":"Aharon","family":"Gedanken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"bmmab28e4bib1","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1021\/acsnano.6b00087","type":"journal-article","article-title":"Designer dual therapy nanolayered implant coatings eradicate biofilms and accelerate bone tissue repair","volume":"10","author":"Min","year":"2016","journal-title":"ACS Nano"},{"key":"bmmab28e4bib2","doi-asserted-by":"publisher","first-page":"7279","DOI":"10.1021\/acsnano.6b02247","type":"journal-article","article-title":"Nanocomposite membranes enhance bone regeneration through restoring physiological electric microenvironment","volume":"10","author":"Zhang","year":"2016","journal-title":"ACS Nano"},{"key":"bmmab28e4bib3","doi-asserted-by":"publisher","first-page":"8346","DOI":"10.1021\/acsnano.6b02841","type":"journal-article","article-title":"A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation","volume":"10","author":"Lewis","year":"2016","journal-title":"ACS Nano"},{"key":"bmmab28e4bib4","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1021\/nn507488s","type":"journal-article","article-title":"Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach","volume":"9","author":"Xavier","year":"2015","journal-title":"ACS Nano"},{"key":"bmmab28e4bib5","doi-asserted-by":"publisher","first-page":"15029","DOI":"10.1038\/boneres.2015.29","type":"journal-article","article-title":"Nanomaterials and bone regeneration","volume":"3","author":"Gong","year":"2015","journal-title":"Bone Res."},{"key":"bmmab28e4bib6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.nano.2016.08.026","type":"journal-article","article-title":"Antibacterial silk fibroin\/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration","volume":"13","author":"Ribeiro","year":"2017","journal-title":"Nanomed. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-05-07","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-06-11","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-07-08","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}