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Mater."],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    At present, seeking an effective dressing for wound regeneration has drawn considerable interest. In this paper, a novel agarose-grafting-hyaluronan (Ag-g-HA) scaffold was synthesized for rapid wound healing. Elemental analysis results showed that the HA grafting rate of Ag-g-HA was \u223c69%. Ag-g-HA remained bioactive to accelerate cell proliferation and stimulate secretion of TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    for macrophagocyte RAW 264.7, and collagen I and collagen III for fibroblast 3T3. An\n                    <jats:italic>i<\/jats:italic>\n                    <jats:italic>n vivo<\/jats:italic>\n                    study demonstrated that Ag-g-HA showed a faster repair cycle and a better skin histological structure for a full-thickness skin defect. The collagen I, collagen III and TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    secreted by mice for Ag-g-HA were similiar to HA. Ag-g-HA showed a similiar biological activity to HA but had a longer degradation time through its improved insolubility. These findings demonstrate that the Ag-g-HA scaffold accelerated wound healing, and could be a promising novel scaffold for tissue engineering and regenerative medicine.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ab7b3e","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T17:30:38Z","timestamp":1582911038000},"page":"045009","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Preparation and biological evaluation of a novel agarose-grafting-hyaluronan scaffold for accelerated wound regeneration"],"prefix":"10.1088","volume":"15","author":[{"given":"Bin","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-3716","authenticated-orcid":false,"given":"Chaoxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"bmmab7b3ebib1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0305-4179(90)90199-7","type":"journal-article","article-title":"Deep partial skin thickness burns: a reproducible animal model to study burn wound healing","volume":"16","author":"Kaufman","year":"1990","journal-title":"Burns"},{"key":"bmmab7b3ebib2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/0002-9610(71)90482-x","type":"journal-article","article-title":"Effect of laser rays on wound healing","volume":"122","author":"Mester","year":"1971","journal-title":"Am. 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